A5047426715- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical Economics and Policy
- Antibiotic Resistance in Bacteria
- Pharmaceutical studies and practices
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Statistical Methods in Clinical Trials
- Antibiotic Use and Resistance
- Antiplatelet Therapy and Cardiovascular Diseases
- Urinary Tract Infections Management
- Cancer therapeutics and mechanisms
- Chemical Reaction Mechanisms
- Liver Disease and Transplantation
- Lipoproteins and Cardiovascular Health
- Genetics, Bioinformatics, and Biomedical Research
- Influenza Virus Research Studies
- Bacterial Identification and Susceptibility Testing
- Vaccine Coverage and Hesitancy
- Atrial Fibrillation Management and Outcomes
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Clinical practice guidelines implementation
- Venous Thromboembolism Diagnosis and Management
Mahidol University
2016-2024
Siriraj Hospital
2024
GTx (United States)
2020
University of Illinois Chicago
2015-2017
With advancements in pharmacogenomics research and genotyping technology, implementation of into clinical practice is now feasible. The aim this publication to serve as a tutorial for institutions interested developing services. Topics covered include resources needed, decision support establishment, choosing platform, challenges faced with service implementation. This provides practical advice, drawing upon experience two established Clinical characteristics, such age, body weight, renal...
Pharmacogenomics (PGx) is increasingly being recognized as a potential tool for improving the efficacy and safety of drug therapy. Therefore, several efforts have been undertaken globally to facilitate implementation process PGx into routine clinical practice. Part these include formation working groups on research, synthesis, dissemination data creation strategies. In Asia, Southeast Asian Research Network (SEAPharm) established enable strengthen research among various communities within...
Bloodstream infections (BSI) caused by carbapenem-resistant Enterobacterales (CRE) are associated with a high mortality rate. This study aimed to investigate factors 14-day and identify potential treatment option. A retrospective cohort was conducted on patients CRE-BSI in Thailand from 2015 2020. The multivariate Cox proportional-hazards model employed influencing mortality. Out of 134 diagnosed cases CRE-BSI, the all-cause rate 35.1%. most prevalent organism isolated Klebsiella pneumoniae...
Pharmacogenomics (PGx) is the use of human genomic information to avoid toxicity and optimize efficacy drug therapy in an individual. Hospital pharmacists are key persons facilitate incorporation PGx into clinical practice. relatively new Thai hospital pharmacists. Therefore, this study aimed evaluate knowledge, attitude, practice towards implementation.We conducted a cross-sectional questionnaire-based survey among 600 21 hospitals across Thailand. The questionnaire consisted 35 questions...
What is Known and Objective Carbapenem-resistant Enterobacteriaceae (CRE) are virulent gram-negative bacilli cause urgent healthcare problems worldwide. One of the main factors leading to emergence CRE antimicrobial consumption. The objective this study was assess how closely rate consumption prevalences carbapenem-resistant Escherichia coli (CR-EC) Klebsiella pneumoniae (CR-KP) correlated. Methods A retrospective performed at a university hospital in Thailand from January 2013 September...
Background: Enoxaparin is one of the widely used injectable anticoagulants requiring dose adjustment based on body weight and renal function. Unadjusted or inappropriately adjusted doses can lead to thromboembolic bleeding events, particularly in patients with advanced age. Objectives: This retrospective chart review study primarily aimed evaluate enoxaparin use, along exploring factors associated inappropriate use elderly population. Methods: Baseline characteristics, thrombotic receiving...
Objectives:The primary objective of this study was to assess an optimal dose direct oral anticoagulants (DOACs), complied with prescribing information using the Cockcroft and Gault (C-G) equation in patients renal impairment.The secondary evaluate consistency between prescribed information.Clinical outcomes, including recurrence stroke, venous thromboembolism (VTE), bleeding, were also evaluated. Materials methods:This retrospective included impairment who received their first DOACs 1...
