A5040799614- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Nosocomial Infections in ICU
- Microscopic Colitis
- Viral gastroenteritis research and epidemiology
- Antibiotic Resistance in Bacteria
- Botulinum Toxin and Related Neurological Disorders
- Bacterial Identification and Susceptibility Testing
- Geriatric Care and Nursing Homes
- Antimicrobial Resistance in Staphylococcus
- Gastrointestinal motility and disorders
- Genetic factors in colorectal cancer
- Food Security and Health in Diverse Populations
- Diabetes Treatment and Management
- Parkinson's Disease Mechanisms and Treatments
- Helicobacter pylori-related gastroenterology studies
- Escherichia coli research studies
- Pancreatic and Hepatic Oncology Research
- Antibiotics Pharmacokinetics and Efficacy
- Parasitic Infections and Diagnostics
- Pneumonia and Respiratory Infections
- Enterobacteriaceae and Cronobacter Research
- Esophageal Cancer Research and Treatment
- Diet and metabolism studies
- Streptococcal Infections and Treatments
Leiden University Medical Center
2019-2024
National Institute for Public Health and the Environment
2020-2024
Loyola University Medical Center
2023
Leiden University
2019
Erasmus MC
2017-2019
Amsterdam University Medical Centers
2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2017
Multidrug-resistant (MDR) bacteria are a growing global threat, especially in healthcare facilities. Faecal microbiota transplantation (FMT) is an effective prevention strategy for recurrences of Clostridioides difficile infections and can also be useful other microbiota-related diseases.
ObjectivesClostridium difficile is a major global human pathogen divided into five clades, of which clade 3 the least characterized and consists predominantly PCR ribotype (RT) 023 strains. Our aim was to analyse characterize this clade.MethodsIn cohort study clinical presentation C. RT023 infections analysed in comparison with known 'hypervirulent' non-hypervirulent strains, using data from Netherlands national surveillance programme. European strains diverse origin were collected...
The Netherlands Donor Feces Bank provides standardized ready-to-use donor faecal suspensions for microbiota transplantation treatment of patients with recurrent Clostridioides difficile infection.The purpose this study was evaluation safety, feasibility and outcome facilitated by a national stool bank.The methods used included: observational cohort donors recipients suspensions; assessment screening patient selection performed an expert panel medical microbiologists, gastroenterologists...
Abstract Background Nursing home residents have increased rates of intestinal colonisation with multidrug-resistant organisms (MDROs). We assessed the and spread MDROs among this population, determined clinical risk factors for MDRO investigated role gut microbiota in providing resistance against MDROs. Methods conducted a prospective cohort study Dutch nursing home. Demographical, epidemiological data were collected at four time points 2-month intervals (October 2016–April 2017). To obtain...
Abstract Background Patients with multiple recurrent Clostridioides difficile infections (rCDI) are treated fecal microbiota transplantation (FMT), using feces provided by healthy donors. Blastocystis colonization of donors is considered an exclusion criterion, whereas its pathogenicity still under debate. Methods The introduction molecular screening for sp. at our stool bank identified 2 prior negative microscopies but positive polymerase chain reactions (PCRs). Potential transmission to...
During the COVID-19 pandemic, several factors, such as improved hand hygiene, social distancing, and restricted hospital referral, may have had an influence on epidemiology of Clostridioides difficile infections (CDI).The annual CDI incidence rate nine hospitals participating in Dutch sentinel CI surveillance with complete data was compared between 2020 previous five years. Trends characteristics hospitalised patients 21-24 were first (March 13-May 12, 2020) or second wave (September 17,...
Introduction Experimental studies suggest a role of gut microbiota in the pathophysiology Parkinson’s disease (PD) via gut–brain axis. The can also influence metabolism levodopa, which is mainstay treatment PD. Therefore, modifying by faecal transplantation (FMT) could be supportive strategy. Methods and analysis We have developed study protocol for single-centre, prospective, self-controlled, interventional, safety feasibility donor-FMT pilot with randomisation double-blinded allocation...
In this retrospective observational study, we analysed a community outbreak of impetigo with meticillin-resistant Staphylococcus aureus (MRSA), additional resistance to fusidic acid (first-line treatment). The occurred between June 2018 and January 2020 in the eastern part Netherlands an epidemiological link three cases from north-western part. Forty nine eight carrier were identified, including 47 children. All but one case had community-onset symptoms. Pharmacy prescription data for...
OBJECTIVE To assess the mechanistic effects of glucagon-like peptide 1 (GLP-1) receptor agonist liraglutide and dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin on (exocrine) pancreatic physiology morphology. RESEARCH DESIGN AND METHODS For this randomized, double-blind, parallel-group trial, 55 patients with type 2 diabetes treated metformin and/or sulfonylurea agents were included. Participants received 1.8 mg (n = 19), 100 or matching placebos 17) once daily for 12 weeks. The primary...
Colistin is a last-resort treatment option for infections with multidrug-resistant Gram-negative bacteria. However, colistin resistance increasing.A six-month prospective matched case-control study was performed in which 22 Dutch laboratories 32 associated hospitals participated. Laboratories were invited to send maximum of five colistin-resistant Escherichia coli or Klebsiella pneumoniae (COLR-EK) isolates and colistin-susceptible (COLS-EK) the reference laboratory, patient location,...
The microbiota of the gut contributes to human mental health through gut-brain axis. Treatment with fecal transplantation (FMT) offers opportunity explore effects modification on in patients a perturbed after multiple recurrent Clostridioides difficile infections (rCDI). Symptoms anxiety and depression, as well self-rated health, happiness dispositional optimism were assessed pre-FMT (n = 49), post-FMT at 4 49) 26 weeks 34) 49 rCDI patients, treated FMT using feces from healthy donors....
Abstract Fecal microbiota transplantation (FMT) has been reported to decrease the incidence of recurrent urinary tract infections (UTIs), presumably by restoring microbiome diversity and/or uropathogen competition. We report a 16-year-old female with UTIs caused multidrug-resistant Klebsiella pneumoniae, for which frequent intravenous broad-spectrum antibiotic treatment was necessary. The patient treated FMT from well-screened healthy donor without bacteria in feces. After FMT, she developed...
Abstract Several experimental studies suggest a role of the gut microbiota in pathophysiology Parkinson’s disease (PD) via gut-brain axis. In addition, can influence metabolism levodopa, which is mainstay treatment PD. Therefore, modifying by fecal transplantation (FMT) could be supportive strategy. We developed study protocol for single center, prospective, self-controlled, interventional, safety and feasibility donor-FMT pilot with randomization double blinded allocation donor feces. The...
Multidrug-resistant (MDR) bacteria are a growing global threat, especially in healthcare facilities. Faecal microbiota transplantation (FMT) is an effective prevention strategy for recurrences of _Clostridioides difficile _infections (rCDI) and can also be useful other microbiota-related diseases. We study the effect FMT patients with rCDI on colonisation MDR antibiotic resistance genes (ARG) short (3 weeks) long term (1-3 years), combining culture methods faecal metagenomics. Based (n=87...