A5032515184- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Underwater Acoustics Research
- Microbial Inactivation Methods
- Microfluidic and Bio-sensing Technologies
- Gas Dynamics and Kinetic Theory
- Nanoplatforms for cancer theranostics
- Underwater Vehicles and Communication Systems
- Cancer Research and Treatments
- Marine animal studies overview
- Cancer, Hypoxia, and Metabolism
- Phase Equilibria and Thermodynamics
- Silicone and Siloxane Chemistry
- Antibiotic Resistance in Bacteria
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- Rheology and Fluid Dynamics Studies
- Scientific Measurement and Uncertainty Evaluation
- Hemoglobin structure and function
- Electrohydrodynamics and Fluid Dynamics
- Antibiotics Pharmacokinetics and Efficacy
Centre National de la Recherche Scientifique
2013-2021
Laboratoire d’Imagerie Biomédicale
2015-2021
Inserm
2008-2021
Ifremer
2019-2021
Sorbonne Université
2013-2021
Laboratoire des applications Thérapeutiques des Ultrasons
2013-2019
UPMC Health System
2015
Université Claude Bernard Lyon 1
2009-2014
Lyon College
2014
We aim to produce emulsions that can act as contrast agents and drug carriers for cancer imaging therapy. To increase tumor detection decrease side effects, it is desirable take advantage of the enhanced permeability retention effect allows nanoparticles accumulate in tissues. do so, emulsion droplets need be small enough stable over time addition enhancing image carrying a payload. In present study, we have investigated properties potentiality theranostic perfluorocarbon stabilized by...
The combination of liposomal doxorubicin (DXR) and confocal ultrasound (US) was investigated for the enhancement drug delivery in a rat tumour model. liposomes, based on unsaturated phospholipid dierucoylphosphocholine, were designed to be stable during blood circulation order maximize accumulation tissue release content upon US stimulation. A setup developed delivering inertial cavitation tumours well-controlled reproducible manner. In vitro studies confirm from liposomes as function dose,...
Background: Targeted and triggered release of liposomal drug using heat or ultrasound represents a promising treatment modality able to increase the therapeutic-totoxicity ratio encapsulated drugs.
We have developed stable emulsions (≥ 3 months) made of nanodroplets (nD) perfluorocarbon (PFC) dispersed in water to serve as theragnostic agent. nD are stabilized by house fluorinated surfactants, named FTAC, which chemical structure can be modified tune their properties. characterized size distributions (mean diameters from 200 600 nm), density, adiabatic compressibility, interfacial tension. US properties the been investigated such attenuation. Lastly, ultrasonic signals backscattered...
Previous in vitro studies conducted our group have shown the feasibility of monitoring drug release from liposomes by an inertial acoustic cavitation index. We currently report vivo experiments utilizing index combined treatment AT2 Dunning tumor grafted rats with focused ultrasound and liposomal doxorubicin. Sixty-three were allocated into seven groups: control, low level treatment, high free doxorubicin+high doxorubicin, doxorubicin+low treatment. Based on pharmacokinetic studies, it was...
Encapsulating chemotherapeutic agents in liposomes improves targeting and efficacy of treatments against some tumors. The present work aims at evaluating if sonosensitive combined with cavitation for drug delivery enhance reduce toxicity. Two focused beams were stabilizing the cloud an imaging probe used guidance. Each 1MHz transducer had a 5cm diameter focal length. Exposure conditions 10.8kW/cm2 Isppa, 250Hz PRF 1% duty cycle. Phosphatidylcholine-based nongaseous loaded Doxorubicin. To...