A5050837435- COVID-19 epidemiological studies
- Data-Driven Disease Surveillance
- Synthesis and Reactions of Organic Compounds
- COVID-19 Digital Contact Tracing
- HIV, Drug Use, Sexual Risk
- Synthesis of Organic Compounds
- Synthesis and Biological Evaluation
- Viral Infections and Outbreaks Research
- Synthesis and biological activity
- Cervical Cancer and HPV Research
- Synthesis and Characterization of Heterocyclic Compounds
- Global Cancer Incidence and Screening
- Fungal Plant Pathogen Control
- Hepatitis C virus research
- Synthesis of heterocyclic compounds
- Influenza Virus Research Studies
- Hepatitis B Virus Studies
- Disaster Response and Management
- HIV/AIDS Research and Interventions
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical Reaction Mechanisms
- Focus Groups and Qualitative Methods
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Immune responses and vaccinations
- Privacy, Security, and Data Protection
National Institute for Public Health and the Environment
2014-2025
Eindhoven Cancer Registry
2022-2024
University of Regensburg
2024
University Medical Center Utrecht
2013-2015
Utrecht University
2015
Heidelberg University
2015
University Hospital Heidelberg
2015
Health Action International
2015
Karolinska Institutet
2015
Roche (Israel)
2012
Abstract Objective In the course of EU funded Pandemic Preparedness and Response (PANDEM-2) project, a functional exercise (FX) was conducted to train coordinated response large-scale pandemic event in Europe by using new IT solutions developed project. This report provides an overview steps involved planning, conducting, evaluating FX. Methods The FX design based on European Centre for Disease Prevention Control (ECDC) simulation cycle public health settings carried out over 2 days German...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlant Metabolites. Structure and In Vitro Antiviral Activity of Quinovic Acid Glycosides from Uncaria tomentosa Guettarda platyipodaR. Aquino, F. de Simone, C. Pizza, Conti, M. L. SteinCite this: J. Nat. Prod. 1989, 52, 4, 679–685Publication Date (Print):July 1, 1989Publication History Published online1 July 2004Published inissue 1 1989https://pubs.acs.org/doi/10.1021/np50064a002https://doi.org/10.1021/np50064a002research-articleACS...
Background Information on social interactions is needed to understand the spread of airborne infections through a population. Previous studies mostly collected egocentric information independent respondents with self-reported about contacts. Respondent-driven sampling (RDS) technique allowing recruit contacts from their network. We explored feasibility webRDS for studying contact patterns relevant respiratory pathogens. Materials and Methods developed system facilitating tracking recruitment...
Understanding infection dynamics of respiratory diseases requires the identification and quantification behavioural, social environmental factors that permit transmission these infections between humans. Little empirical information is available about contact patterns within real-world networks, let alone on differences in networks populations differ considerably a socio-cultural level. Here we compared network data were collected Netherlands Thailand using similar online respondent-driven...
Abstract SARS-CoV-2 is a novel coronavirus that has rapidly spread across the globe. In Netherlands, first case of been notified on 27 th February. Here, we describe three weeks outbreak in which started with several different introductory events from Italy, Austria, Germany and France followed by local amplification in, later also, outside South Netherlands. The timely generation whole genome sequences combined epidemiological investigations facilitated early decision making an attempt to...
OBJECTIVES Whether the lower Dutch cervical cancer (CC) screening participation of Turkish- and Moroccan-Dutch women is based on informed decision-making unknown. Our aim was to explore how why decide participate or not in current CC programme as well learn their perceptions self-sampling.DESIGN Six focus group discussions were conducted between March April 2019 with Turkish (n = 24) Moroccan 20) Netherlands, aged 30–60 years. Questions an extended version Health Belief Model. Discussions...
Abstract In pandemic preparedness and response, a Functional Exercise (FX) is used to simulate situation as close real‐life event possible without the deployment of resources. Participants are drawn from public health emergency operations centres, work through scenario script test responses novel pathogen outbreak. This paper summarises role system dynamics modelling in design implementation functional exercise, which involved Dutch German national institutes March 2023. The findings confirm...
Health care planning for pandemic influenza is a challenging task which requires predictive models by the impact of different response strategies can be evaluated. However, current preparedness plans and simulations exercises, as well freely available simulation previously made policy makers, do not explicitly address availability health resources or determine shortages on public health. Nevertheless, feasibility systems to implement measures interventions described in trained exercises...
Background Southeast Asia has been the focus of considerable investment in pandemic influenza preparedness. Given wide variation socio-economic conditions, health system capacity across region is likely to impact varying degrees on mitigation operations. We aimed estimate and compare resource gaps, potential mortalities associated with those for responding within between six territories Asia. Methods Findings collected data from Cambodia, Indonesia (Jakarta Bali), Lao PDR, Taiwan, Thailand...
