A5036038594- Trace Elements in Health
- Iron Metabolism and Disorders
- Cardiac Arrest and Resuscitation
- Heavy Metal Exposure and Toxicity
- Neurological diseases and metabolism
- Hemoglobinopathies and Related Disorders
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanical Circulatory Support Devices
- Emergency and Acute Care Studies
- Folate and B Vitamins Research
- Innovations in Medical Education
- Liver Disease and Transplantation
- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Acute Ischemic Stroke Management
- Pregnancy and preeclampsia studies
- Trauma and Emergency Care Studies
- Cardiac and Coronary Surgery Techniques
- Simulation-Based Education in Healthcare
- Patient Safety and Medication Errors
- Cardiac, Anesthesia and Surgical Outcomes
Dell Children's Medical Center of Central Texas
2021-2023
The University of Texas at Austin
2021-2023
Yale University
2023
Lurie Children's Hospital
2014-2022
Northwestern University
2013-2022
Leicestershire Partnership NHS Trust
2021
Northwestern Medicine
2020
Boston University
2017
Vanderbilt University
2010-2015
Washington University in St. Louis
1996-2015
Aceruloplasminemia is an autosomal recessive disorder of iron metabolism. Affected individuals evidence accumulation in tissue parenchyma association with absent serum ceruloplasmin. Genetic studies such patients reveal inherited mutations the ceruloplasmin gene. To elucidate role homeostasis, we created animal model aceruloplasminemia by disrupting murine ( Cp ) Although normal at birth, −/− mice demonstrate progressive that one year age all animals have a prominent elevation ferritin and...
Ceruloplasmin is an abundant alpha 2-serum glycoprotein that contains 95% of the copper found in plasma vertebrate species. We report here on identification a genetic defect ceruloplasmin gene patient previously noted to have total absence circulating serum association with late-onset retinal and basal ganglia degeneration. In this T2 (transverse relaxation time)-weighted magnetic resonance imaging brain revealed densities consistent iron deposition, liver biopsy confirmed presence excess...
Mechanisms of brain and retinal iron homeostasis have become subjects increased interest after the discovery elevated levels in brains patients with Alzheimer's disease retinas age-related macular degeneration. To determine whether ferroxidase ceruloplasmin (Cp) its homolog hephaestin (Heph) are important for homeostasis, we studied from mice deficient Cp and/or Heph. In normal mice, Heph localize to Müller glia pigment epithelium, a blood-brain barrier. Mice both Heph, but not each...
To determine whether structured handover tool from operating room to pediatric cardiac intensive care unit following surgery is associated with a reduction in the loss of information transfer and an improvement quality communication exchange. In addition, this decrease postoperative complications patient outcomes first 24 hrs stay.Prospective observational clinical study.Pediatric academic medical center.Pediatric patients over 3-yr period. Evaluation studied for two time periods: verbal...
The authors performed a case-cohort study nested within the Atherosclerosis Risk in Communities (ARIC) Study to determine association between plasma ferritin level and risk of type 2 diabetes mellitus. Persons with incident cases diagnosed over an average follow-up period 7.9 years (n = 599) were compared random sample cohort 690). After adjustment for age, gender, menopausal status, ethnicity, center, smoking, alcohol intake, hazard ratio diabetes, comparing fifth quintile first quintile,...
Iron is an essential element in human metabolism but also a potent generator of oxidative damage with levels that increase age. Several studies suggest iron accumulation may be factor age-related macular degeneration (AMD). In prior studies, both overload and features AMD were identified mice deficient the ferroxidase ceruloplasmin (Cp) its homologue hephaestin (Heph) (double knockout, DKO). this study, location timing accumulation, rate reproducibility retinal degeneration, roles stress...
Iron-induced oxidative stress may exacerbate age-related macular degeneration (AMD). Ceruloplasmin/Hephaestin double-knockout (DKO) mice with age-dependent retinal iron accumulation and some features of AMD were used to test protection by the oral chelator deferiprone (DFP).Cultured pigment epithelial (ARPE-19) cells treated DFP. Transferrin receptor mRNA (Tfrc), an indicator levels, was quantified qPCR. In mice, assessed mass spectrometry, histology electroretinography.DFP at 60 μM...
Accumulation of iron occurs in the CNS several neurodegenerative diseases. Iron is essential for life but also has ability to generate toxic free radicals if not properly handled. homeostasis at cellular level therefore important maintain proper function, and its dysregulation can contribute export, a key mechanism levels cells, via ferroportin, ubiquitously expressed transmembrane protein that partners with ferroxidase. A membrane-bound form ferroxidase ceruloplasmin by astrocytes regulates...
Pediatric acute stroke teams are a new phenomenon. We sought to characterize the final diagnoses of children with brain attacks in emergency department where pediatric protocol was activated and describe time neurological evaluation neuroimaging.Clinical demographic information obtained from quality improvement database medical records for consecutive patients (age, ≤20 years) presenting single institution's between April 2011 October 2014. Stroke activation means that neurology resident...
Ceruloplasmin is an abundant serum glycoprotein containing greater than 95% of the copper found in plasma vertebrate species. Although this protein known to function as essential ferroxidase, role ceruloplasmin transport and metabolism remains unclear. To elucidate metabolism, kinetics absorption, transport, distribution, excretion were examined utilizing<sup>64</sup>Cu wild-type aceruloplasminemic mice. No differences gastrointestinal hepatic uptake, or biliary observed these animals....
Summary Because it can undergo reversible changes in oxidation state, iron is an excellent biocatalyst but also a potentially deleterious metal. Iron‐mediated toxicity has been ascribed to Fe(II), which reacts with oxygen generate free radicals that damage macromolecules and cause cell death. However, we now report Fe(III) exhibits microbicidal activity towards strains of Salmonella enterica , Escherichia coli Klebsiella pneumoniae defective the Fe(III)‐responding PmrA/PmrB signal...