A5047496139- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Dementia and Cognitive Impairment Research
- Hip and Femur Fractures
- Blood Pressure and Hypertension Studies
- Anesthesia and Neurotoxicity Research
- Cancer-related cognitive impairment studies
- Health Systems, Economic Evaluations, Quality of Life
- Glioma Diagnosis and Treatment
- Nutritional Studies and Diet
- Bone health and osteoporosis research
- Frailty in Older Adults
- Diabetes and associated disorders
- Cerebrovascular and Carotid Artery Diseases
- Pelvic and Acetabular Injuries
- Cardiovascular Health and Disease Prevention
- Emergency and Acute Care Studies
- Aging and Gerontology Research
- Healthcare Policy and Management
- Anesthesia and Sedative Agents
- Neural and Behavioral Psychology Studies
- Iron Metabolism and Disorders
- Atrial Fibrillation Management and Outcomes
- Diet and metabolism studies
- Pituitary Gland Disorders and Treatments
University Medical Center Groningen
2012-2021
University of Groningen
2012-2021
Vrije Universiteit Amsterdam
2014
Isala
2013
Leiden University Medical Center
1999-2003
General Department of Preventive Medicine
2000
Leiden University
1992-1998
ContextWhether hemoglobin concentrations defined as anemia by the World Health Organization (WHO) are associated with increased mortality in older persons is not known.ObjectiveTo investigate association between concentration and cause-specific persons.DesignCommunity-based study conducted from 1986 to 1996 (follow-up period, 10 years).SettingLeiden, Netherlands.ParticipantsA total of 1016 community residents aged 85 years were eligible 872 agreed have a blood sample taken. Hemoglobin was...
Delirium is often unrecognized in ICU patients and associated with poor outcome. Screening for delirium recommended by several medical organizations to improve early diagnosis treatment. The Confusion Assessment Method the (CAM-ICU) has high sensitivity specificity when administered research nurses. However, test characteristics of CAM-ICU as performed routine practice are unclear.To investigate diagnostic value daily practice.Teams three experts including psychiatrists, geriatricians,...
Surgery for hip fractures is frequently followed by complications that hinder the rehabilitation of patients. The aim this study was to describe incidence rate and type complications, including mortality, after fracture surgery, identify risk factors these may be amenable prevention.Prospective cohort all consecutive patients aged ≥60 treated a at University Medical Center Groningen between July 2009 June 2013. All were in comprehensive multidisciplinary care pathway. Logistic regression...
<h3>Abstract</h3> <b>Objective:</b> To determine whether the inverse relation between blood pressure and all cause mortality in elderly people over 85 years of age can be explained by adjusting for health status, to high is a risk factor when effects poor are accounted for. <b>Design:</b> 5 7 year follow up community residents aged older. <b>Setting:</b> Leiden, Netherlands. <b>Subjects:</b> 835 subjects whose was recorded 1987 1989. <b>Main outcome measure:</b> All mortality....
Background and Purpose— Cognitive decline occurs earlier than previously realized is already evident at the age of 45. Because cardiovascular risk factors are established for cognitive in old age, we investigated whether also associated with young middle-aged groups. Methods— The cross-sectional study included 3778 participants aged 35 to 82 years (mean 54 years) free disease stroke. function was measured Ruff Figural Fluency Test (RFFT; worst score, 0; best 175 points) Visual Association...
Hip fractures frequently occur in older persons and severely decrease life expectancy independence. Several care pathways have been developed to lower the risk of negative outcomes but most are limited only one aspect care. The aim this study was therefore develop a comprehensive pathway for with hip fracture conduct preliminary analysis its effect. A multidisciplinary patients aged 60 years or by team. new evaluated clinical trial historical controls. data intervention group were collected...
Is this person ill or just old? This question reflects the pondering mind of a doctor while interpreting complaints an elderly who seeks his help. Many doctors think that ageing is non-disease. Accordingly, various attempts have been undertaken to separate pathological from normal ageing. However, existence process distinct processes causing disease later in life can be questioned.Ageing accumulation damage somatic cells, leading cellular dysfunction, and culminates organ dysfunction...
Recent studies found different associations of cognitive function with albuminuria or estimated GFR (eGFR). Most were limited to the elderly did not take both renal variables into account. Therefore, this study analyzed association and eGFR in community-dwelling persons aged 35 82 years.
