A5004434994- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Infant Development and Preterm Care
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Pediatric health and respiratory diseases
- Child and Adolescent Health
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Sepsis Diagnosis and Treatment
- Esophageal and GI Pathology
- Craniofacial Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Neonatal and fetal brain pathology
- Gut microbiota and health
- Congenital Heart Disease Studies
- Influenza Virus Research Studies
- Viral Infections and Immunology Research
- Gastroesophageal reflux and treatments
- Neonatal Health and Biochemistry
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2013-2025
Ospedale Santa Maria Goretti
2024
Bridge University
2012
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2009
Istituto di Sessuologia Clinica
1974-2003
University Hospital in Motol
2003
University of Ferrara
1995-2001
Paediatric fibreoptic bronchoscopy is used for ever wider indications, and increasingly in many contexts, including paediatric neonatal intensive care. The report of this Task Force contains an overview on the current applications bronchoscopy. discusses facilities equipment needed procedure, newly developed bronchoscopes which are allowing intervention even very small children. indications both flexible rigid context newer smaller endoscopic also considered. care instruments, disinfection...
To investigate the prevalence of 14 viruses in infants with bronchiolitis and to study demographic clinical differences those respiratory syncytial virus (RSV), human bocavirus (hBoV) rhinovirus (RV) infection.182 aged <12 months hospitalised for were enrolled. Infants underwent nasal washing detection RSV, influenza A B, coronavirus OC43, 229E, NL-63, HUK1, adenovirus, RV, parainfluenza 1-3, metapneumovirus hBoV. Demographic, laboratory data obtained from parents patient medical files. Main...
Objective: A supervised multivariate model to classify the metabolome alterations between autistic spectrum disorders (ASD) patients and controls, siblings of patients, has been realized used realize a network ASD patients' metabolome.Methods: In our experiment we propose quantification urinary metabolites with Mass Spectroscopy technique couple Gas Chromatography. extrapolate variables importance for interaction metabolites. this way are able network-based approach description.Results:...
<h3>Background</h3> Apnoea, desaturations and bradycardias are common problems in preterm infants which can be treated with nasal continuous positive airway pressure (NCPAP) intermittent ventilation (NIPPV). It is unclear whether synchronised NIPPV (SNIPPV) would even more effective. <h3>Objective</h3> To assess the effects of flow-SNIPPV, NCPAP on rate and, secondarily, to evaluate their influence pattern breathing gas exchange. <h3>Patients methods</h3> Nineteen (mean gestational age at...
Abstract Background : The aim was to investigate the role of physical and radiological findings before bronchoscopy in diagnosis foreign body aspiration (FBA). Methods We retrospectively reviewed clinical records for 82 patients (mean age 26.4 ± 21.4 months, range 9 months 13.5 years; 49 males) with a history suggestive aspiration. Results presence airways confirmed 70 children (85.4%) 25 14.1 45 boys). Of children, 63 (90%) were under 3 years age, peak incidence during second year. bodies...
Abstract Detection of a broad number respiratory viruses is not undertaken currently for the diagnosis acute infection due to large and always increasing list pathogens involved. A 1‐year study was on children hospitalized consecutively in Pediatric Department Rome characterize Two hundred twenty‐seven were enrolled with asthma, bronchiolitis, bronchopneumonia, or laringo‐tracheo bronchitis. molecular approach adopted using specific reverse transcription (RT)‐PCR assays detecting 13...
The association between bronchiolitis and recurrent wheezing remains controversial. In this prospective study, we assessed risk factors for during a 12-month follow-up in 313 infants aged <12 months hospitalised their first episode of bronchiolitis. Demographic, clinical laboratory data were obtained with questionnaire from medical files. A total 14 respiratory viruses concurrently assayed nasal washings. Parents interviewed 12 after hospitalisation to check whether experienced wheezing....
Abstract Background: Nasal flow‐synchronized intermittent positive pressure ventilation (NFSIPPV) is a new non‐invasive ventilatory mode that delivers synchronized mechanical breaths through the nasal prongs. An unmasked, prospective randomized controlled trial was conducted to compare efficacy of NFSIPPV and conventional continuous airway (NCPAP) in increasing likelihood for successful extubation very low‐birthweight infants. Methods: Consecutive infants who weighed <1251 g at birth,...
Bronchiolitis is the leading cause of hospitalization in infants under 12 months. Our aims were to analyze epidemiological characteristics with bronchiolitis over 10 consecutive seasons and evaluate whether there are any clinical differences between hospitalized for during epidemic peak months non-peak We enrolled 723 previously healthy term at Paediatric Emergency Department, "Sapienza" University Rome period 2004-2014. Fourteen respiratory viruses detected from nasopharyngeal aspirates by...
