A5051546366- Elasticity and Material Modeling
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Connective tissue disorders research
- Pulmonary Hypertension Research and Treatments
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cellular Mechanics and Interactions
- Model Reduction and Neural Networks
- Protease and Inhibitor Mechanisms
- Nitric Oxide and Endothelin Effects
- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Nuclear Structure and Function
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Ultrasound Imaging and Elastography
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Effects of Exercise
- Mechanics and Biomechanics Studies
- Hernia repair and management
- Renin-Angiotensin System Studies
- Cardiovascular and Diving-Related Complications
Centre National de la Recherche Scientifique
2023-2025
Université de Montpellier
2023-2025
Yale University
2020-2024
Laboratoire de Mécanique et Génie Civil
2023
Biologie, ingénierie et imagerie pour l'Ophtalmologie
2017-2019
Université Claude Bernard Lyon 1
2017-2019
Mines Saint-Étienne
2019
Inserm
2019
University of Padua
2016
Aortic dissection progresses mainly via delamination of the medial layer wall. Notwithstanding complexity this process, insight has been gleaned by studying in vitro and silico progression driven quasi-static pressurization intramural space fluid injection, which demonstrates that differential propensity along aorta can be affected spatial distributions structurally significant interlamellar struts connect adjacent elastic lamellae. In particular, diverse histological microstructures may...
Local microstructural defects and insidious positive feedback lead to tortuous arteries that disrupt blood flow.
Marfan syndrome, caused by mutations in the gene for fibrillin-1, leads to thoracic aortic aneurysms (TAAs). Phenotypic modulation of vascular smooth muscle cells (SMCs) and ECM (extracellular matrix) remodeling are characteristic both nonsyndromic aneurysms. The protein FN (fibronectin) is elevated tunica media TAAs amplifies inflammatory signaling endothelial SMCs through its main receptor, integrin α5β1. We investigated role α5-specific signals mice which cytoplasmic domain α5 was...
BACKGROUND: Transmural failure of the aorta is responsible for substantial morbidity and mortality; it occurs when mechanical stress exceeds strength. The aortic root ascending are susceptible to dissection rupture in Marfan syndrome, a connective tissue disorder characterized by progressive reduction elastic fiber integrity. Whereas competent fibers endow with compliance resilience, cross-linked collagen confer stiffness We hypothesized that postnatal reductions matrix cross-linking...
Abstract Hypoxemia impairs cardiopulmonary function. We investigated pulmonary artery remodeling in mice exposed to chronic hypoxia for up five weeks and quantified associated changes cardiac lung function, without or with subsequent normoxic recovery the absence presence of exercise pharmacological intervention. Hypoxia-induced stiffening proximal stemmed primarily from adventitial collagen, which resulted part altered inter-cellular signaling phenotypic mural smooth muscle cells...
Disorders in the wall microstructure underlie all forms of vascular disease, such as aortic aneurysm, rupture which is necessarily triggered at microscopic level. In this context, we developed an original experimental approach, coupling a bulge inflation test to multiphoton confocal microscopy, for visualizing 3D micro-structure porcine, human non-aneurysmal and aneurysmal adventitial collagen under increasing pressurization. The experiment complexity on tissues led deeply address...
Medial deterioration leading to thoracic aortic aneurysms arises from multiple causes, chief among them mutations the gene that encodes fibrillin-1 and leads Marfan syndrome. Fibrillin-1 microfibrils associate with elastin form elastic fibers, which are essential structural, functional, instructional components of normal wall. Compromised fibers adversely impact overall structural integrity alter smooth muscle cell phenotype. Despite significant progress in characterizing clinical,...
Microstructural features and mechanical properties are closely related in all soft biological tissues. Both yet exhibit considerable inter-individual differences affected by factors such as aging disease its progression. Histological analysis, modern situ imaging, biomechanical testing have deepened our understanding of these complex interrelations, two key questions remain: (1) Given the specific microstructure, can one predict macroscopic without testing? (2) Can quantify individual...
In this study, a brief, 2-wk period of hypertension in mice led to progressive aortic remodeling, an increase pulse wave velocity, and evidence renal injury, dysfunction, albuminuria. This end-organ damage was associated with persistent infiltration CD8 + γ/δ T cells. We show that inflammatory response is likely due GAS6/Axl signaling can be ameliorated by blocking pathway. propose the altered microvascular mechanical forces caused increased velocity enhance GAS6 release from endothelium,...
The renin–angiotensin system plays a key role in regulating blood pressure, which has motivated many investigations of associated mouse models hypertensive arterial remodelling. Such studies typically focus on histological and cell biological changes, not wall mechanics. This study explores tissue-level ramifications chronic angiotensin II infusion wild-type (WT) type 1b (AngII) receptor null ( Agtr1b −/− ) mice. Biaxial biomechanical immunohistological changes were quantified compared the...
Ascending thoracic aortic aneurysm (ATAA) ruptures are life threatening phenomena which occur in local weaker regions of the diseased wall. As ATAAs evolving pathologies, their growth represents a significant remodeling and degradation microstructural architecture thus mechanical properties. To address need for deeper study failure, it is required to analyze behavior at sub-millimeter scale by making use accurate geometrical kinematical measurements during deformation. For this purpose, we...
Vascular complications are a major cause of illness and death in patients with type 1 diabetes (T1D). Diabetic vascular basement membranes enriched fibronectin (FN), an extracellular matrix protein that amplifies inflammatory signaling endothelial cells through its main receptor, integrin α5β1. Binding the α5 cytoplasmic domain to phosphodiesterase 4D5 (PDE4D5), which increases catalytic activity inhibits antiinflammatory cAMP signaling, was found mediate these effects. Here, we examined...
Hypoxia adversely affects the pulmonary circulation of mammals, including vasoconstriction leading to elevated arterial pressures. The clinical importance changes in structure and function large, elastic arteries is gaining increased attention, particularly regarding impact multiple chronic cardiopulmonary conditions. We establish a multi-disciplinary workflow understand better transcriptional, microstructural, functional artery response sustained hypoxia how these inter-relate. exposed...