Previous studies have shown that, despite the higher risk of bleeding, elderly still benefit from taking anticoagulants if they a stringent indication. However, owing to relatively low number patients older than 90 years in these studies, it is unknown whether this also seen with eldest patients.To determine how bleeding and thrombosis associated age 70 who were treated vitamin K antagonist (VKA).A matched cohort study was conducted at service VKA between January 21, 2009, June 30, 2012. All...
[(18)F]fluorodeoxyglucose (FDG) PET imaging of the brain can be used to assist in differential diagnosis dementia. Group differences glucose uptake between patients with dementia and controls are well-known. However, a multivariate analysis technique called scaled subprofile model, principal component (SSM/PCA) aiming at identifying diagnostic neural networks diseases, have been applied less frequently. We validated an Alzheimer's Disease-related (AD) metabolic pattern using SSM/PCA it...
Objectives: To investigate whether a low peripheral blood lymphocyte count is associated with increased mortality risk in older persons and to determine this association could be ascribed ill health. Design: A cohort study total follow‐up period of 1,602 person years. Setting: Leiden, the Netherlands. Participants: Four hundred thirty‐six community‐dwelling residents aged 85 older. Measurements: Health status leukocyte differential counts were assessed at baseline. Lymphocyte subsets...
The Ruff Figural Fluency Test (RFFT) was developed to avoid the difficulties that were encountered in earlier tests of figural fluency. Although test characteristics RFFT seem be good and it is a valuable addition neuropsychological assessments, reference data are still scarce. To this aim, we required 2,404 community dwelling persons Groningen, Netherlands perform RFFT. All 1,651 with complete known educational level formed sample. Their age ranged from 35 82 years their primary school...
APOE genotype is associated with the risk of Alzheimer's disease. In present study, we investigated whether was cognitive function in predominantly middle-aged persons. a population-based cohort 4,135 persons aged 35 to 82 years (mean age (SD), 55 (12) years), measured Ruff Figural Fluency Test (RFFT; worst score, 0 points; best 175 points). (rs429358 and rs7412) determined by polymerase chain reaction. The mean RFFT score (SD) total 69 (26) points. Unadjusted, homozygous ε4 carriers 4.66...
To evaluate the effect of routine use Confusion Assessment Method for Intensive Care Unit (CAM-ICU) on diagnosis rate delirium in elderly Emergency Department (ED) patients and validity CAM-ICU ED setting.This was a prospective observational study tertiary care academic ED. We compared before implementation CAM-ICU, without screening tool, with after CAM-ICU. All consecutive aged 70 years or older were enrolled. The based chart review positive score. In subsample, presence evaluated...
It is generally assumed that type 2 diabetes increases the risk of cognitive dysfunction in old age. As frequently diagnosed before age 50, diabetes-related may also occur 50. Therefore, we investigated association with function people aged 35–82 years. In a cross-sectional study comprising 4,135 participants Prevention Renal and Vascular ENd-stage Disease (52% men; mean (SD), 55 (12) years) was defined according to criteria American Diabetes Association. Executive measured Ruff Figural...
This study aimed to evaluate the influence that serum levels of vitamin B12, folate, and homocysteine have on development short-term postoperative cognitive decline in elderly surgical oncology patient.This was part a prospective cohort focused outcomes for patients 65 years age or older undergoing surgery solid malignancy. Postoperative defined as change combined results Ruff Figural Fluency Test Trail-Making Parts A B. Patients with highest scores 2 weeks postoperatively compared baseline...
SYNOPSIS The objective of this study was to describe over time the course cognitive function elderly without impairment and with different stages impairment, assess if change in dependent on initial level function. Mini-Mental State Examination (MMSE) used at two points. first assessment (MMSE-1) part a community-based obtained from 871 subjects. For second (MMSE-2) sample 166 subjects drawn alive follow-up who had an MMSE-1 score. This stratified by score avoid oversampling high scores. A...
We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with Ruff Figural Fluency Test (RFFT; worst score, 0; best 175 points) Visual Association (VAT; low performance, 0–10; high 11–12 in an observational study that included 4,095 community-dwelling participants aged 35–82 years. Data on were obtained from a computerized pharmacy database. Analysis done for total cohort subsamples matched cardiovascular risk (N = 1232) or propensity...