A5081882663- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Parasitic Diseases Research and Treatment
- Antimicrobial Resistance in Staphylococcus
- Virology and Viral Diseases
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- Infectious Diseases and Tuberculosis
- Microbial infections and disease research
- Clostridium difficile and Clostridium perfringens research
- Infectious Diseases and Mycology
- Mycobacterium research and diagnosis
- Syphilis Diagnosis and Treatment
- Respiratory viral infections research
- Parvovirus B19 Infection Studies
- Reproductive tract infections research
- Immunodeficiency and Autoimmune Disorders
- Global Maternal and Child Health
- Neutropenia and Cancer Infections
- Viral Infections and Vectors
Leiden University Medical Center
2017-2024
Albert Schweitzer Ziekenhuis
2024
National Institute for Public Health and the Environment
2023
COVID-19 associated pulmonary aspergillosis (CAPA) is with increased morbidity and mortality in ICU patients. We investigated the incidence of, risk factors for potential benefit of a pre-emptive screening strategy CAPA ICUs Netherlands/Belgium during immunosuppressive treatment.A retrospective, observational, multicentre study was performed from September 2020-April 2021 including patients admitted to who had undergone diagnostics CAPA. Patients were classified based on 2020 ECMM/ISHAM...
A high prevalence of COVID-19 associated pulmonary aspergillosis (CAPA) has been reported, though histopathological evidence is frequently lacking. To assess the clinical significance Aspergillus species in respiratory samples mechanically ventilated patients, we implemented routine screening for tracheal aspirate (TA).
Schistosomiasis is a parasitic disease affecting over 250 million people in the tropics. In non-endemic regions, imported Schistosoma infections are commonly diagnosed by serology, but based on antibody detection an active infection cannot be distinguished from cured and it may take more than 8 weeks after exposure before seroconversion occurs. endemic populations, excellent results have been described diagnosing low-grade of adult worm-derived circulating anodic antigen (CAA) utilising...
Detection of Schistosoma eggs in stool or urine is known for its low sensitivity diagnosing light infections. Alternative diagnostics with better while remaining highly specific, such as real-time PCR and circulating antigen detection, are progressively used complementary diagnostic procedures but have not yet replaced microscopy. This study evaluates these alternative methods the detection infections absence Schistosomiasis presence was determined retrospectively 314 banked samples,...
The arthropod-borne Zika virus (ZIKV) is currently causing a major international public health threat in the Americas. This study describes isolation of ZIKV from plasma 29-year-old female traveler that developed typical symptoms, like rash, fever and headache upon return Suriname. complete genome sequence including 5' 3' untranslated regions was determined phylogenetic analysis showed isolate clustering within Asian lineage, close to other viruses have recently been isolated In addition,...
The diagnostic performance of a prospective, systematic screening strategy for COVID-19 associated pulmonary aspergillosis (CAPA) during the pandemic was investigated. Patients with admitted to ICU were screened CAPA twice weekly by collection tracheal aspirate (TA) Aspergillus culture and PCR. Subsequently, bronchoalveolar lavage (BAL) sampling performed in patients positive results clinical suspicion infection. Patient data collected from April 2020-February 2022. classified according 2020...
We describe a case of community-acquired pneumonia due to Chlamydia caviae in patient with no direct animal exposure, raising questions about the zoonotic reservoirs and potential transmission routes. Genotyping Chamydia isolates that cause should be performed for precise diagnosis initiate adequate infection control measures.
Abstract Purpose Study objectives were to estimate the cumulative incidence of death due different causes (CODs) and investigate effect invasive aspergillosis (IA) on each separate COD in a cohort older patients with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS) included Haemato-Oncology Foundation for Adults Netherlands (HOVON) 43 randomized controlled trial. Methods Pre-collected data from trial was obtained HOVON center relevant clinical information extracted....
World-wide, emerging triazole resistance increasingly complicates treatment of invasive aspergillosis (IA). In settings with substantial (>10%) prevalence resistance, empiric combination therapy both a and liposomal amphotericin B (LAmB) can be considered because the low yields susceptibility testing. To avoid toxicity while optimizing outcome, strategy monotherapy would preferable. A newly designed algorithm based on literature expert consensus provided guidance for either voriconazole or...