A5007736730- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Hair Growth and Disorders
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Histiocytic Disorders and Treatments
- Cancer Cells and Metastasis
- Cutaneous lymphoproliferative disorders research
- Sinusitis and nasal conditions
- Genetic and rare skin diseases.
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- AI in cancer detection
- Oral Health Pathology and Treatment
- Gut microbiota and health
- Skin and Cellular Biology Research
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Dermatologic Treatments and Research
- NF-κB Signaling Pathways
- Gastrointestinal motility and disorders
- Cutaneous Melanoma Detection and Management
- Contact Dermatitis and Allergies
- Pancreatic and Hepatic Oncology Research
- Cancer and Skin Lesions
Hospital Del Mar
2020-2024
Hospital del Mar Research Institute
2019-2023
Municipal Institute for Medical Research
2023
Parc de Salut
2021-2022
Universitat Autònoma de Barcelona
2019-2022
Centro de Investigación Biomédica en Red de Cáncer
2019-2020
The University of Texas MD Anderson Cancer Center
2020
Phosphorylated IKKα(p45) is a nuclear active form of the IKKα kinase that induced by MAP kinases BRAF and TAK1 promotes tumor growth independent canonical NF-κB signaling. Insights into sources activation its downstream substrates in nucleus remain to be defined. Here, we discover rapidly activated DNA damage ATM-ATR, but dependent on BRAF-TAK1-p38-MAPK, required for robust ATM efficient repair. Abolishing or activity attenuates ATM, Chk1, MDC1, Kap1, 53BP1 phosphorylation, compromises RIF1...
Abstract The objective of the study was to assess pathogenic and treatment relevance Platelet Activating factor (PAF) in chronic spontaneous urticaria (CSU). expression cellular location PAF receptor (PAFR) serum levels acetylhydrolase (PAF‐AH) patients with moderate/severe CSU ( n = 45) healthy controls (HCs, 17) were studied. Skin samples from active wheal (LS‐CSU, 13 for qPCR 33 immunohistochemistry) non‐lesional skin (NLS‐CSU, samples) HCs (13 5 analyzed. Serum PAF‐AH measured by ELISA...
Different immunohistochemical markers to detect amastigotes in cutaneous leishmaniasis have been proposed with variable diagnostic usefulness.To evaluate the usefulness of identification by specific polyclonal anti-Leishmania antibodies and CD1a expression (clone EP3622) a series PCR confirmed leishmaniasis.Thirty-three skin samples corresponding were included study. All stained Hematoxylin-eosin Giemsa. Moreover, studies anti-CD1a performed. The patients clinical features observed...
The human gut includes plasma cells (PCs) expressing immunoglobulin A1 (IgA1) or IgA2, two structurally distinct IgA subclasses with elusive regulation, function, and reactivity. We show here that intestinal IgA1+ IgA2+ PCs co-emerged early in life, comparably accumulated somatic mutations, were enriched within short-lived CD19+ long-lived CD19− PC subsets, respectively. extensively clonally related to a subset of them presumably emerged from precursors. Of note, secretory IgA1 (SIgA1) SIgA2...
The intestinal epithelium is a paradigm of adult tissue in constant regeneration that supported by stem cells (ISC). mechanisms regulating ISC homeostasis after injury are poorly understood. We previously demonstrated IκBα, not only controls NF-κB activation, but also exerts nuclear functions as cytokine sensor subset PRC2-regulated genes. have now detected phosphorylated IκBα (P-IκBα) the compartment where it binds highly histone methylated genomic regions. Mice deficient for show aberrant...
case report, contact dermatitis, drug-induced photosensitivity,