A5064012002- Bone health and treatments
- Venous Thromboembolism Diagnosis and Management
- TGF-β signaling in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Cancer Cells and Metastasis
- Blood Coagulation and Thrombosis Mechanisms
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Management of metastatic bone disease
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Medical Imaging Techniques and Applications
- Connective Tissue Growth Factor Research
- Cancer, Stress, Anesthesia, and Immune Response
- Medical Imaging and Pathology Studies
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Inflammatory mediators and NSAID effects
- bioluminescence and chemiluminescence research
- Kruppel-like factors research
- Extracellular vesicles in disease
- Bone and Dental Protein Studies
Leiden University Medical Center
2014-2024
Leiden University
2008-2022
Indiana University School of Medicine
2011-2015
Indiana University – Purdue University Indianapolis
2011-2015
KU Leuven
2013
University of Bern
2010
University of Oxford
2010
University of Sheffield
2010
Metastatic progression of advanced prostate cancer is a major clinical problem. Identifying the cell(s) origin in and its distant metastases may permit development more effective treatment preventive therapies. In this study, aldehyde dehydrogenase (ALDH) activity was used as basis to isolate compare subpopulations primary human cells cell lines. ALDH-high displayed strongly elevated clonogenicity migratory behavior vitro. More strikingly, readily formed with enhanced tumor at both...
Abstract Transforming growth factor β (TGF-β) can act as suppressor and promoter of cancer progression. Intracellular Smad proteins (i.e., receptor regulated Smads common mediator Smad4) play a pivotal role in mediating antimitogenic proapoptotic effects TGF-β, but their function TGF-β-induced invasion metastasis is unclear. Here, we have investigated the Smad4 cellular mouse model for breast Consistent with its tumor function, specific silencing NMuMG mammary gland epithelial cells using...
Abstract Bone morphogenetic protein 7 (BMP7) counteracts the physiological epithelial-to-mesenchymal transition (EMT), a process that is indicative of epithelial plasticity. Because EMT involved in cancer, we investigated whether BMP7 plays role breast cancer growth and metastasis. In this study, show decreased expression primary significantly associated with formation clinically overt bone metastases patients ≥10 years follow-up. line these clinical observations, inversely related to...
Brown adipose tissue (BAT) produces heat by burning TGs that are stored within intracellular lipid droplets and need to be replenished the uptake of TG-derived FA from plasma. It is currently unclear whether BAT takes up via TG-rich lipoproteins (TRLs), after lipolysis-mediated liberation FA, or a combination both. Therefore, we generated glycerol tri[(3)H]oleate [(14)C]cholesteryl oleate double-labeled TRL-mimicking particles with an average diameter 45, 80, 150 nm (representing small VLDL...
ABSTRACT Increased fracture risk is commonly reported in cancer patients receiving radiotherapy, particularly at sites within the field of treatment. The direct and systemic effects ionizing radiation on bone a therapeutic dose are not well-characterized clinically relevant animal models. Using 20-week-old male C57Bl/6 mice, irradiation (right hindlimb; 2 Gy) volume microarchitecture were evaluated prospectively by microcomputed tomography histomorphometry compared to contralateral-shielded...
High aldehyde dehydrogenase (ALDH) activity can be used to identify tumor-initiating and metastasis-initiating cells in various human carcinomas, including prostate cancer. To date, the functional importance of ALDH enzymes carcinogenesis, progression metastasis has remained elusive. Previously we identified strong expression ALDH7A1 cancer cell lines, primary tumors matched bone metastases. In this study, evaluated whether is required for acquisition a metastatic stem/progenitor phenotype...
Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial can switch to motile, mesenchymal epithelial-mesenchymal transition (EMT). Recently, it has been shown that EMT functionally linked prostate stem cells, which are not only critically involved in maintenance but also We showed treatment with the non-peptide αv-integrin antagonist GLPG0187 dose-dependently increased E-cadherin/vimentin ratio, rendering more epithelial, sessile...
Background While it has been challenging to establish prostate cancer patient‐derived xenografts (PDXs), with a take rate of 10‐40% and long latency time, multiple groups throughout the world have developed methods for successful establishment serially transplantable human PDXs using variety immune deficient mice. In 2014, Movember Foundation launched Global Action Plan 1 (GAP1) project support an international collaborative PDX program involving eleven groups. Between these consortium...
Renal cell carcinoma (RCC) can be complicated by a venous tumor thrombus (TT), of which the optimal management is unknown.This study sought to assess prevalence TT in RCC, its current management, and association with thromboembolism (VTE), arterial (ATE), major bleeding (MB), mortality.Patients diagnosed RCC between 2010 2019 our hospital were included followed from diagnosis until 2 years after, or an outcome interest (VTE, ATE, MB) death occurred, depending on analysis. Cumulative...
Glioblastoma patients are considered to be at high risk of venous thromboembolism (VTE) and major bleeding (MB), although reliable incidence estimates lacking. Moreover, the arterial (ATE) in these is largely unknown. Our aim was assess cumulative incidence, predictors, prognostic impact VTE, ATE, MB on subsequent complications mortality.Cohort study 967 consecutive diagnosed with glioblastoma between 2004-2020 two hospitals. Patients were followed from 6 months before date histopathological...
Abstract Interference with the microenvironmental growth support is an attractive therapeutic strategy for repressing metastatic tumor growth. Bone a highly dynamic tissue that continuously remodeled by bone resorption and subsequent formation. Growth factors supporting are released especially during resorption. Differently from most other tissues, drugs can limit local turnover, such as bisphosphonates, available bone. In present study, we tested hypothesis inhibition of turnover affect...
Breast cancer is the most prevalent among females worldwide leading to approximately 350,000 deaths each year. It has long been known that cancers preferentially metastasize particular organs, and bone metastases occur in ~70% of patients with advanced breast cancer. are predominantly osteolytic accompanied by increased fracture risk, pain, nerve compression hypercalcemia, causing severe morbidity. In matrix, transforming growth factor-β (TGF-β) one abundant factors, which released active...
Resistance to docetaxel is a major clinical problem in advanced prostate cancer (PCa). Although glucocorticoids (GCs) are frequently used combination with docetaxel, it unclear what extent GCs and their receptor, the glucocorticoid receptor (GR), contribute chemotherapy resistance. In this study, we aim elucidate role of GR docetaxel-resistant PCa order improve current therapies. expression was analyzed tissue microarray primary specimens from chemonaive docetaxel-treated patients, cultured...