A5013856375- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Blood transfusion and management
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Lysosomal Storage Disorders Research
- Pediatric Pain Management Techniques
- Virus-based gene therapy research
- Pain Management and Opioid Use
- Hemoglobinopathies and Related Disorders
- Cardiovascular Issues in Pregnancy
- Streptococcal Infections and Treatments
- Biochemical and Molecular Research
- Neonatal Health and Biochemistry
- Hernia repair and management
- Metabolism and Genetic Disorders
- Coal Properties and Utilization
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Glycogen Storage Diseases and Myoclonus
Nationwide Children's Hospital
2015-2024
The Ohio State University
2012-2022
The Ohio State University Wexner Medical Center
2015-2022
Johns Hopkins Hospital
2005
Johns Hopkins University
2005
New Mexico Institute of Mining and Technology
1987-1994
Applied Research Associates
1987-1994
United States Geological Survey
1994
New Mexico Bureau of Geology and Mineral Resources
1994
Mineral Resources
1987
Background: Remimazolam is a benzodiazepine which, like midazolam, has sedative, anxiolytic, and amnestic properties. Ester metabolism results in half-life of 5 - 10 min, limited context sensitive half-life, rapid recovery when the infusion discontinued. Methods: Following Institutional Review Board (IRB) approval, we performed retrospective chart review patients who received remimazolam cardiac catheterization, magnetic resonance imaging (MRI), electrophysiology suites. The primary...
Objective: Few data exist on successes at reducing pediatric catheter-associated bloodstream infections (CA-BSI). The objective was to eradicate CA-BSI with a multifaceted pediatric-relevant intervention proven effective in adult patients. Design: Prospective cohort of intensive care (PICU) patients historical controls. Setting: Multidisciplinary PICU. Patients/Participants: PICU targeting providers. Interventions: Multifaceted involving preintervention staff surveys, provider educational...
General anesthesia or procedural sedation may be required to ensure immobility, facilitate completion of the procedure, and patient comfort during diagnostic therapeutic procedures in cardiac catheterization suite. Although propofol dexmedetomidine are two more commonly chosen agents, concerns regarding their impact on inotropic, chronotropic dromotropic function limit applicability based underlying comorbid conditions. We present three patients with conditions involving pacemaker (natural...
Remimazolam is a novel benzodiazepine with sedative and amnestic properties similar to midazolam. Ester metabolism results in half-life of 5 - 10 min limited context sensitive half-life. We present preliminary retrospective experience its use as primary agent for procedural sedation brief invasive noninvasive procedures. The study cohort included seven patients, ranging age from 14 51 years. administration bolus dosing two patients combination followed by an infusion the other five patients....
Patients with single ventricle heart defects requires a series of staged open-heart procedures, termed Fontan palliation. However, while lifesaving, these operations are associated significant morbidity and early mortality. The attendant complications thought to arise in response the abnormal hemodynamics induced by palliation, although pathophysiology underlying physicochemical changes cardiovascular other organs remain unknown. Here, we investigated microRNA (miRNA) content serum...
Umbilical hernia repair is a common pediatric surgical procedure. While opioid analgesics are feasible option and have long been mainstay in the pharmacological intervention for pain, effort to improve care limit opioid-related adverse effects has led use of alternative techniques, including regional anesthesia. The current study prospectively compares analgesic efficacy three caudal epidural blockade, peripheral nerve local wound infiltration, double-blinded study.A total 39 patients...
Our goal was to conduct a hemodynamic analysis of novel animal model Fontan physiology. Poor late-term outcomes in patients are believed arise from Fontan-induced hemodynamics, but the mechanisms remain poorly understood. Recent advances surgical experimentation have resulted development chronic sheep physiology; however, detailed this is lacking.
Summary Background Mucopolysaccharidosis type III is a progressive disease with worsening airway, pulmonary, and cardiac involvement that may complicate anesthetic care. Aim To prospectively evaluate the incidence of airway issues complications during magnetic resonance imaging (MRI) lumbar puncture (LP) general anesthesia native for patients mucopolysaccharidosis . Method The study was part natural history study. Anesthesia induced sevoflurane, which discontinued after intravenous access...
Objective: To provide the first account of extracorporeal membrane oxygenation therapy failure secondary to abdominal compartment syndrome. Design: Case report. Setting: Pediatric intensive care unit. Patient: A 4-month-old infant with cyanotic congenital heart disease and Escherichia coli sepsis developed distention venous return on oxygenation. Intervention: Emergency cardiac catheterization atrial septectomy were performed. Main Results: Central pressure 120 mm Hg was measured, confirming...
One of the major advantages for patients undergoing minimally invasive surgery as compared to an open surgical procedure is improved recovery profile and decreased opioid requirements in perioperative period. There are no definitive studies comparing analgesic two different types procedure. This study retrospectively compares severely obese adolescents young adults laparoscopic versus robotic-assisted, gastric sleeve resection.With Institutional Review Board approval, medication...
A combination of helium and oxygen (heliox) can facilitate gas exchange limit peak inspiratory pressures through reduced resistance to flow decreased turbulent flow. The these gases has been used for a variety upper lower airway conditions, including patients who were spontaneously breathing, receiving noninvasive ventilation, as well during mechanical ventilation. To date, there are no reports regarding the use heliox in with bronchiolitis obliterans syndrome following lung transplantation....
Pain following thoracotomy is one of the most severe forms postoperative pain. Post-thoracotomy pain may increase risk post-surgical pulmonary complications, mortality, prolong hospitalization, and utilization healthcare resources. To mitigate these effects, anesthesia providers commonly employ continuous epidural infusions, paravertebral blocks, systemic opioids for management improvement mechanics. We report use a erector spinae plane block (ESPB) via peripheral nerve catheter an...
Introduction: Children born with single ventricle heart disease must undergo Fontan palliation. The lack of chronic preclinical animal models has limited the study significant end-organ complications that reduce quality and duration life. Here, we explore surgical strategies to improve survival in a model Methods: Sheep were divided based on approach: stage (SS) versus staged Fontan. Controls age/sex matched cohort. SS surgery consists Glenn, direct anastomosis SVC main pulmonary artery...
Foreign body ingestion is a common event among pediatric patients, especially in children less than 6 years of age. Although most cases are relatively benign, with the foreign passing spontaneously or requiring brief endoscopic procedure for removal, button battery known to cause significant morbidity potential mortality. aorto-esophageal fistula (AEF) rare complication following ingestion, its clinical manifestations and outcomes poor. Early diagnosis aggressive treatment key preventing...
Abstract Adults, older children, and adolescent patients with a BMI categorized as overweight or obese have decreased survival after HTx. Anthropometric correlates of HTx in infants not been well defined. In retrospective analysis the UNOS registry, age 0‐24 months were classified according to WHO height‐for‐age weight‐for‐age norms, arbitrary ‐for‐age percentiles. Outcomes 1‐year survival, conditional long‐term cause‐specific mortality examined. Infants stunted growth definition had...
Over the years, there has been a growing recognition of potential negative sequelae allogeneic blood products on postoperative outcomes following cardiac surgery. In addition, followers Jehovah's Witness (JW) faith have religious restriction against receiving or components. Advances in perioperative care, cardiopulmonary bypass (CPB), and surgical technique minimized need for products. Specific conservation strategies include maximizing preoperative hematocrit coagulation function as well...