A5079913623- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Orthopaedic implants and arthroplasty
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Cardiac and Coronary Surgery Techniques
- Medical Imaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Optical Coherence Tomography Applications
- Cardiovascular Function and Risk Factors
- Electrospun Nanofibers in Biomedical Applications
- Central Venous Catheters and Hemodialysis
- Tissue Engineering and Regenerative Medicine
- Corrosion Behavior and Inhibition
- Photoacoustic and Ultrasonic Imaging
- Cell Adhesion Molecules Research
- Advanced Image Processing Techniques
University of Alabama at Birmingham
2015-2024
University of Alabama
2005-2023
Endomimetics (United States)
2021-2023
Birmingham VA Medical Center
2023
Villa Melitta
2011
Heart Foundation
2000
Vanderbilt University Medical Center
1998
Duke Raleigh Hospital
1995
Duke University
1995
Duke University Hospital
1995
Abstract Polyanhydrides based on a variety of aromatic and aliphatic dicarboxylic acids were developed as bioerodible carrier matrices for controlled delivery applications. The high hydrolytic reactivity the anhydride linkage provides an intrinsic advantage over other classes polymers in versatility control degradation rates. For example, using poly[bis( p ‐carboxyphenoxy) alkane anhydrides] models, with rates range 10 −1 to −4 mg/h/cm 2 obtained by changing from methyl hexyl group....
Vascular access is the lifeline for hemodialysis patients and single most important component of procedure. Arteriovenous fistula (AVF) preferred vascular patients, but nearly 60% AVFs created fail to successfully mature due early intimal hyperplasia development poor outward remodeling. There are currently no therapies available prevent AVF maturation failure. First, we showed regulatory role nitric oxide (NO) on by demonstrating that was reduced in an overexpressed endothelial synthase...
Treatment of microRNA-146a encapsulated liposomes reduces vascular inflammation by targeting multiple related components including endothelial cell, smooth muscle and macrophage activation as well foam cell formation.
Abstract Traditional approaches for in‐vitro pulsatile and fatigue testing of endovascular stents do not take into consideration the pathologies stented vessel their associated biomechanical effects. One important pathology is calcification, which may be capable inducing changes in wall leading to inhomogeneous distribution stresses combined with motion during cardiac cycle. These local property region adjacent could directly influence in‐vivo stent performance. Seven cases containing a...
Abstract Limited information exists regarding the in vivo stability of endovascular stents. Nine excised human vascular segments with implanted stents ( n = 16) manufactured from stainless steel, nickel‐titanium, tantalum, and cobalt‐based alloys were analyzed. The stent/tissue components separated using an established tissue dissolution protocol control explanted evaluated by digital optical electron microscopy. Metallic content surrounding tissues was measured mass spectroscopy. Surface...
Background Data on racial disparities in major adverse cardiovascular events (MACE) and hemorrhage (HEM) after percutaneous coronary intervention are limited. Factors contributing to these unknown. Methods Results PRiME-GGAT (Pharmacogenomic Resource Improve Medication Effectiveness-Genotype-Guided Antiplatelet Therapy) is a prospective cohort. Patients aged ≥18 years undergoing were enrolled followed for up 1 year. Racial risk of MACE HEM assessed using an incident rate ratio. Sequential...
A recent U.S. Food and Drug Administration report presented the currently available scientific information related to biological response metal implants. In this work, a multilevel approach was employed assess implant-induced biocorrosion-related inflammation in adjacent vascular tissue using mouse stent implantation model. The implications of biocorrosion on peri-implant were assessed at macroscopic level via vivo imaging histomorphology. Elevated matrix metalloproteinase activity,...
Arteriovenous (AV) grafts and fistulas used for hemodialysis frequently develop intimal hyperplasia (IH) at the venous anastomosis of graft, leading to flow-limiting stenosis, ultimately graft failure due thrombosis. Although high AV access blood flow has been implicated in pathogenesis potential role needle turbulence during is relatively unexplored. High turbulent stresses from jet that reach may contribute endothelial denudation vessel wall injury. This trigger molecular cellular cascade...
Endothelial progenitor cell (EPC)-capturing techniques have led to revolutionary strategies that can improve the performance of cardiovascular implant devices and engineered tissues by enhancing re-endothelialization angiogenesis. However, these are limited controversies regarding phenotypic identities EPCs as well their inability target prevent other afflictions associated with current therapies, namely, thrombosis neointimal hyperplasia. Therefore, goal this study was efficacy a...
Coronary artery disease (CAD) is a cardiovascular condition with high morbidity and mortality. Intravascular optical coherence tomography (IVOCT) has been considered as an optimal imagining system for the diagnosis treatment of CAD. Constrained by Nyquist theorem, dense sampling in IVOCT attains resolving power to delineate cellular structures/features. There trade-off between spatial resolution fast scanning rate coronary imaging. In this paper, we propose viable spectral-spatial...
<i>Background/Aims:</i> Despite advances in stent design, in-stent restenosis (ISR) remains a significant clinical problem. All implant metals exhibit corrosion, which results release of metal ions. Stainless steel (SS), alloy widely used stents, releases ions to the vessel wall and induces reactive oxygen species, inflammation fibroproliferative responses. The molecular mechanisms are unknown. TGF-β is known be involved responses vascular smooth muscle cells (VSMCs) restenosis,...
Cardiovascular disease is presently the number one cause of death worldwide. Current stents used to treat cardiovascular have a litany unacceptable shortcomings: adverse clinical events including restenosis, neointimal hyperplasia, thrombosis, inflammation, and poor re-endothelialization. We developed biocompatible, multifunctional, peptide amphiphile-based nanomatrix coating for stents. In this study, we evaluated ability coated stent simultaneously address issues facing current under...
Myocardial injury is associated with excess mortality in severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infections, but the mechanisms of are diverse. We describe a case stress-induced cardiomyopathy setting SARS-CoV-2 and influenza A coinfection. (Level Difficulty: Intermediate.)