A5090427479- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Molecular Biology Techniques and Applications
- Appendicitis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- Neuroblastoma Research and Treatments
- Amoebic Infections and Treatments
- Diet and metabolism studies
- Medical research and treatments
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Treatments and Studies
- IgG4-Related and Inflammatory Diseases
- Cancer Risks and Factors
- Celiac Disease Research and Management
- Lung Cancer Research Studies
- Infective Endocarditis Diagnosis and Management
Collaborative Group (United States)
2023
Hospital Del Mar
2009-2022
Hospital del Mar Research Institute
2013-2022
Universitat Pompeu Fabra
2022
Universitat Autònoma de Barcelona
2018-2022
Parc de Salut
2010-2021
Centro de Investigación Biomédica en Red de Cáncer
2019-2021
Spanish National Cancer Research Centre
2021
Cancer Research Center
2021
Centro de Investigación Biomédica en Red
2020
To compare perioperative outcomes of pancreatoduodenectomy (PD) performed through the laparoscopic route or by open surgery.Laparoscopic PD is being progressively in selected patients.An open-label single-center RCT was conducted between February 2013 and September 2017. The primary endpoint length hospital stay (LOS). Secondary endpoints were operative time, transfusion requirements, specific pancreatic complications (pancreatic biliary fistula, hemorrhage, delayed gastric emptying),...
Abstract Background: Despite smoking being a well-established risk factor for pancreatic cancer, there is need to further characterize cancer according lifespan patterns and other features, such as tobacco type. Our aim was deeply investigate them within large European case–control study. Methods: Tobacco habits relevant information were obtained from 2,009 cases 1,532 controls recruited in the PanGenEU study using standardized tools. Multivariate logistic regression analysis performed...
Objectives To characterise the association between type 2 diabetes mellitus (T2DM) subtypes (new-onset T2DM (NODM) or long-standing (LSDM)) and pancreatic cancer (PC) risk, to explore direction of causation through Mendelian randomisation (MR) analysis assess mediation role body mass index (BMI). Design Information about related factors was collected from 2018 PC cases 1540 controls PanGenEU (European Study into Digestive Illnesses Genetics) study. A subset had glycated haemoglobin,...
Background Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective The aim of this study was investigate the association adipose muscle parameters severity grade AP. Methods In total 454 patients were recruited. first contrast‐enhanced computed tomography each patient reviewed for tissue at L3 level. Associations analysed through logistic regression analysis. predictive capacity...
Family history (FH) of pancreatic cancer (PC) has been associated with an increased risk PC, but little is known regarding the role inherited/environmental factors or that FH other comorbidities in PC risk. We aimed to address these issues using multiple methodological approaches.
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk individuals of European descent, explaining 4.1% the phenotypic variance. We complemented new conventional (1D) genome spatial autocorrelation analysis (2D) permitting to prioritize low frequency variants not detected by GWAS. These were further expanded via Hi-C map (3D) interactions gain additional insight into inherited basis PC. In...
Bethesda guidelines are used to recognize patients at risk for Lynch syndrome. However, obtaining personal and familial tumor data can sometimes be difficult. The Microsatellite Path Score (MsPath), a pathological score, based on age, location, pathologic features, has been developed effectively predict colorectal cancer with DNA mismatch repair (MMR) deficiencies. the MsPath model's performance in an unselected, population-based (CRC) population is unknown.We analyzed all CRC regardless of...
Background Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. Aims To evaluate prevalence prognostic relevance pleuropulmonary pathologies pre-existing chronic lung diseases (CLD) in AP patients. Methods Multicentre retrospective cohort study. Caudal sections thorax derived from abdominal contrast enhanced computed tomography (CECT) performed phase were assessed. Independent predictors severe identified by binary logistic...
Deciphering the underlying genetic basis behind pancreatic cancer (PC) and its associated multimorbidities will enhance our knowledge toward PC control. The study investigated common background of different morbidities through a computational approach further evaluated less explored association between autoimmune diseases (AIDs) an epidemiological analysis. Gene‐disease associations (GDAs) 26 interest were obtained using DisGeNET public discovery platform. AIDs pointed by analysis was...
The most common aetiologies of acute pancreatitis (AP) are gallstones, alcohol and idiopathic. impact the aetiology AP on extent morphology pancreatic extrapancreatic necrosis (EXPN) has not been clearly established. aim present study was to assess influence presence location in patients with AP.We carried out a post-hoc analysis previously established multicentre cohort whom computed tomography available for review. Clinical data were obtained from medical records. All tomographies revised...
Abstract To demonstrate the efficacy of radiofrequency for pancreatic stump closure in reducing incidence postoperative fistula (POPF) distal pancreatectomy (DP) compared with mechanical transection methods. Despite all different techniques proposed DP, best practice avoiding POPF remains an unresolved issue, up to 30% regardless center volume or surgical expertise. DP was performed a cohort patients by applying (RF Group) and (Control Group). A propensity score (PS) matched study carried...