A5003425745- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- CAR-T cell therapy research
- Pneumothorax, Barotrauma, Emphysema
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- scientometrics and bibliometrics research
- Cell death mechanisms and regulation
- Acute Lymphoblastic Leukemia research
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- Neonatal Respiratory Health Research
- Psychosomatic Disorders and Their Treatments
- Chronic Myeloid Leukemia Treatments
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- bioluminescence and chemiluminescence research
- Pleural and Pulmonary Diseases
- Mental Health and Psychiatry
- Cancer Cells and Metastasis
- Lymphatic Disorders and Treatments
Olive View-UCLA Medical Center
2020-2024
University of Southern California
2009-2019
George Washington University
2015-2017
Stellenbosch University
2011-2013
Mayo Clinic in Florida
2012
Broad Center
2010-2011
Southern California University for Professional Studies
2011
Eli Lilly (United States)
2005
The University of Texas Southwestern Medical Center
2005
UCLA Medical Center
1997
Abstract Introduction In contrast to its role in breast cancer (BCa) initiation, estrogen signaling has a protective effect later stages, where receptor (ER)α loss associates with aggressive metastatic disease. We asked whether the beneficial of late-stage BCa is attributable recently reported estrogen-mediated antagonism pro-metastatic transcription factor Runx2. Methods MCF7/Rx2 dox cells were engineered lentivirus expressing Runx2 response doxycycline (dox). Cells treated and/or estradiol...
2501 Background: PRI-724 is a first-in-class modulator of Wnt signaling that inhibits the CREB binding protein and β-catenin interaction. In pre-clinical models, (active metabolite C82) increases p300/β-catenin promotes stem cell differentiation thereby eliminating tumor initiating cells increasing sensitivity to cytotoxic or targeted drugs. Methods: was given as continuous infusion X 7 days q 2 wks. There an initial accelerated dose escalation with one pt per level plan revert 3+3 after 640...
Some 1,857 highly cited reviews, namely those at least 1,000 times since publication to 2011, were identified using the data hosted on S cience C itation I ndex Expanded ™ database ( T homson R euters, N ew Y ork, NY ) between 1899 and 2011. The are disaggregated by date, citation counts, journals, W eb of ® euters) subject areas, life cycles, publications obel P rize winners. Six indicators, total publications, independent collaborative first‐author corresponding‐author single‐author...
Objective.: To report the high incidence of barotrauma in critically ill patients admitted to intensive care unit (ICU) with coronavirus disease 2019 (COVID-19) and discuss its implications. Design.: Retrospective cohort study. Setting.: ICU an academic county hospital Los Angeles, CA from March 15-June 20, 2020. Patients.: 77 COVID-19 pneumonia. 75 met inclusion criteria. Results.: 21% severe sustained (33% receiving IMV, 8% (NIV). There were no differences between non-barotrauma groups...
PARK2 (PARKIN) is an E3 ubiquitin ligase whose dysfunction has been associated with the progression of Parkinsonism and human malignancies, its role in cancer remains to be explored. In this study, we report that frequently deleted underexpressed glioma, low expression poor survival. Restoration significantly inhibited glioma cell growth both vitro vivo, whereas depletion promoted proliferation. attenuated Wnt- EGF-stimulated pathways through downregulating intracellular level β-catenin...
Abstract A simple, accurate, sensitive and robust assay that can rapidly specifically measure the death of target cells would have applications in many areas biomedicine particularly for development novel cellular- immune-therapeutics. In this study, we describe a cytotoxicity assay, termed Matador which takes advantage extreme brightness, stability glow-like characteristics recently discovered marine luciferases their engineered derivatives. The involves expression luciferase interest...
of Science over the periods 1990-1994 and 2004-2008.It was noted that publication volumes have increased sharply even while stock researchers has remained static.A number factors may account for rise including increase in Department Education subsidy, South African journals indexed to Web a shift focus fields with higher propensity.For example, it new growth area emerged field infectious diseases.The count by author institution showed collaboration foreign authors considerably across two is...
Previously, we demonstrated that survivin expression is CBP/β-catenin/TCF-dependent. Now, using NCI-H28 cells, which harbor a homozygous deletion of β-catenin, demonstrate transcription can similarly be mediated by nuclear γ-catenin. ICG-001, specific inhibitor binding to the N-terminus CBP, effectively attenuates expression. We γ-catenin TCF family members and specifically recruiting coactivator CBP drives particularly in β-catenin-deficient cells. also examined relative β-catenin 90 cases...
PURPOSE A three-arm randomized phase III trial in advanced colorectal cancer patients was designed to test whether substitution of an equivalent dose (1) l-leucovorin or (2) oral leucovorin would more effectively potentiate fluorouracil (5-FU) than standard intravenous (I.V.) (d,l)-leucovorin. PATIENTS AND METHODS total 926 chemotherapy-naive participated. Patients received one three treatments: (A) intensive-course 5-FU plus with I.V. (Immunex Corp, Seattle, WA) at 100 mg/m2 and 370 mg/m2;...
Abstract Chimeric Antigen Receptor-T (CAR-T) cell immunotherapy has produced dramatic responses in hematologic malignancies. One of the challenges field is lack a simple assay for detection CARs on surface immune effector cells. In this study, we describe novel luciferase-based assay, termed Topanga Assay, CAR expression. The utilizes recombinant fusion protein, called reagent, generated by joining extra-cellular domain CAR-target frame with one marine luciferases or their engineered...
Rationale, aims, and objective: To study the utility outcome of electronic specialty consultations between primary care physicians specialists at a large, multispecialty academic practice to determine best practices for this model.Method: Use common health platform provision ordering care. A new model was put in place which an consultation with specialist could substitute face-to-face certain defined conditions. The financial type set up Mayo Clinic. All from January 2009 September 2011...
In the present study we examined methylation status of glial fibrillary acidic protein (GFAP) gene promoter, analyzing various CG sites in both human and rat GFAP-expressing nonexpressing tissues. Moreover, studied specific different brain areas during postnatal development, cell cultures highly enriched neural- or non-neural-cell types (fibroblasts), gliomas. The obtained results do not support a simple correlation between demethylation expression GFAP but help to identify cluster 5''...
A 66-year-old male with a history of low back pain was found to have discitis and osteomyelitis. Biopsy PCR testing revealed Streptococcus cristatus infection. This bacteria does not typically cause disease, only few cases in the literature reported it infection bones or joints. case illustrates that vertebral osteomyelitis rare causative agent, S. cristatus, is possible can be identified PCR. Treatment requires long-term antibiotics tailored agent for minimum 6 weeks sometimes include...
3568 Background: CRC is generally characterized by aberrant Wnt signaling. signaling pathway genes AXIN2 and TCF7L2 complex control the proliferation differentiation of intestinal epithelial cells. Previous study showed polymorphisms in were associated with increase risk colon cancer. We tested hypothesis whether single nucleotide (SNPs) (rs7903146) (rs2240308, rs3923087) will predict clinical outcome a cohort mCRC pts treated first line FOLFIRI/BEV. Methods: Genomic DNA extracted from blood...