A5086144947- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Microbial Inactivation Methods
- Electrostatic Discharge in Electronics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Cancer Treatment and Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Function and Risk Factors
- Neurological Complications and Syndromes
- Lanthanide and Transition Metal Complexes
- Laser-induced spectroscopy and plasma
- Plasma Applications and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Pharmacological Effects and Toxicity Studies
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Toxin Mechanisms and Immunotoxins
- Heart Rate Variability and Autonomic Control
Witten/Herdecke University
2020-2025
Alfried Krupp Hospital
2020-2025
RWTH Aachen University
2009
Abstract Aims Pulsed field ablation (PFA) is a novel atrial fibrillation (AF) modality that has demonstrated preferential tissue ablation, including no oesophageal damage, in first-in-human clinical trials. In the MANIFEST-PF survey, we investigated ‘real world’ performance of only approved PFA catheter, acute effectiveness and safety—in particular, rare effects other unforeseen PFA-related complications. Methods results This retrospective survey included all 24 centres using pentaspline...
Pulsed field ablation is a novel nonthermal cardiac modality using ultra-rapid electrical pulses to cause cell death by mechanism of irreversible electroporation. Unlike the traditional energy sources, pulsed has demonstrated significant preferentiality myocardial tissue ablation, and thus avoids certain thermally mediated complications. However, its safety effectiveness remain unknown in usual clinical care.MANIFEST-PF (Multi-National Survey on Methods, Efficacy, Safety Post-Approval...
Pulsed field ablation (PFA) is a new, non-thermal modality for pulmonary vein (PV) isolation in patients with atrial fibrillation (AF). The multi-centre EUropean Real World Outcomes Field AblatiOn Patients Symptomatic AtRIAl Fibrillation (EU-PORIA) registry sought to determine the safety, efficacy, and learning curve characteristics pentaspline, multi-electrode PFA catheter.All-comer AF from seven high-volume centres were consecutively enrolled. Procedural follow-up data collected. Learning...
Abstract Aims Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. Methods results This international multicentre registry investigates the characteristics oesophageal fistulae after treatment by A total 553 729 ablation procedures (radiofrequency: 62.9%, cryoballoon: 36.2%, other modalities: 0.9%) were performed, at 214 centres in 35 countries. In 78 138 patients [0.025%,...
Real-life data on efficacy and safety of pulsed-field ablation (PFA) using the pentaspline multi-electrode catheter in symptomatic atrial fibrillation (AF) patients is still scarce. This study aims to assess PFA with persistent AF. Data from early commercial use across seven European centers were collected a registry. To confirm extra pulmonary vein (PV) ablation, categorized into two groups: those undergoing isolation (PVI) alone receiving additional ablation. Procedural follow-up...
To evaluate deformation parameters of an endocardial, mid-myocardial, and epicardial myocardial layer in different transmurality infarction assess whether layer-specific analysis allows definition infarct transmurality. Fifty-six patients (mean age 55 ± 9 years, 38 men) with chronic ischaemic left ventricular (LV) dysfunction underwent two-dimensional echocardiography contrast-enhanced magnetic resonance imaging (ceMRI). The extent was determined as relative amount hyperenhancement by ceMRI...
Abstract Aims Catheter ablation for atrial fibrillation (AF) using thermal energy can cause collateral damage. Pulsed field (PFA) is a novel non-thermal source. Few small clinical studies have been published. We report on the first ‘real-world’ experience with pulmonary vein isolation (PVI) PFA paroxysmal AF (PAF). Methods and results Pre- post-ablation, phrenic nerve function was assessed. After high-density left (LA) bipolar voltage mapping, all PVs were individually isolated 13 Fr...
Abstract Aims Pulsed field ablation (PFA) is a novel, non-thermal, cardiac tissue-selective modality. To date, radiofrequency (RF)-guided high-power short-duration (HPSD) represents the gold standard besides cryo-ablation for pulmonary vein isolation (PVI). This single-centre, retrospective study investigated efficacy of PFA-PVI vs. HPSD-RF PVI in terms single-procedure arrhythmia-free outcome and safety real-world setting. Methods results Consecutive, paroxysmal atrial fibrillation (AF)...
Thermal left atrial ablation can cause bronchial damage. Pulsed field (PFA) is a novel, nonthermal modality for paroxysmal fibrillation. We report on effects after pulmonary vein isolation using PFA fibrillation.A computed tomography scan showing the respiratory tract adjacent to was obtained. Oral anticoagulation interrupted procedure day. Peri-procedurally, patients received heparin with an activated clotting time goal of >350 seconds. All veins were individually isolated 13F steerable...
Importance Previous studies evaluating the association of patient sex with clinical outcomes using conventional thermal ablative modalities for atrial fibrillation (AF) such as radiofrequency or cryoablation are controversial due to mixed results. Pulsed field ablation (PFA) is a novel AF energy modality that has demonstrated preferential myocardial tissue unique safety profile. Objective To compare differences in patients undergoing PFA Multinational Survey on Methods, Efficacy, and Safety...
Abstract Introduction Electroporation ablation creates deep and wide myocardial lesions. No data are available on time course characteristics of acute lesion formation. Methods For the phase development, seven pigs were investigated. Single 200 J applications delivered at four different epicardial right ventricular sites using a linear suction device, yielding total 28 Timing was designed to yield lesions points: 0, 10, 20, 30, 40, 50, 60 min, with per point. After killing, histologically...
Background: Injectable cardiac monitors (ICMs) are leadless subcutaneous devices for long-term monitoring of arrhythmias. The BIOTRONIK BIOMONITOR III is a novel ICM with miniaturized profile, long sensing vector, and simplified implantation technique. Methods: R-wave amplitude was recorded immediately after implantation, the day 3 months. Follow-up scheduled months or an event. All data from were retrieved. anatomical position determined post-implantation A patient questionnaire conducted...
BACKGROUND: Recent studies have demonstrated the benefit of early ablation in preventing progression atrial fibrillation (AF). Clinical practice has reflected this shift AF management and no longer requires patients to fail antiarrhythmic drugs (AADs) before receiving ablation. However, there is limited evidence on outcomes with pulsed field (PFA) as a first-line therapy. Examination real-world data may shed light clinical practices effectiveness PFA without prior history AAD usage. METHODS:...
There is clinical and experimental evidence that treatment with immunosuppressive antiproliferative drugs such as the calcineurin inhibitor cyclosporine A (CsA) associated mental health problems neuropsychological disturbances in patients. However, it remains unclear whether to what extent cognitive functions memory attention processes are affected by pharmacological treatment. This partly because of fact difficult refer observed patients drug itself, drug-induced immune suppression, or...