A5035272806- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Photoacoustic and Ultrasonic Imaging
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Elasticity and Material Modeling
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Optical Imaging and Spectroscopy Techniques
- Muscle Physiology and Disorders
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Infectious Aortic and Vascular Conditions
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Thermography and Photoacoustic Techniques
- Adipose Tissue and Metabolism
- Tendon Structure and Treatment
- Exercise and Physiological Responses
- Renal and Vascular Pathologies
- Peripheral Artery Disease Management
Purdue University West Lafayette
2016-2025
Indiana University School of Medicine
2021-2024
Indiana University – Purdue University Indianapolis
2022-2024
Indiana University
2021-2024
University School
2021-2024
RELX Group (Netherlands)
2023
Center for Cancer Research
2016-2022
Stanford University
2007-2021
ORCID
2020
Weldon City Schools
2015-2017
Short-chain fatty acids (SCFAs) are major products of gut microbial fermentation and profoundly affect host health disease. SCFAs generate IL-10(+) regulatory T cells, which may promote immune tolerance. However, can also induce Th1 Th17 cells upon immunological challenges and, therefore, have the potential to inflammatory responses. Because seemingly paradoxical SCFA activities in regulating we investigated, depth, impact elevated levels on tissue inflammation mice. Orally administered...
An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures.Here, we demonstrate a multispectral photoacoustic tomography system for tumor using fat hemoglobin as contrasts.This provides ~3 mm tissue depth ~125 μm axial resolution.The results agreed with the histological findings.A high sensitivity was accomplished, which opens compelling way to assessment.
Vagus nerve stimulation (VNS) is a promising therapy for many neurologic and psychiatric conditions. However, determining stimulus parameters individual patients major challenge. The traditional method of titrating intensity based on patient perception produces highly variable responses. This study explores using the vagal response to measure dose predict physiological effect. Clinicians are investigating use VNS heart failure management, this work aims correlate cardiac measures with fiber...
Objective— To quantitatively compare aortic curvature and motion with resulting aneurysm location, direction of expansion, pathophysiological features in experimental abdominal aneurysms (AAAs). Methods Results— MRI was performed at 4.7 T the following parameters: (1) 3D acquisition for vessel geometry (2) 2D cardiac-gated to quantify luminal motion. Male 24-week-old mice were imaged before after AAA formation induced by angiotensin II (AngII)–filled osmotic pump implantation or infusion...
Targeting the hypoxic tumor microenvironment has a broad impact in cancer epigenetics and therapeutics. Oxygen encapsulated nanosize carboxymethyl cellulosic nanobubbles were developed for mitigating regions of tumors to weaken hypoxia-driven pathways inhibit growth. We show that 5-methylcytosine (5mC) hypomethylation can be reverted enhance treatment by epigenetic regulation, using oxygen sub-100 nm size range, both, vitro vivo. effective significantly delaying progression improving...
New intravesical treatment approaches for bladder cancer are needed as currently approved treatments show several side effects and high tumor recurrence rate. Our study used MB49 murine urothelial carcinoma model to evaluate oxygen encapsulated cellulosic nanobubbles a novel agent imaging ultrasound guided drug delivery. In this study, we that (ONB) can be propelled (up 40 mm/s) precisely in vivo the by an beam. Nanobubble velocity controlled altering power of Doppler beam, while nanobubble...
Invasion of the brain by non-small cell lung cancer (NSCLC) results in a shift blood-brain barrier (BBB) to insufficiently characterized blood-tumor (BTB). Effective drug delivery through BTB is one greatest therapeutic obstacles treating metastases. Using an experimental model, we defined key changes within and BBB around tumor (BAT) region over time. Brain-seeking NSCLC cells were delivered into circulation athymic-nude mice via intracardiac injection developing metastases evaluated...
We are introducing a wireless and passive strain sensing scheme that utilizes ultrasound imaging of highly stretchable hydrogel embedded with zinc oxide (ZnO) nanoparticles, named "ZnO-gel". The incorporation ZnO nanoparticles into polymer network the improves both its elasticity strength. It also serves as an ideal biocompatible contrast agent allows remote interrogation changes in volume or dimensions response to mechanical strains through simple imaging. A systematic study various ratios...
Abstract The growing need for the implementation of stretchable biosensors in body has driven rapid prototyping schemes through direct ink writing multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable an automated nozzle injection system. However, their application medical practices remains challenged reliable recording due to viscoelastic nature yields mechanical and electrical hysteresis under periodic large strains. Herein, we report...
Abstract Abdominal aortic aneurysm (AAA) formation and expansion is highly complex multifactorial, the improvement of animal models an important step to enhance our understanding AAA pathophysiology. In this study, we explore ability influence growth in a topical elastase plus β-Aminopropionitrile (BAPN) mouse model by varying concentration altering cross-linking capability tissue. To do so, assess both chronic acute effects using volumetric ultrasound. Our results suggest that applied...
Abstract Purpose To develop methods to quantify cyclic strain, motion, and curvature of the murine abdominal aorta in vivo. Materials Methods C57BL/6J apoE −/− mice underwent three‐dimensional (3D) time‐of‐flight MR angiography position cardiac‐gated 2D slices at four locations along where circumferential strain lumen centroid motion were calculated. From 3D data, a centerline through was created geometric 0.1‐mm intervals. Medial elastin content quantified with histology postmortem. The...
Organs such as the heart and brain possess intricate fiber structures that are best characterized with three-dimensional imaging. For instance, diffusion-based, magnetic resonance tractography (MRT) enables studies of connectivity remodeling during development disease macroscopically on millimeter scale. Here we present complementary, high-resolution microscopic optical coherence imaging analysis methods that, when used in conjunction clearing techniques, can characterize architecture intact...
An abdominal aortic aneurysm (AAA) is a potentially fatal cardiovascular disease with multifactorial development and progression. Two preclinical models of the (elastase perfusion angiotensin II infusion in apolipoprotein-E-deficient animals) have been developed to study during its initiation To date, most studies used ex vivo methods examine characteristics such as expanded diameter or analytic look at circulating biomarkers. Herein, we provide evidence from ultrasound temporal changes...
Photoacoustic imaging has emerged as a promising technique to improve preclinical and clinical by providing users with label-free optical contrast of tissue. Here, we present proof-of-concept study for noninvasive in vivo murine lipid using 1210 nm light investigate differences periaortic fat among mice different gender, genotypes, maturation. Acquired signals suggest that adult male apoE-/- have greater accumulation compared adolescent males, females, wild-type mice. These results...
A microrobot system comprising an untethered tumbling magnetic microrobot, a two-degree-of-freedom rotating permanent magnet, and ultrasound imaging has been developed for in vitro vivo biomedical applications. The tumbles end-over-end net forward motion due to applied torque from the magnet. By turning rotational axis of two-dimensional directional control is possible was steered along various trajectories, including circular path P-shaped path. capable moving over unstructured terrain...