Summary Aim This study was conducted to compare predictive accuracy of the available pharmacogenetics ( PG x)‐guided warfarin dosing algorithms derived from Caucasian, Asian, and mixed population identify a suitable algorithm for Thai population. Methods Ten different including East South‐East races were selected tested with clinical genetic data patients. Comparative performances these using mean dose error MDE ) between actual maintenance AWMD predicted generated by each algorithm,...
Abstract Introduction Despite the diverse roles of pharmacists in immunization, vaccinator role remains uncharted for Thai pharmacists. This survey assesses pharmacist attitudes, knowledge, and willingness as vaccinators, providing insights to enhance their pivotal contribution vaccination outcomes Thailand. Methods The encompassed three sections: respondent characteristics, attitudes toward role, knowledge. Disseminated via Pharmacy Council Thailand (PCT)'s email system, it received 400...
Background: Precision medicine beckons new horizons for therapy geared to one's genetics, lifestyle, and environmental determinants. Molecular, pathology, clinical diagnostics can be integrated provide pharmaceutical care. Aims: The value appeal of precision community pharmacists, knowledge attained, training programmes perceived as necessary were evaluated. Methods: Over 10 months, a published questionnaire, which was also digitally accessible during the COVID-19 outbreak, distributed by...
Inter-individual variability in drug responses is significantly influenced by genetic factors, underscoring the importance of population-specific pharmacogenomic studies to optimize clinical outcomes. In this study, we analyzed whole genome sequencing data from 949 unrelated Thai individuals and conducted an in-depth analysis 3239 genes involved pharmacokinetics, pharmacodynamics, or immune-mediated adverse reactions. We identified 43 single nucleotide polymorphisms (SNPs), 134 diplotypes,...
Background: The chronic kidney disease (CKD) clinic plays a vital role in providing comprehensive ambulatory care for patients with CKD. Pharmacists contribute to ensuring proper drug use and identifying potential drug-related problems (DRPs). However, the evaluation of DRPs early phase CKD clinic, particularly resource-limited countries, remains limited. Objective: This study aimed assess prevalence attending investigate associated categories, identify factors contributing patients....
The objective of this study was to determine the optimal dosage regimens biapenem and fosfomycin combination achieving desirable pharmacodynamic effects against multidrug-resistant Acinetobacter baumannii (MDR-AB) infections in pediatric patients.A total 120 clinical MDR-AB strains were collected from tertiary hospitals Thailand.Minimum inhibition concentrations (MICs) all isolates determined by broth microdilution method.Synergy studies performed using checkerboard method.The population...
Nonselective beta-blockers (NSBBs) may exacerbate ascites by impairing cardiac function. This study evaluated the impact of achieving a heart rate target 55-60 beats per minute (bpm) on ascites-related death and complications from worsening in patients with cirrhosis diuretic-responsive using NSBBs. A retrospective was conducted at Faculty Medicine Ramathibodi Hospital, Mahidol University (2012-2022) analyzed NSBBs (propranolol/carvedilol) for variceal bleeding prophylaxis. The outcomes were...
Chloroquine (CQ) exhibited promising in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the optimal dosage regimens remain unknown.Our objective was to explore chloroquine phosphate (CQP) for early achievement of virological clearance within 48-72 hours diminish in-hospital transmission front-line healthcare workers.A 10,000-subject Monte Carlo simulation performed calculate both probability efficacy and safety attainment (PTA) using pharmacokinetic...
Coronavirus disease 2019 (COVID-19) is an outbreak of acute respiratory illness caused by severe syndrome coronavirus 2 (SARS-CoV-2).Fourteen percent patients developed requiring oxygen therapy and approximately 5% have multi-organ dysfunction intensive care unit (ICU) treatment 1 .Multiple host factors were associated with severity including age ≥ 50 years, male sex, cardiovascular disease, diabetes, malignancy .However, there not been any medications or other therapeutic options presently...