A5025306596- Pharmacogenetics and Drug Metabolism
- Receptor Mechanisms and Signaling
- Biosimilars and Bioanalytical Methods
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
National Science and Technology Development Agency
2021-2024
National Center for Genetic Engineering and Biotechnology
2024
The increasing availability of next generation sequencing (NGS) for personal genomics could promote pharmacogenomics (PGx) discovery and application. However, current tools analysis interpretation pharmacogenomic variants from NGS data are inadequate, as none offer comprehensive analytic functions in a simple, web-based platform. In addition, no exist to analyze human leukocyte antigen (HLA) genes determining potential risks immune-mediated adverse drug reaction (IM-ADR). We describe...
Inter-individual variability in drug responses is significantly influenced by genetic factors, underscoring the importance of population-specific pharmacogenomic studies to optimize clinical outcomes. In this study, we analyzed whole genome sequencing data from 949 unrelated Thai individuals and conducted an in-depth analysis 3239 genes involved pharmacokinetics, pharmacodynamics, or immune-mediated adverse reactions. We identified 43 single nucleotide polymorphisms (SNPs), 134 diplotypes,...