A5039663215- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Anesthesia and Neurotoxicity Research
- Frailty in Older Adults
- Enhanced Recovery After Surgery
- Cancer-related cognitive impairment studies
- Cancer, Stress, Anesthesia, and Immune Response
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Anesthesia and Sedative Agents
- Music Therapy and Health
- HIV/AIDS Research and Interventions
- Intestinal and Peritoneal Adhesions
- Stoma care and complications
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Cancer survivorship and care
- Pharmaceutical Economics and Policy
- Health and Well-being Studies
- HIV-related health complications and treatments
- IoT and Edge/Fog Computing
- Liver Disease Diagnosis and Treatment
University Medical Center Groningen
2017-2025
University of Groningen
2017-2024
Medisch Centrum Leeuwarden
2024
Amsterdam University Medical Centers
2020-2023
University of Amsterdam
2020-2023
Stichting HIV Monitoring
2023
Abstract Background Accurate quality of life (QoL) data and functional results after cancer surgery are lacking for older patients. The international, multicenter Geriatric Oncology Surgical Assessment Functional rEcovery Surgery (GOSAFE) Study compares QoL before identifies predictors decline in QoL. Methods GOSAFE prospectively collected major elective on adults (≥70 years). Frailty assessment was performed postoperative outcomes recorded (30, 90, 180 days postoperatively) together with by...
The GOSAFE study evaluates risk factors for failing to achieve good quality of life (QoL) and functional recovery (FR) in older patients undergoing surgery colon rectal cancer.
Abstract Background Remote home monitoring might fill the perceived surveillance gap after hospital discharge. However, it is unclear whether older oncologic patients will be able to use required new digital technologies. The study aimed assess feasibility of postoperative remote for this population. Methods This observational cohort recruited aged 65 years or scheduled surgery. used a mobile application and activity tracker preoperatively until 3 months postoperatively. A subset additional...
Post-operative delirium (POD) is associated with increased morbidity and mortality rates in older patients. Neuroinflammation, the activation of intrinsic immune system brain, seems to be one mechanisms behind development POD. The aim this study was explore association between perioperative inflammatory response POD a cohort oncological patients need for surgery.In prospective study, 65 years oncologic surgery were included. Inflammatory markers C-reactive protein (CRP), interleukin-1 beta...
Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication in older patients with cancer and associated decreased quality of life increased disability mortality rates. Systemic inflammation resulting neuroinflammation considered important the pathogenesis POCD. The aim this study was to explore association between early surgery‐induced inflammatory response POCD within 3 months after surgery patients. Methods Patients ≥65 years need for solid tumor were included...
Accurate prognostic biomarkers would substantially improve surgical planning and decisions making yet no studies have been reported exploring the inflammatory response in surgically treated older patients with cancer. The aim of this study was to explore as potential factors for postoperative complications within 30 days cancer.Patients 65 years undergoing surgery removal a solid malignant tumour were included an observational cohort study. All occurring up postoperatively documented...
Abstract Background Because of perioperative splanchnic hypoperfusion, the gut wall becomes more permeable for intraluminal microbes to enter circulation, possibly contributing development complications. Hypoperfusion-related injured enterocytes release intestinal fatty acid binding protein (I-FABP) into plasma, which is used as proxy integrity. This study investigates occurrence integrity loss during oncologic surgery, measured by I-FABP change. Secondary relationship between compromised...
Abstract Background The proposed underlying mechanisms of anxiety and depression, postoperative neurocognitive disorder (NCD), each include immune system involvement. Therefore, the aims this study were to investigate incidence NCD 3 months after surgery among oncological patients undergoing evaluate role preoperative depression. Method A consecutive series (age ≥ 18 years) for removal solid tumors included (n = 218). Cognitive performance was assessed preoperatively at postoperatively....
Background Incidence of, and baseline characteristics associated with delirium in patients after cytoreduction surgery‐hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC), were subject of investigation. Methods The study was conducted among a consecutive series prospectively included who underwent CRS‐HIPEC at the University Medical Center Groningen, Netherlands, between February 2006 January 2015. A chart‐based instrument for during hospitalization used to identify symptoms not diagnosed...
We present a case of drug-induced immune thrombocytopenia (DITP) proven to be due ceftriaxone instead assumed tuberculostatic treatment in patient with miliary tuberculosis. It is important identify the culprit drug DITP avoid discontinuing essential treatment, especially when more than one implicated. In these cases additional analysis (drug-dependent platelet antibody testing) should considered prevent unnecessary replacement first-line regimen an alternative regime.
Postoperative neurocognitive disorder (pNCD) is common after surgery. Exposure to anaesthetic drugs has been implicated as a potential cause of pNCD. Although several studies have investigated risk factors for the development cognitive impairment in early postoperative phase, pNCD at 3 months less well studied. The aim this study was identify anaesthesia-related surgery.We analysed data obtained prospective observational patients aged ≥ 65 years who underwent surgery excision solid tumour....
Abstract Background Malnutrition is a common and significant problem in older adults. Insight into factors underlying malnutrition needed to develop strategies that can improve the nutritional status. Compromised intestinal integrity caused by gut wall hypoperfusion due atherosclerosis of mesenteric arteries aging gastrointestinal tract may adversely affect nutrient uptake. The presence compromised adults not known. aim this study provide proof-of-concept during daily activities. Methods...