A5081333072- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Platelet Disorders and Treatments
- Diagnosis and Treatment of Venous Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Blood properties and coagulation
- Antiplatelet Therapy and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cell Adhesion Molecules Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Blood groups and transfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Central Venous Catheters and Hemodialysis
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- Blood transfusion and management
- Acute Ischemic Stroke Management
- Mast cells and histamine
- Blood Pressure and Hypertension Studies
- Acute Myocardial Infarction Research
- Hematopoietic Stem Cell Transplantation
- Case Reports on Hematomas
- Folate and B Vitamins Research
- Vitamin K Research Studies
University Health Network
2008-2025
Toronto General Hospital
1991-2025
Singapore National Eye Center
2025
University of Toronto
2013-2023
Toronto Public Health
2023
Technical University of Munich
2019
Soroka Medical Center
2017
Mount Sinai Hospital
2012
Hamilton General Hospital
2012
St Joseph's Health Centre
2005
Low-molecular-weight heparin is the standard treatment for cancer-associated venous thromboembolism. The role of with direct oral anticoagulant agents unclear.
We have identified and purified a platelet integral membrane protein (140,000 mol wt), using the KC4 monoclonal antibody specific for activated platelets, that is internal in resting platelets but exposed on (Hsu-Lin S.-C., C.L. Berman, B.C. Furie, D. August, B. 1984, J. Biol. Chem. 259: 9121-9126.). The expression of surface secretion-dependent. This has been named activation-dependent granule-external (PADGEM) protein. PADGEM distinct from glycoproteins identical to S12 antigen, GMP-140....
Patients with atrial fibrillation (AF) who use a direct oral anticoagulant (DOAC) and request elective surgery or procedure present common clinical situation yet perioperative management is uncertain.To investigate the safety of standardized DOAC strategy.The Perioperative Anticoagulation Use for Surgery Evaluation (PAUSE) cohort study conducted at 23 centers in Canada, United States, Europe enrolled screened patients from August 1, 2014, through July 31, 2018. Participants (n = 3007) had...
<h3>Background</h3> Some of the benefit statins for prevention cardiovascular disease may be due to their antithrombotic properties. Little is known about effect these drugs on development deep vein thrombosis. <h3>Materials and Methods</h3> We conducted a retrospective cohort study over an 8-year period by linking Ontario provincial health care administrative databases covering more than 1.4 million residents aged 65 years or older. excluded those with documented history atherosclerosis,...
Abstract Objective To determine the efficacy and safety of dalteparin postoperative bridging treatment versus placebo for patients with atrial fibrillation or mechanical heart valves when warfarin is temporarily interrupted a planned procedure. Design Prospective, double blind, randomised controlled trial. Setting 10 thrombosis research sites in Canada India between February 2007 March 2016. Participants 1471 aged 18 years older who required temporary interruption Intervention Random...
In patients with active cancer and venous thromboembolism, whether extended treatment a reduced dose of an oral anticoagulant is effective in preventing recurrent thromboembolic events decreasing bleeding unclear. We conducted randomized, double-blind, noninferiority trial blinded central outcome adjudication. Consecutive proximal deep-vein thrombosis or pulmonary embolism who had completed at least 6 months therapy were randomly assigned 1:1 ratio to receive apixaban (2.5 mg) full (5.0...
While the physiologic role of platelet microparticles may include a stable, physical dispersion concentrated surface procoagulant activity mechanism(s) vesiculation remains unknown.We demonstrate using flow cytometric methods central for ps integrin glycoprotein (GP) IIb-IIIa complex and its ligand tetrapeptide Arg-Gly-Asp-Ser (RGDS) binding site in vesiculation.Time-and calcium-dependent platelets response to ADP, collagen, thrombin, phorbol myristate acetate, thrombin peptide SFLLRN were...
