A5034745894- Elasticity and Material Modeling
- Elasticity and Wave Propagation
- Rheology and Fluid Dynamics Studies
- Cellular Mechanics and Interactions
- Aortic aneurysm repair treatments
- Automotive and Human Injury Biomechanics
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Connective tissue disorders research
- Atherosclerosis and Cardiovascular Diseases
- Eicosanoids and Hypertension Pharmacology
- Fatigue and fracture mechanics
- Cardiovascular Disease and Adiposity
- Genetic and phenotypic traits in livestock
- Advanced Numerical Methods in Computational Mathematics
- Composite Material Mechanics
- Aortic Disease and Treatment Approaches
- Metal Forming Simulation Techniques
- Nuclear Structure and Function
- Mitochondrial Function and Pathology
- Mechanical Engineering and Vibrations Research
- Electrospun Nanofibers in Biomedical Applications
- Composite Structure Analysis and Optimization
- Advanced Materials and Mechanics
- Probabilistic and Robust Engineering Design
Universitat Politècnica de València
2022-2025
Bioengineering Center
2023
Yale University
2018-2022
Universidad Politécnica de Madrid
2012-2018
Fundación Hospital Provincial de Castellón
2013
Associated Press
2012
Growth and remodeling of soft tissues is a dynamic process several theoretical frameworks have been developed to analyze the time-dependent, mechanobiological and/or biomechanical responses these changes in external loads. Importantly, general processes can often be conveniently separated into truly non-steady contributions steady-state ones. Depending on characteristic times over which loads are applied, time-dependent models sometimes specialized respective time-independent formulations...
Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To identify immuno-mechanical mechanisms responsible for differential we studied thoracic aortas from 129S6/SvEvTac and C57BL/6 J mice before after continuous 14-day angiotensin II infusion, which elevated blood pressure similarly in both strains. Histological biomechanical assessments of excised vessels were similar at baseline, suggesting a common homeostatic set-point mean wall stress. Histology further...
Thoracic aortic aneurysm (TAA) is a localized dilatation of the aorta that can lead to life-threatening dissection or rupture. In vivo assessments TAA progression are largely limited measurements size and growth rate. There promise, however, computational modelling evolving biomechanics could predict future geometry properties from initiating mechanobiological insults. We present an integrated framework train deep operator network (DeepONet)-based surrogate model identify contributing...
Local microstructural defects and insidious positive feedback lead to tortuous arteries that disrupt blood flow.
To reliably assess the rupture risk of aorta, along with hazardousness cardiovascular diseases and other extreme conditions or effect possible treatments, it is necessary to understand influence damage mechanisms frequency rate mechanical loads. In particular, hypobaric hypoxia, an oxygen deficiency in organism due its low atmospheric partial pressure, reported alter properties blood vessels. this work, we characterized passive response seeking capture hypoxia on their elastic, damage,...
Most soft biological tissues exhibit a remarkable ability to adapt sustained changes in mechanical loads. These macroscale adaptations, resulting from mechanobiological cellular responses, are important determinants of physiological behaviors and thus clinical outcomes. Given the complexity such computational models can significantly increase our understanding how contributions different cell types or matrix constituents, their rates turnover evolving properties, ultimately change geometry...