A5094116283- Aortic Disease and Treatment Approaches
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Medical Imaging and Pathology Studies
Nationwide Children's Hospital
2024
Abstract Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to long-term viability prosthetic these procedures. Herein, we describe natural history most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through retrospective clinical study and an ovine model, compare degree between tissue-engineered grafts Results indicate superior durability grafts,...
Our goal was to conduct a hemodynamic analysis of novel animal model Fontan physiology. Poor late-term outcomes in patients are believed arise from Fontan-induced hemodynamics, but the mechanisms remain poorly understood. Recent advances surgical experimentation have resulted development chronic sheep physiology; however, detailed this is lacking.
Introduction: Patients with single ventricle disease and Fontan circulation suffer long-term morbidity due to the lack of a sub-pulmonary ventricle. The concept pulsatile conduit, functioning as ‘neo-ventricle,’ using engineered heart tissue (EHT), may be potential solution. To this end, we developed tissue-engineered vascular conduit EHT that allowed surgical implantation into murine model for in-vivo assessment. Methods: Mouse-scale conduits were fabricated from type I collagen freeform...