A5044135440- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Bayesian Methods and Mixture Models
- Cardiovascular Health and Disease Prevention
- Retinal Imaging and Analysis
- Machine Learning in Bioinformatics
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Fractal and DNA sequence analysis
- Genomics and Phylogenetic Studies
- AI in cancer detection
- Advanced Neuroimaging Techniques and Applications
- Cutaneous Melanoma Detection and Management
- Digital Imaging for Blood Diseases
- Sensory Analysis and Statistical Methods
- Statistical Methods and Inference
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Spectroscopy and Chemometric Analyses
- Cell Image Analysis Techniques
- Ultrasound and Hyperthermia Applications
- Image Retrieval and Classification Techniques
- Statistical Methods and Bayesian Inference
- Transcranial Magnetic Stimulation Studies
Inserm
2015-2024
Laboratoire d’Imagerie Biomédicale
2015-2024
Sorbonne Université
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Assistance Publique – Hôpitaux de Paris
2023
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2019-2021
Université Paris Cité
2014-2017
Institut National de Recherche en Santé Publique
2005
Université Sorbonne Paris Nord
2003
Institut Jacques Monod
1999
We explored DNA structures of genomes by means a new tool derived from the "chaotic dynamical systems" theory (the so-called chaos game representation [CGR]), which allows depiction frequencies oligonucleotides in form images. Using CGR, we observe that subsequences genome exhibit main characteristics whole genome, attesting to validity genomic signature concept. Base concentrations, stretches (runs complementary bases or purines/pyrimidines), and patches (over- underexpressed words various...
To determine the value of IL-10 measurement in aqueous humor (AH) for screening primary intraocular lymphoma (PIOL).One hundred consecutive diagnostic or therapeutic vitrectomies were performed patients with uveitis. During surgery, 100 microL both AH and pure vitreous was taken. levels determined a standard quantitative sandwich enzyme immunoassay technique. Patients distributed two groups: 51 proven PIOL, 108 uveitis divided into 74 etiology 34 idiopathic Groups compared by ANOVA...
Importance of left atrial (LA) phasic function evaluation is increasingly recognized for its incremental value in terms prognosis and risk stratification. LA deformation the pathway normal aging has been characterized using echocardiographic speckle tracking. However, no data are available regarding age-related variations feature-racking (FT) techniques from standard cine magnetic resonance imaging (MRI). We studied 94 healthy adults (41 ± 14 yr, 47 women), who underwent MRI Doppler...
Mapping high-dimensional data in a low-dimensional space, for example, visualization, is problem of increasingly major concern analysis. This paper presents data-driven scaling (DD-HDS), nonlinear mapping method that follows the line multidimensional (MDS) approach, based on preservation distances between pairs data. It improves performance existing competitors with respect to representation data, two ways. introduces (1) specific weighting taking into account concentration measure...
The aim of this study is to quantify aortic backward flow (BF) using phase-contrast cardiovascular magnetic resonance (PC-CMR) and its associations with age, indexes arterial stiffness, geometry. Although PC-CMR blood studies showed a simultaneous presence BF forward (FF) in the ascending aorta (AA), relationship between flows aging as well stiffness geometry healthy volunteers has never been reported. We studied 96 subjects [47 women, 39 ± 15 yr old (19-79 yr)]. Aortic [arch pulse wave...
—The molecular systematics of vertebrates has been based entirely on alignments primary structures macromolecules; however, higher order features DNA sequences not used in traditional studies also contain valuable phylogenetic information. Recent data sets conflict over the placement flightless birds (ratites - paleognaths), but this clade critically influences interpretation character change birds. To help resolve issue, we applied a new bioinformatics approach to largest set currently...
Brain computation relies on effective interactions between ensembles of neurons. In neuroimaging, measures functional connectivity (FC) aim at statistically quantifying such interactions, often to study normal or pathological cognition. Their capacity reflect a meaningful variety patterns as expected from neural in relation cognitive processes remains debated. The relative weights time-varying local neurophysiological dynamics versus static structural (SC) the generation FC measured...
Arterial pulse wave velocity (PWV) is associated with increased mortality in aging and disease. Several studies have shown the accuracy of applanation tonometry carotid-femoral PWV (Cf-PWV) relevance evaluating central aorta stiffness using 2D cardiovascular magnetic resonance (CMR) to estimate PWV, aortic distensibility-derived through theoretical Bramwell-Hill model (BH-PWV). Our aim was compare various methods (aoPWV) estimation from 4D flow CMR, terms associations age, Cf-PWV, BH-PWV...
Background and objective: Several systems for the diagnosis of melanoma from images naevi obtained under controlled conditions have demonstrated comparable efficiency with dermatologists. However, their robustness to analyze daily routine was sometimes questionable. The purpose this work is investigate what extent automatic may be achieved analysis uncontrolled pigmented skin lesions. Materials methods: Images were acquired during regular practice by two dermatologists using Reflex® 24 × 36...
Abstract Background Molecular phylogenetic methods are based on alignments of nucleic or peptidic sequences. The tremendous increase in molecular data permits analyses very long sequences and many species, but also requires to help manage large datasets. Results Here we explore the signal present by genomic signatures, defined as set frequencies short oligonucleotides DNA Although violating standard assumptions traditional – particular explicit statements homology inherent character matrices...
The "chaos game representation" (CGR) paradigm has been implemented to display the use of short oligonucleotides in genomes form fractal images. These images can be considered as a genomic signature. Using an unsupervised classification approach, it is shown that fragments sequences retain most characteristics species they come from. It thus appears possible perform global comparison by means genome found databases. efficiency this approach evaluated function size and length oligonucleotides.
Background Aging‐related arterial stiffness is associated with substantial changes in global and local pressures. The subsequent early return of reflected pressure waves leads to an elevated left ventricular (LV) afterload ultimately a deleterious concentric LV remodeling. Purpose To compute aortic time‐resolved fields healthy subjects from 4D flow MRI define relevant pressure‐based markers while investigating their relationship age, remodeling, as well tonometric augmentation index (AIx)...
We examined the influence of AGTR1 A1166C genotype on 16-year evolution pulse wave velocity (PWV) in a middle-aged population. In cross-sectional study, we reported that presence 1166C allele was associated with higher aortic stiffness compared 1166AA genotype. The study conducted 259 subjects who underwent 3 health check-ups over 16 years at Centre IPC–Paris: an initial visit 1992–1993, intermediate 1998–1999, and final 2007–2008. Aortic assessed during visits by measuring carotid–femoral...
Purpose We sought to noninvasively estimate aortic impedance indices from MR and tonometric data. Materials Methods velocity‐encoded carotid applanation tonometry pressure data of 70 healthy subjects (19–79 years) were used calculate the following spectrum: (i) characteristic (Zc) reflecting pulsatile component left ventricular (LV) afterload, (ii) frequency minimal magnitude related arterial compliance (F MIN ), (iii) total peripheral resistance (TPR) steady LV load, (iv) oscillatory index...