Abstract Background: PNH is an acquired hematopoietic stem cell disorder leading to a partial or absolute deficiency of all glycophosphatidyl‐inositol (GPI)‐linked proteins. The classical approach diagnosis by cytometry involves the loss at least two GPI‐linked antigens on RBCs and neutrophils. While flow assays are more sensitive specific than complement‐mediated lysis Hams test, they suffer from several drawbacks. Bacterial aerolysin binds GPI moiety surface molecules causes normal but not...
Background The perioperative management of patients who take a direct oral anticoagulant (DOAC) for atrial fibrillation and require treatment interruption an elective surgery/procedure is common clinical scenario which best practices are uncertain. Perioperative Anticoagulant Use Surgery Evaluation (PAUSE) study designed to address this unmet need. We discuss the rationale PAUSE design analysis plan as well supporting DOAC protocol. Methods prospective with three parallel cohorts, one each...
Background: The incidence of pulmonary embolism has been increasing, but its case-fatality rate is decreasing, suggesting a lesser severity illness. clinical importance patients with isolated to the subsegmental vessels unknown. Objective: To determine recurrent venous thromboembolism in managed without anticoagulation. Design: Multicenter prospective cohort study. (ClinicalTrials.gov: NCT01455818) Setting: Eighteen sites between February 2011 and 2021. Patients: Patients embolism....
Summary Acute deep venous thrombosis (DVT) causes leg pain. Elastic compression stockings (ECS) have potential to relieve DVT-related pain by diminishing the diameter of distended veins and increasing blood flow. It was our objective determine whether ECS reduce in patients with acute DVT. We performed a secondary analysis SOX Trial, multicentre randomised placebo controlled trial active versus prevent post-thrombotic syndrome.The study 24 hospital centres Canada U.S. included 803 first...
Purpose: This study compares clinical characteristics of retinitis pigmentosa (RP) associated with mutations in the EYS and USH2A genes a Southeast Asian cohort. Methods: Prospective single-center families EYS- or USH2A-associated RP seen at Singapore National Eye Centre. Comprehensive ophthalmic evaluations, multimodal imaging, genetic testing, longitudinal follow-up identified clinically useful differentiating features between two genotypes. Results: A total 300 were enrolled, RP,...
<h3>Background</h3> Elevation of plasma homocyst(e)ine level is an independent risk factor for arterial and venous thrombosis. We studied the degree to which hyperhomocyst(e)inemia contributes development thromboembolism, using a retrospective case-control study design. <h3>Methods</h3> Cases were individuals with objectively confirmed thromboembolism no history atherosclerosis seen at Toronto Hospital Thrombosis Clinic, Toronto, Ontario, between January 1, 1996, July 31, 1998. Three...
Background Cocaine consumption has been associated with thrombosis of coronary and peripheral arteries. Since cocaine found to induce platelet activation in vitro, we sought establish whether induced vivo. Methods Results Chronically instrumented, conscious dogs were infused (1 mg/kg), norepinephrine (0.2 0.4 or saline intravenously over 1 minute. Activated canine platelets identified whole blood collected from an indwelling aortic catheter by flow cytometric detection the binding a...
Preliminary evidence suggests that use of antipsychotic drugs is associated with an increased risk venous thromboembolism.To evaluate the relationship between or antidepressant drug and thromboembolism among adults aged 65 years older.Retrospective cohort study using linked health care administrative databases over a nine year period.The entire province Ontario, Canada.Individuals exclusively prescribed either (n = 22,514), 75,649) thyroid replacement hormones (33,033), referent control...
Background: Patent foramen ovale (PFO) is present in 40% of patients with cryptogenic stroke and may be associated paradoxical emboli to the brain. Therapeutic options include antiplatelet agents, anticoagulation, percutaneous device surgical closure. We assessed hypothesis that there are differences rates recurrent TIA or between four treatment groups. Methods: Patients presenting from January 1997 PFO were followed prospectively until June 2003. Treatment choice was made on an individual...