A5089378370- Occupational and environmental lung diseases
- Prostate Cancer Treatment and Research
- Neuroendocrine Tumor Research Advances
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Wnt/β-catenin signaling in development and cancer
- Gestational Trophoblastic Disease Studies
- Genetic factors in colorectal cancer
- Hormonal and reproductive studies
- Ferroptosis and cancer prognosis
- Estrogen and related hormone effects
- Endoplasmic Reticulum Stress and Disease
- Chromatin Remodeling and Cancer
- Urinary and Genital Oncology Studies
- CRISPR and Genetic Engineering
Hammersmith Hospital
2024
Imperial College London
2015-2024
Resistance to docetaxel is a major clinical problem in advanced prostate cancer (PCa). Although glucocorticoids (GCs) are frequently used combination with docetaxel, it unclear what extent GCs and their receptor, the glucocorticoid receptor (GR), contribute chemotherapy resistance. In this study, we aim elucidate role of GR docetaxel-resistant PCa order improve current therapies. expression was analyzed tissue microarray primary specimens from chemonaive docetaxel-treated patients, cultured...
Abstract STK11 adnexal tumour is a recently described female genital tract tumour, usually identified in paratubal location, often associated with Peutz-Jeghers syndrome (PJS) and gene alterations most of the cases. Morphologically, this composed cells arranged variety patterns, including cords, trabeculae, tubules cystic acinar structures. The are only moderately pleomorphic mitotic activity variable. As express epithelial, sex cord stromal mesothelial markers, may be stromal, epithelial or...
Abstract Background When ectopically overexpressed, anticancer genes, such as TRAIL , PAR4 and ORCTL3 specifically destroy tumour cells without harming untransformed cells. Anticancer genes can not only serve powerful specific therapy tools but studying their mode of action reveal mechanisms underlying the neoplastic transformation, sustenance spread. Methods gene discovery is normally accidental. Here we describe a systematic, gain function, forward genetic screen in mammalian to isolate...