A5105462680- Infection Control and Ventilation
- Antibiotic Resistance in Bacteria
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 detection and testing
- Antibiotic Use and Resistance
- Escherichia coli research studies
- Bacterial Identification and Susceptibility Testing
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Urinary Tract Infections Management
- Neonatal and Maternal Infections
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- Spectroscopy Techniques in Biomedical and Chemical Research
- Atherosclerosis and Cardiovascular Diseases
- Enterobacteriaceae and Cronobacter Research
- Infectious Diseases and Tuberculosis
- Cardiovascular Issues in Pregnancy
- Forensic Entomology and Diptera Studies
- Cutaneous Melanoma Detection and Management
- COVID-19 and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Bacterial biofilms and quorum sensing
Milton Keynes Hospital
2025
Sint Franciscus Gasthuis
2009-2023
Franciscus Vlietland
2020-2022
Erasmus MC - Sophia Children’s Hospital
1998
University of Gothenburg
1993
Lund University
1993
<i>Background:</i> Infections are a common and serious threat to patients with acute ischemic stroke. The aim of this study was assess the effect infection on mortality functional outcome at discharge 1 year. <i>Methods:</i> From consecutive cohort in 11 centers, Netherlands Stroke Survey, we selected 521 stroke admitted hospital within 48 h onset. Stroke-associated defined as occurring 7 days after admission. Poor (modified Rankin score >2) recorded...
Progressive macular hypomelanosis is a common hypopigmentation mainly on the central parts of trunk, predominantly in young adults, especially women. It often mistaken for pityriasis versicolor and alba. occurs all races has been described many world. We discovered follicular red fluorescence restricted to lesional skin. suspected relation with porphyrin-producing bacteria residing sebum pilosebaceous duct, we therefore performed study 8 patients. Observation In biopsy specimens taken from...
Background/Objectives: Infective Endocarditis (IE) presents both a challenging diagnostic and treatment task. Methods: The incidence of IE has grown with the advancement in technologies offered to patients, including intra-cardiac electrical device insertion variety transcutaneous structural interventions. Results: Guidelines recommend involvement multi-disciplinary approach prompt diagnosis decisions regarding treatment. Conclusions: We present management conundrums four complex cases...
Abstract Carbapenemase-producing Klebsiella pneumoniae emerged as a nosocomial pathogen causing morbidity and mortality in patients. For infection prevention it is important to track the spread of K. its plasmids between Therefore, major aim was recapitulate contents diversity genetically related strains harboring beta-lactamase gene bla KPC-2 or KPC-3 determine their dissemination Netherlands former Dutch Caribbean islands from 2014 2019. Next-generation sequencing combined with long-read...
Abstract Verona Integron-encoded Metallo-beta-lactamase (VIM) is the most frequently-encountered carbapenemase in healthcare-related pathogen Pseudomonas aeruginosa . In Netherlands, a low-endemic country for antibiotic-resistant bacteria, no national surveillance data on prevalence of carbapenemase-producing P. (CPPA) was available. Therefore, 2016, pilot study initiated to investigate occurrence, molecular epidemiology, genetic characterization, and resistomes CPPA among isolates submitted...
ABSTRACT We tested a phenyl mannitol broth containing ceftizoxime and aztreonam (PHMB + ) for detection of methicillin-resistant Staphylococcus aureus (MRSA) with reference MRSA strains and, subsequently, clinical samples ( n = 1,098). All induced color change in PHMB after 24 to 72 h incubation. In setting, 40 were detected , compared only 23 routine method. Thus, this selective significantly P < 0.001) improved the rate detection.
ABSTRACT From 1 January 1995 until 1996, we studied the molecular epidemiology of blood isolates coagulase-negative staphylococci (CoNS) in Neonatal Intensive Care Units (NICUs) Sophia Children’s Hospital (SCH; Rotterdam, The Netherlands) and Wilhelmina (WCH; Utrecht, Netherlands). main goal present study was to detect putatively endemic clones CoNS persisting these NICUs. Pulsed-field gel electrophoresis used possible presence clinical significance. In addition, data patients SCH were...
The performances of the BDProbeTec ET (Becton Dickinson) and COBAS AMPLICOR MTB (Roche) were retrospectively evaluated for detecting Mycobacterium tuberculosis complex in various respiratory specimens. BACTEC MGIT liquid culture system was used as a reference method. A total 824 specimens, comprised sputa, bronchoalveolar lavage fluid, bronchial tracheal aspirates from 580 patients, evaluated. Out clinical 109 specimens 43 patients positive M. tuberculosis. Of these 67 smear positive, 85 by...
Lipoproteins can induce complement activation resulting in opsonization and binding of these complexes to receptors. We investigated the opsonized native LDL acetylated (acLDL) receptor 1 (CR1). Binding factors C3b, IgM, C1q, mannose-binding lectin (MBL), properdin acLDL were by ELISA. Subsequent CR1 on CR1-transfected Chinese Hamster Ovarian cells (CHO-CR1) was tested flow cytometry. Both induced with subsequent C3b upon incubation normal human serum. Opsonized bound CR1. CHO-CR1 reduced...
Abstract Airborne transmission is an important route for the spread of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Epidemiological data indicate that certain SARS‐CoV‐2 variants, like omicron variant, are associated with higher transmissibility. We compared virus detection in air samples between hospitalized patients infected different variants or influenza virus. The study was performed during three separate time periods which subsequently alpha, delta, and were...
Direct health effects of antibiotic resistance are difficult to assess. We quantified the risk recurrent bacteremia associated with resistance.We extracted antimicrobial susceptibility testing data on blood isolates from Dutch surveillance system for between 2008 and 2017. First first (4-30 days) episodes were categorized as susceptible, single nonsusceptible, or co-nonsusceptible third-generation cephalosporins without carbapenems (Enterobacteriaceae), ceftazidime (Pseudomonas species),...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Enterobacter species were studied longitudinally in a children's hospital. In total, 287 isolates obtained from 171 children 15 different wards (from March 1995 through April 1997). Strains typed by random amplified polymorphic DNA and pulsed-field gel electrophoresis, which concordant outcome. 97 types 199 colonization events identified. A predominant clone was isolated 111 times 62 children; another 19 10 patients. These clones caused 36% of all colonizations. 34% the children, found 2-4...
We studied nosocomial infections due to Mycobacterium bovis bacille Calmette-Guérin (BCG) Onco-TICE bacteria, transmitted by contamination of medication prepared in BCG Onco-TICE-contaminated hoods the pharmacy, 5 immunocompromised patients at 3 hospitals. The strains cultured from had same DNA profile as strain used for bladder instillation. To prevent these infections, a change open closed preparation was made; strictly separated time instillation and chemotherapy enforced, biological...