A5018531694- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Biomarkers in Disease Mechanisms
- Alkaline Phosphatase Research Studies
- Parathyroid Disorders and Treatments
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Aortic aneurysm repair treatments
- Stress Responses and Cortisol
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Vitamin D Research Studies
- Aortic Thrombus and Embolism
- Bone and Joint Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Coronary Interventions and Diagnostics
- Dermatological and Skeletal Disorders
- Nutritional Studies and Diet
Clinique Pasteur
2019-2024
Centre de recherche en Epidémiologie et Santé des Populations
2024
Inserm
2024
Hôpital Rangueil
2018-2019
Abstract Background Breast cancer (BC) radiotherapy (RT) can induce cardiotoxicity, with adverse events often observed many years after BC RT. Subclinical left ventricular (LV) dysfunction be detected early RT global longitudinal strain (GLS) measurement based on 2D speckle-tracking echocardiography. This 6-month follow-up analysis from the BACCARAT prospective study aimed to investigate association between cardiac radiation doses and subclinical LV GLS reduction. Methods The patient group...
Background: Radiotherapy (RT) for breast cancer (BC) can induce coronary artery disease many years after RT. At an earlier stage, during the first two RT, we aimed to evaluate occurrence of increased calcium (CAC) and its association with cardiac exposure. Methods: This prospective study included 101 BC patients treated RT without chemotherapy. Based on CAC CT scans performed before event ‘CAC progression’ was defined by increase in overall score (CAC RT+ years—CAC > 0). Dosimetry evaluated...
Abstract Background Radiotherapy for breast cancer (BC) and its resulting cardiac exposure are associated with subclinical left ventricular dysfunction characterized by early decrease of global longitudinal strain (LS) measurement based on 2D speckle-tracking echocardiography. Recent software allows multi-layer segmental analysis strain, which may be interest to quantify locate the impact myocardial function potentially increase detection radiation-induced cardiotoxicity. The aim study was...
Among cardiac complications of breast cancer radiotherapy (BC RT), there are very limited data on arrhythmia and conduction disorders, in particular severe cases requiring permanent pacemaker implantation (PPMI). Therefore, this exploratory study aimed to evaluate the risk PPMI for BC patients treated with RT, compared general population not RT. The was performed a 1/97 representative sample French health care database (EGB database). Adult women first or without RT between 2008 2016 were...
Background-Radiotherapy (RT) for breast cancer (BC) can lead to an increased risk of coronary artery disease several years after RT. The aim this study was evaluate the development overall, non-calcified and calcified atherosclerotic plaques over 2 BC RT associations with cardiac exposure. Methods-The included 101 left- or right-sided patients treated without chemotherapy. A CT angiography performed before Plaque thorough entire network defined as number plaques. Cardiac exposure quantified...
<title>Abstract</title> <bold>Background: </bold>Radiation therapy (RT) for breast cancer (BC) can result in subtle cardiac dysfunction that occur early after treatment. In 2022, the European Society of Cardiology (ESC) published first guidelines cardio-oncology with a harmonized definition therapy-related (CTRCD). The aim this study was to evaluate CTRCD occurrence over 24 months follow-up RT BC patients and analyze association radiation exposure. <bold>Methods: </bold>The prospective...
Radiation therapy (RT) for breast cancer (BC) can result in subtle cardiac dysfunction that occur early after treatment. In 2022, the European Society of Cardiology (ESC) published first guidelines cardio-oncology with a harmonized definition therapy-related (CTRCD). The aim this study was to evaluate CTRCD occurrence over 24 months follow-up RT BC patients and analyze association radiation exposure. prospective monocentric BACCARAT included treated without chemotherapy, aged 40–75 years,...
<title>Abstract</title> <bold>Background</bold> Post-radiotherapy atrial fibrillation (AF) in breast cancer (BC) patients is a relatively new and understudied topic. AF can increase the risk of stroke other serious cardiovascular complications, compromising patients' quality life survival. Detection AF, both asymptomatic symptomatic forms, therefore essential for optimal management. The objective WATCH study to assess incidence (symptomatic or asymptomatic) occurring throughout 5-years...
<sec> <title>BACKGROUND</title> Post-radiotherapy atrial fibrillation (AF) in breast cancer (BC) patients is a relatively new and understudied topic. AF can increase the risk of stroke other serious cardiovascular complications, compromising patients' quality life survival. Detection AF, both asymptomatic symptomatic forms, therefore essential for optimal management. </sec> <title>OBJECTIVE</title> The aim WATCH study to assess incidence (symptomatic or asymptomatic) occurring throughout...
Abstract The aim of this study was to determine whether CS, measured on the preoperative contrast enhanced multislice computed tomography (MSCT), is associated with Device Success (DS), Major Adverse Cardiac Events (MACE) and paravalvular leaks (PVL) after TAVR. Methods We included 352 consecutive patients who underwent TAVR a standardized MSCT. Valvular calcifications detection defined by adding +100 Hounsfield Unit (HU) mean HU determined Region Of Interest placed in ascending aorta. CS...