A5059140681- Coronary Interventions and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Ion channel regulation and function
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Cardiomyopathy and Myosin Studies
- Inflammatory mediators and NSAID effects
- Intracranial Aneurysms: Treatment and Complications
- Mechanical Circulatory Support Devices
- Neuroscience and Neuropharmacology Research
- Adrenal and Paraganglionic Tumors
- Cardiac pacing and defibrillation studies
- Diabetes Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Statistical Methods in Clinical Trials
- Infective Endocarditis Diagnosis and Management
University of Maryland, Baltimore
2014-2025
University of Maryland Medical Center
2007-2024
University of Maryland, College Park
2014
Montefiore Medical Center
2013
Albert Einstein College of Medicine
2013
Icahn School of Medicine at Mount Sinai
2013
Emory University
2013
University of Maryland Medical System
2008
Stanford University
2006
China XD Group (China)
2006
Background —Long-QT syndrome (LQTS) is a disorder of ventricular repolarization characterized by prolonged QT interval, syncope, seizures, and sudden death. Recently, three forms LQTS have been shown to result from mutations in potassium or sodium ion channel genes: KVLQT1 for LQT1, HERG LQT2, SCN5A LQT3. I sK, an apparent subunit encoded KCNE1 on chromosome 21, regulates both HERG. This relationship makes likely candidate gene, because these genes are known cause the autosomal dominant...
CYP2C19 genotype-guided antiplatelet therapy following percutaneous coronary intervention is increasingly implemented in clinical practice. However, challenges such as selecting a testing platform, communicating test results, building decision support processes, providing patient and provider education, integrating methods to the translation of emerging evidence practice are barriers broad adoption. In this report, we compare contrast implementation strategies 12 early adopters, describing...
Background Studies have demonstrated increased risk of major atherothrombotic events in CYP2C19 loss‐of‐function (LOF) variant carriers versus non‐carriers treated with clopidogrel after percutaneous coronary intervention (PCI). We sought to evaluate real‐world outcomes the clinical implementation ‐guided antiplatelet therapy PCI. Methods and Results Data from 9 medical centers where genotyping was performed setting PCI were included. Alternative prasugrel or ticagrelor recommended for...
Despite a substantial evidence base, implementation of pharmacogenetics into routine patient care has been slow due to number non‐trivial practical barriers. We implemented Personalized Anti‐platelet Pharmacogenetics Program (PAP3) for cardiac catheterization patients at the University Maryland Medical Center and Baltimore Veterans Administration Patients' are offered CYP2C19 genetic testing, which is performed in our Clinical Laboratory Improvement Amendment (CLIA)‐certified Translational...
Background Long QT syndrome (LQT) is an inherited cardiac disorder that results in syncope, seizures, and sudden death. In a family with LQT, we identified novel mutation human ether-a-go-go –related gene (HERG) , voltage-gated potassium channel. Methods Results We used DNA sequence analysis, restriction enzyme digestion allele-specific oligonucleotide hybridization to identify the HERG mutation. A single nucleotide substitution of thymidine guanine (T1961G) changed coding sense from...
B-type natriuretic peptide (BNP) is chronically elevated in heart transplantation and reflects diastolic dysfunction, cardiac allograft vasculopathy, poor late outcome. This investigation studied peripheral gene expression signatures of BNP concentrations clinically quiescent transplant recipients an effort to elucidate molecular correlates beyond hemodynamic perturbations.We performed microarray analysis blood mononuclear cells 28 with clinical quiescence (absence dyspnea or fatigue; normal...
Autosomal-dominant long QT syndrome (LQT) is an inherited disorder, predisposing affected individuals to sudden death from tachyarrhythmias. To identify the gene(s) responsible for LQT, we identified and characterized LQT family consisting of 48 individuals. DNA was screened with 150 microsatellite polymorphic markers encompassing approximately 70% genome. We found evidence linkage phenotype chromosome 7(q35–36). Marker D7S636 yielded a maximum lod score 6.93 at recombination fraction (θ)...
Long QT syndrome (LQTS) is a heterogeneous disorder caused by mutations of at least five different loci. Three these, LQT1, LQT2, and LQT5, encode potassium channel subunits. LQT3 encodes the cardiac-specific sodium channel, SCN5A. Previously reported LQTS-associated SCN5A include recurring three amino acid deletion (ΔKPQ1505–1507) in four families, missense mutations. We have examined gene 88 index cases with LQTS, including Jervell Lange-Nielsen remainder Romano-Ward syndrome. Screening...
A 62-year-old presents with angina. He has been genotyped for a panel of drug metabolism enzymes through direct-to-consumer genetics company. His results reveal CYP2C19 *2/*2 genotype warning that poor metabolizers (PMs) may have "lack therapeutic effect clopidogrel (Plavix), resulting from failure to generate the active form drug." Stress testing suggests significant ischemic burden consequent need percutaneous coronary intervention (PCI), possible stent placement, and antiplatelet therapy....
Conventional hybrid revascularization (CHR) combines minimally invasive placement of an internal mammary artery graft to the anterior wall and percutaneous coronary intervention (PCI) non-anterior targets. In this study we assess perioperative midterm outcomes advanced (AHR) defined as combination single or multivessel (MV) totally endoscopic bypass grafting (TECAB) with PCI.In total, 90 AHR patients [median age 62 years (35-86)] were compared CHR 60 (35-85)] in terms mid-term outcomes. The...
Postoperative atrial fibrillation (AFib) is common in patients undergoing coronary artery bypass grafting. Little information available concerning AFib following minimally invasive cardiac surgery. The aim of our study was to assess the incidence after totally endoscopic (TECAB) grafting and investigate factors influencing its occurrence.Between 2001 2010, we performed TECAB 384 patients, 73% male, aged 60 (37-90) years. Single-vessel bypasses were 280 104 received multivessel...
Objective Hybrid coronary revascularization (HCR) is a treatment strategy for the of multivessel disease that combines advantages both minimally invasive surgical techniques and percutaneous intervention (PCI). The optimal sequence by which should be accomplished has not been determined. We investigated clinical outcomes in series patients planned HCR via robotically assisted totally endoscopic artery bypass (TECAB) standard PCI based on sequence. Methods A total 238 between 2001 2011 were...
Early stent thrombosis is a rare complication of percutaneous intervention and associated with significant 30-day mortality. We present novel case multiple recurrent early consistent spontaneous vaccine-induced thrombotic thrombocytopenia. were successfully able to manage this unusual condition through an interdisciplinary collaboration.