A5076495472- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- Mosquito-borne diseases and control
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Viral Infections and Vectors
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- RNA and protein synthesis mechanisms
- Receptor Mechanisms and Signaling
- Congenital heart defects research
- Cardiovascular Issues in Pregnancy
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- CRISPR and Genetic Engineering
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Conditions and Treatments
- Cardiovascular and Diving-Related Complications
- Malaria Research and Control
- Pharmacogenetics and Drug Metabolism
- Antimicrobial Resistance in Staphylococcus
Chulalongkorn University
2010-2024
Bangkok Hospital
2012-2024
Severance Hospital
2022
Yonsei University
2022
LAC+USC Medical Center
2018
King Chulalongkorn Memorial Hospital
2007-2009
Pediatrics and Genetics
2003
University of Southern California
1996-2000
Children's Hospital of Los Angeles
1996-1999
Miami Children's Hospital
1999
Treatment options for high-risk Brugada syndrome (BrS) with recurrent ventricular fibrillation (VF) are limited. Catheter ablation is increasingly performed but a large study long-term outcome data lacking. We report the results of multicenter, international BRAVO (Brugada Ablation VF Substrate Ongoing Registry) treatment symptomatic BrS. enrolled 159 patients (median age 42 years; 156 male) BrS and spontaneous in BRAVO; 43 (27%) them had early repolarization pattern. All 5 an implantable...
We conducted a multicenter study to evaluate mapping and ablation of ventricular fibrillation (VF) substrates or VF triggers in early repolarization syndromes (ERS) J-wave syndrome (JWS).We studied 52 patients with ERS (4 women; median age, 35 years) recurrent episodes. Body surface electrocardiographic imaging endocardial epicardial electroanatomical both ventricles were performed during sinus rhythm for localization triggers, substrates, drivers. Ablations on defined as areas that had late...
a) To describe the postoperative course and outcome of cardiac surgery in children with recent respiratory syncytial virus (RSV) infection; b) to evaluate whether timing has any impact on outcome.Retrospective case series.Intensive care unit medical surgical wards a teaching pediatric hospital.Twenty-five (aged 25 days 3.5 yrs; median, 4 months) congenital heart disease who had within 6 months after RSV infection.None.We reviewed clinical all patients. The diagnoses included ventricular...
Objectives: To determine the prevalence of myocardial depression and its effect on clinical severity in patients with dengue hemorrhagic fever. Design: Clinical study. Setting: King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Patients: Ninety-one children (age 10.5 ± 2.9 yrs, male/female = 52/39) serologically or polymerase chain reaction-proven virus infection. Interventions: Left ventricular ejection fraction (EF) was measured. The proportions EF <50% were identified fever (DF, n...
Abstract Background Severe pulmonary hypertension (PH) in childhood is rare and can manifest as a life-threatening episode. We present 2 children with restrictive dietary habits severe secondary to scurvy iron deficiency anemia treatment outcome. Case presentation The first case 2-year-old boy who presented vomiting, diarrhea, fever. After rehydration, he had recurrent episodes of hypotension intermittent abdominal pain. Fluid resuscitation inotropic medication were given. Then suddenly...
BACKGROUND: Brugada syndrome (BrS) is a cardiac arrhythmia disorder that causes sudden death in young adults. Rare genetic variants the SCN5A gene encoding Na v 1.5 sodium channel and common noncoding at this locus are robustly associated with condition. BrS particularly prevalent Southeast Asia but underlying ancestry-specific factors remain largely unknown. METHODS: Genome sequencing of probands population-matched controls from Thailand was performed to identify rare SCN5A-SCN10A were...
Arrhythmia Ahlation with Nonfluoroscopic 3D Mapping. Introduction: Conventional mapping and ablation rely on fluoroscopy, which can result in imprecise positioning of the catheter long fluoroscopic exposure times. We evaluated a nonfluoroscopic three‐dimensional system, termed CARTO, compared results using this technique those conventional mapping. Methods Results: 88 arrhythmia ablations (79 patients) CARTO 100 (94 technique. The were separated into four groups: (1) AV nodal reentrant...
Background: Various minor cardiac rhythm abnormalities have been reported in patients with dengue virus infection. Previous studies used only random electrocardiograms (ECG) to assess the incidence of arrhythmias, and time when ECGs were undertaken was not systematically defined.Objectives: To evaluate arrhythmias heart rate variability children infection during convalescent stage using Holter monitoring.Methods: Overnight 18–24-hour monitoring performed 35 [mean (SD) age 11·7 (2·3) y] at...
Publicly available pharmacogenomics (PGx) databases enable translation of genotype data into clinically actionable information. As variation within pharmacogenes is population-specific, this study investigated the spectrum 25 relevant in Thai population (n = 291) from whole genome sequencing. The bioinformatics tool Stargazer was used for phenotype prediction, through assignment alleles and detection structural variation. Known unreported potentially deleterious PGx variants were identified....
The purpose of this study was to measure the serum level sICAM-1 and sE-selectin as markers for endothelial damage in patients with dengue fever (DF) hemorrhagic (DHF). Twenty-nine serologically-proven virus infection (age 10.6 +/- 2.4 years, 55% male, DF = 13 DHF 16) were enrolled. Serum samples collected from 25 healthy children 2.3 40% male) control group. A follow-up done at a mean interval 15.9 1.6 days. toxic stage significantly elevated compared its (494.1 107.4 versus 358.2 67.6...
The mechanism of shock in patients with dengue hemorrhagic fever (DHF) has not yet been fully understood. In this study, we investigated the possibility splanchnic venous pooling as a contributor for circulatory dysfunction these patients. Ultrasonographic studies portal vein and inferior vena cava were done 45 serologically or PCR-confirmed diagnosis virus infection. size cava, mean blood flow velocity right vein, modified congestion index compared between (DF, n = 20), DHF without (n 14),...
Background: Evidence of hepatocellular damage is common in dengue-infected individuals. Hepatocyte growth factor (HGF), a key cytokine responsible for liver regeneration, may play prognostic role dengue virus infection. Aim: To determine the relationship between serum HGF level and disease severity patients with Methods: Serum samples from 27 children [17 fever (DF), ten haemorrhagic (DHF)] serologically confirmed infection during febrile, toxic stages at follow-up were analysed HGF....
The purpose of this study was to investigate the role matrix metalloproteinase-9 (MMP-9) in pathogenesis vascular leakage patients with dengue virus infection. Serum samples from 24 children serologically confirmed infection (dengue fever [DF], 16; hemorrhagic [DHF], 8; age, 9.5+/-2.4 years; 67% male] were analyzed for MMP-9 during febrile and toxic stages at follow-up. obtained 7 healthy used as controls. levels found be lower (227.0+/-186.9 ng/ml) (150.9+/-151.7 than follow-up...