A5028579190- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- Metabolism and Genetic Disorders
- Birth, Development, and Health
- Diet and metabolism studies
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Autism Spectrum Disorder Research
- Gut microbiota and health
- Sepsis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Fatty Acid Research and Health
- Child Nutrition and Feeding Issues
- Cardiac Arrest and Resuscitation
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Pregnancy and preeclampsia studies
- Acute Kidney Injury Research
- Gestational Diabetes Research and Management
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience of respiration and sleep
- Sinusitis and nasal conditions
- Chemotherapy-induced cardiotoxicity and mitigation
University of Cagliari
2016-2025
University of Palermo
2023
Azienda Ospedaliero-Universitaria Cagliari
2013-2018
Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari
2013
Autism spectrum disorder (ASD) is a neurodevelopmental characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis (GBA) has been implicated in ASD although with limited reproducibility across studies. In this study, we developed Bayesian differential ranking algorithm to identify ASD-associated molecular taxa profiles 10 cross-sectional microbiome datasets 15 other datasets, including dietary patterns, metabolomics, cytokine human...
To date, we have little knowledge on the overall metabolic status of neonates with intrauterine growth retardation (IUGR). In last few years, analysis metabolomics has assumed an important clinical role in identifying "disorders" profile patients. The aim this work been to analyze urine profiles IUGR and compare them controls define patterns associated pathology. our knowledge, is first study performed IUGR. Recruited for were 26 diagnosed neonatal period weight at birth below 10th...
Objective: The aim of the present study was to investigate metabolic profile preterm human breast milk (HBM) by using a metabolomic approach. Methods: NMR spectroscopy and GC/MS were used analyze water-soluble lipid fractions extracted from samples obtained mothers giving birth at 26–36 weeks gestation. For sake comparison, formula also studied. Results: multivariate statistical analysis data evidenced biochemical variability both between HBM commercial within group samples. Conclusions:...
Objective: A supervised multivariate model to classify the metabolome alterations between autistic spectrum disorders (ASD) patients and controls, siblings of patients, has been realized used realize a network ASD patients' metabolome.Methods: In our experiment we propose quantification urinary metabolites with Mass Spectroscopy technique couple Gas Chromatography. extrapolate variables importance for interaction metabolites. this way are able network-based approach description.Results:...
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease occurring predominantly in premature infants whose etiology still not fully understood. In this study, the analysis of infant fecal samples through shotgun metagenomics approaches revealed marked reduction intestinal (bio)diversity and an overgrowth (opportunistic) pathogens associated with NEC development.
Twenty-two patients with clinical findings consistent osteomyelitis, soft-tissue infection, or both were studied magnetic resonance (MR) imaging at 1.5 T. Another 15 joint effusion but no laboratory signs of infection served as controls. Soft-tissue abscesses, and tendon sheath effusion, cellulitis well depicted on MR imaging, allowing the correct diagnosis presence extent in all two cases. was sensitive technetium-99m methylene diphosphonate bone scintigraphy demonstrating osteomyelitis...
Magnetic resonance (MR) images of the hips and knees three healthy volunteers were reviewed compared with obtained from patients effusions. Comparison was also made MR two swine following injections saline in one blood other. The anatomy well defined. hip effusions all easily recognized. clearly demonstrated experimentally produced joint introduced had long T1 T2 values allowing easy differentiation articular cartilage. We unable to distinguish fresh knee joints.
Autism spectrum disorders (ASD) make a dishomogeneous group of psychiatric diseases having either genetic and environmental components, including changes the microbiota. The rate diagnosis, based on series psychological tests observed behavior, dramatically increased in past few decades. Currently, no biological markers are available pathogenesis is not defined. purpose this study was to evaluate potential use 1 H‐NMR metabolomics analyze global biochemical signature ASD patients ( n = 21)...
Soluble CD14 subtype (sCD14-ST), also named presepsin, is a 13 kDa truncated form of soluble (sCD14), consisting 64 amino acid residues. Systemic inflammation and sepsis are characterized by an early, significant increase in sCD14-ST presepsin blood concentration thus, this small polypeptide has been proposed as novel, reliable biomarker for the management sepsis. We enrolled twenty-six consecutive non-septic preterm newborns with gestational age (GA) between 26 36 weeks) admitted to NICU...
Bronchopulmonary dysplasia (BPD) or chronic lung disease is one of the principal causes mortality and morbidity in preterm infants. Early identification infants at greater risk developing BPD may allow a targeted approach for reducing severity complications. The trigger cause comprehends impairment alveolar development increased angiogenesis. Nevertheless, molecular pathways characterizing are still unclear. Therefore, use metabolomics technique, due to capability identifying instantaneous...
Abstract Endometriosis is a common disease affecting women in reproductive age. There are several hypotheses on the pathogenesis of this disease. Often, its lesions and symptoms overlap with those many other medical surgical conditions, causing delay diagnosis. Metabolomics represents useful diagnostic tool for study metabolic changes during different physiological or pathological status. We used 1 H-NMR to explore alteration cohort patients endometriosis order contribute better...