(1) Background: Our survey aimed to gather information on respiratory care in Neonatal Intensive Care Units (NICUs) the European and Mediterranean region. (2) Methods: Cross-sectional electronic survey. An 89-item questionnaire focusing current modes, devices, strategies employed neonatal units domain of was sent directors/heads 528 NICUs. The adherence “European consensus guidelines management distress syndrome” assessed for comparison. (3) Results: response rate 75% (397/528 units). In...
Links between respiratory syncytial virus bronchiolitis and asthma are well known, but few studies have dealt with wheezing following induced by other viruses. We assessed the risk factors for recurrent in infants hospitalised acute viral bronchiolitis.We followed 313 three years after they were bronchiolitis, caused 14 different viruses, to identify wheezing. Parents provided feedback on episodes during telephone interviews 12 (n = 266), 24 242) 36 230) months hospitalisation.The frequency...
To determine the incidence and predisposing factors for severe bronchiolitis in previously healthy term infants <12 months of age experiencing their first episode bronchiolitis.Epidemiological, clinical virological data were prospectively collected. Severity was assessed by need ventilatory support.Of 310 enrolled, 16 (5.1%) presented with requiring support (11 since admission). Compared less bronchiolitis, disease lower birth weight, gestational age, postnatal weight more likely to be born...
Bronchopulmonary dysplasia (BPD) or chronic lung disease is one of the principal causes mortality and morbidity in preterm infants. Early identification infants at greater risk developing BPD may allow a targeted approach for reducing severity complications. The trigger cause comprehends impairment alveolar development increased angiogenesis. Nevertheless, molecular pathways characterizing are still unclear. Therefore, use metabolomics technique, due to capability identifying instantaneous...
Bronchiolitis is the first lower respiratory tract viral infection manifesting in infants younger than 12 months of age. Our aim was to evaluate clinical and serological differences with bronchiolitis from a single or multiple viruses. secondary investigate recurrent wheezing episodes after 12‐24‐36 follow‐up. We reviewed records for 486 full‐term hospitalized at least one virus detected nasopharyngeal aspirate. In 431 (88.7%) patients 55 (11.3%) more found. No were observed length...
Preliminary results suggest that pertussis infection might be considered in infants during a seasonal respiratory syncytial virus (RSV) outbreak.In order to analyze clinical features and laboratory findings with hospitalized for acute symptoms RSV outbreak, we conducted retrospective single-center study on 19 (6 boys; median age 72 days) matched controls (RSV-bronchiolitis), from October 2008 April 2010. B. were detected nasopharyngeal washes Real Time-PCR.Infants less often breastfeed than...
We sought to know more about how 14 common respiratory viruses manifest clinically, and identify risk factors for specific virus-induced acute tract infections (ARTIs) in children younger than 3 years old wheezing at 36-month follow-up.We retrospectively studied the clinical records 273 full-term (median age, 2.9 months; range, 0.26-39; boys, 61.2%) hospitalized ARTIs, whose nasopharyngeal specimen tested positive a virus 101 with no history of diseases 8 0.5-36.5; 58.4%). At 12, 24 36...
We aimed to evaluate the policies and practices about neonatal resuscitation in a large sample of European hospitals.This was cross-sectional electronic survey. A 91-item questionnaire focusing on current delivery room domains individually sent directors 730 facilities or (in 5 countries) made available as Web-based link. comparison between hospitals with ≤2,000 those >2,000 births/year areas (Eastern Europe, Italy, Mediterranean countries, Turkey, Western Europe).The response rate 57%...
Abstract Background Our survey aimed to compare information on respiratory care in Neonatal Intensive Care Units (NICUs) Italy and the European Mediterranean region. Methods Cross-sectional electronic survey. An 89-item questionnaire focusing current modes, devices, strategies employed neonatal units domain of was sent directors/heads 528 NICUs. Results The response rate 75% (397/528 units). median number NICU beds admission per unit/year preterm infants < 1500 g significantly lower...
ABSTRACT Given the critical role of pattern recognition receptors (PRRs) in acid nucleic initiation innate immunity and orchestration adaptive immunity, aim this study was to determine whether any heterogeneity PRR expression airway tracts infants with respiratory syncytial virus (RSV) infection might explain broad clinical spectrum RSV-associated bronchiolitis infants. For purpose, levels melanoma differentiation-associated protein-5 (MDA-5), retinoic inducible gene-1 (RIG-1), Toll-like...