Background Web-based respondent-driven sampling is a novel method for the recruitment of participants generating population estimates, studying social network characteristics, and delivering health interventions. However, application, barriers facilitators, performance web-based have not yet been systematically investigated. Objective Our objectives were to provide an overview published research using investigate factors related sampling. Methods We conducted scoping review on studies...
The antiviral activity of the phenanthrene derivatives 1-6, spyrostane triglycosides dioscin (7) and gracillin (8), furostanol tetraglycosides methylprotodioscin (9), its (25S) epimer methylprotoneodioscin (10), methylprotogracillin 11, have been tested towards two RNA viruses: vesicular stomatitis virus human rhinovirus type 1B. All these products were extracted from rizomes Tamus communis L; compound 11 was isolated also Asparagus cochinchinesis, together with pseudoprotodioscin (12), a 20...
SUMMARY We used a mathematical model to describe regional outbreak and extrapolate the underlying health-service resource needs. This was designed (i) estimate gaps quantities of resources needed, (ii) show effect gaps, (iii) highlight which particular should be improved. ran model, parameterized with data from 2009 H1N1v pandemic, for two provinces in Thailand. The predicted number preventable deaths due shortcomings actual needs are presented Thailand as whole. highlights potentially huge...
In the Netherlands, since 1996, a national cervical cancer (CC) screening program has been implemented for women aged 30 to 60 years. Regional organizations send an invitation letter and information brochure in Dutch home addresses of targeted every 5 Although this is free charge, Turkish- Moroccan-Dutch women, especially, show low participation limited informed decision-making (IDM). As indicated their need on practical, emotional, cultural, religious aspects CC screening, we developed...
The effects of some halogen-substituted flavanoids (dichloroflavan, halogenated isoflavans, and isoflavenes) on poliovirus type 2 infection was examined. Only two isoflavenes exhibited a significant inhibitory activity the virus-induced cytopathic effect plaque formation. In single cycle viral replication, both compounds reduced yield by approximately 90%. presence from beginning or during adsorption period only prevented shutoff host translation RNA protein synthesis, suggesting that drugs...
Substituted homo-isoflavonoids were synthesized in order to study their vitro anti-picornavirus activity. The maximum non-toxic concentration of the compounds for susceptible cells (HeLa) was determined, and ability non-cytotoxic concentrations interfere with plaque formation by human rhinovirus (HRV) 1B 14 poliovirus (PV) 2 examined. All tested weakly effective against PV-2, while they exhibited a variable degree activity HRV-1B -14 infection. Serotype much more sensitive than action...
Transmission of respiratory pathogens in a population depends on the contact network patterns individuals. To accurately understand and explain epidemic behaviour information networks is required, but only limited empirical data available. Online respondent-driven detection can provide relevant epidemiological numbers persons dynamics contacts between pairs We aimed to analyse with respect sociodemographic geographical characteristics, vaccine-induced immunity self-reported symptoms. In...
In November 2016, the Dutch Health Council recommended hepatitis B (HBV) screening for first-generation immigrants from HBV endemic countries. However, these communities show relatively low attendance rates programmes, and our knowledge on their participation behaviour is limited. We identified determinants associated with intention to request an test in Moroccan-Dutch immigrants. also investigated influence of non-refundable costs intention.Offline online questionnaires were distributed...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Abstract Background In the Netherlands, all women aged 30–60 years are invited to participate in national cervical cancer screening programme, which is aimed at early detection and treatment of precancerous lesions. One fourth Dutch population has a migration background, with Turkish Moroccan immigrants being largest immigrant populations. Turkish‐ Moroccan‐Dutch show lower participation rates higher incidence cancer, compared native women. Since current information materials not tailored...
Abstract Pandemics are outbreaks of an infectious disease that increase morbidity and mortality over a wide geographic area. These events require large‐scale interventions from governments health agencies to curtail transmission within population. In assessing the impact these interventions, policymakers avail themselves simulations compartmental models. However, it is commonplace modellers employ fixed fractions represent which implicitly assume resources instantaneously boundlessly adjust...
Objectives Precarious employment (PE) is a social determinant of poor health workers. However, this population usually lack sampling frame, making it challenging to identify the characteristics group. Web-based respondent driven (webRDS) recruits individuals online through network and can provide estimates. This study aims assess performance webRDS in workers with PE. Method WebRDS was used for recruitment data collection PRecarious EMployment In Stockholm (PREMIS) study. Cross-sectional...
Abstract Background Electronic health (eHealth) interventions are promising in HIV and sexually transmitted infections (STIs) prevention among men who have sex with (MSM), given a high rate of the Internet use this population. This study determined preferences for eHealth to prevent STIs MSM Hanoi, Vietnam guide development future interventions. Methods Five focus group discussions (FGD) were conducted 35 recruited by purposive sampling January 2018 Vietnam. The FGDs addressed attitudes...