A5035007672- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Ethics and Legal Issues in Pediatric Healthcare
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Pregnancy and preeclampsia studies
- Tracheal and airway disorders
- Disability Rights and Representation
- Maternal and Perinatal Health Interventions
- Spinal Dysraphism and Malformations
- Neonatal Respiratory Health Research
- Ethics in Clinical Research
- Childhood Cancer Survivors' Quality of Life
- Maternal and fetal healthcare
- Maternal Mental Health During Pregnancy and Postpartum
- Healthcare Policy and Management
- Palliative Care and End-of-Life Issues
- Emergency and Acute Care Studies
- Delphi Technique in Research
- Grief, Bereavement, and Mental Health
- Genetic and Kidney Cyst Diseases
- Parvovirus B19 Infection Studies
- Family and Patient Care in Intensive Care Units
- Autopsy Techniques and Outcomes
- Pregnancy and Medication Impact
University Medical Center Utrecht
2014-2025
KU Leuven
2020-2025
Wilhelmina Children's Hospital
2019-2024
Utrecht University
2016-2024
University College London
2020-2022
University College Hospital
2021-2022
Heidelberg University
2020
University Hospital Heidelberg
2020
Hospital admission during pregnancy complications is considered to be an event of significant impact. Besides conventional in-clinic maternal and fetal monitoring, recent technologies enable home-based telemonitoring with self-measurements in high risk pregnancy. This study part a feasibility pilot explore the usability acceptability aims gain insight experiences preferences pregnant women concerning novel strategy telemonitoring, opposed who were hospitalized pregnancy.Using secured...
Noninvasive prenatal testing by cell-free DNA analysis is offered to pregnant women worldwide screen for fetal aneuploidies. In noninvasive testing, the fraction of in maternal circulation measured as a quality control parameter. Given that originates from placenta, might also reflect placental health and pregnancy adaptation.
The offer of prenatal Down's syndrome screening is part routine antenatal care in most Europe; however uptake varies significantly across countries. Although a decision to accept or reject personal choice, it unlikely that the widely differing rates countries can be explained by variation individual values alone. aim this study was compare policies and programmes Netherlands, where relatively low (<30%) with England Denmark higher (74 > 90% respectively), an attempt explain observed national...
The Netherlands and Belgium have been among the first countries to offer non-invasive prenatal testing (NIPT) as a first-tier screening test. Despite similarities, differences exist in counseling modalities test uptake. This study explored decision-making perspectives of pregnant women who opted for NIPT both countries.A questionnaire was performed (NL) (n = 587) (BE) 444) opting NIPT, including measures on informed choice, personal societal trisomy 21, 18 13 pregnancy...
Objectives Noninvasive prenatal testing (NIPT) to screen for fetal aneuploidies by analysing cell-free DNA in maternal plasma is available pregnant women worldwide. In the future, scope of NIPT could potentially be expanded prediction adverse pregnancy outcomes. The objective this study was assess and compare preferences obstetric healthcare professionals on new test purpose NIPT. Design A discrete choice experiment designed participants’ use predict outcomes regarding three attributes...
(Abstracted from Am J Obstet Gynecol 2024;231:244.e1–244.e18) Noninvasive prenatal testing (NIPT) for Down, Edwards, and Patau syndromes is widely available. Its accuracy depends on a sufficient amount of fetal cell-free DNA (cfDNA) in maternal plasma.
Abstract Objectives First‐trimester ultrasound screening is increasingly performed to detect fetal anomalies early in pregnancy, aiming enhance reproductive autonomy for future parents. This study aims display the current practice of first‐trimester developed countries. Method An online survey among 47 prenatal experts Results structural anomaly available 30 33 countries and mostly offered all women with generally high uptakes. National protocols are 23/30 (76.7%) countries, but extent...
Uptake rates for Down syndrome screening in the Netherlands are low compared to other European countries. To investigate uptake, we explored women's reasons participation and possible influences of national healthcare system characteristics. Dutch prenatal care is characterised by an approach aimed at a degree medicalisation, with pregnant women initially considered be risk. Prenatal offered all women, 'right not know' who do want informed on this screening. At time study was performed, test...
Abstract Background and Aims Patient‐reported outcome experience measures (PROM PREM) can facilitate shared decision making hold potential to improve healthcare quality. However, their adoption in perinatal care is still limited. The International Consortium for Health Outcomes Measurement (ICHOM) developed a Pregnancy Childbirth (PCB) set, including PROM PREM questionnaires. We studied the feasibility use these PROMs/PREMs Dutch care, addressing both women's professionals' perspective....
To explore the concepts and strategies parents employ when considering maternal-fetal surgery (MFS) as an option for management of spina bifida (SB) in their fetus, how this determines acceptability intervention.A two-centre interview study enrolling whose fetuses with SB were eligible MFS. assess differences acceptability, opting MFS (n = 24) interviewed at three different moments time: prior to intervention, directly after intervention 3-6 months birth. Parents termination pregnancy 5)...
Abstract Objective To explore the prenatal trajectory and experiences of mothers a child with Down syndrome (DS) at time receiving information or test results when participating in nationwide screening program. Methods An online questionnaire study was completed by children DS born between January 1, 2010 February 28, 2016 ( n = 212). Data were collected 15 2016. Results Most live diagnosed postnatally. The majority their had explicitly chosen not to have screening. Of 39 prenatally informed...
To define the dimensions of patient-centeredness prenatal care for parents who had a fetus with isolated congenital diaphragmatic hernia (CDH) by exploring their values, experiences, needs and preferences.In-depth interviews were faced diagnosis CDH.Interviews (n = 18) identified seven patient-centeredness. Parental preferences are respected unconditional acceptance parental choices needs. After access to should occur swift referral specialised centre prevent receiving contradictory...
To improve early risk-identification in pregnancy, research on prediction models for common pregnancy complications is ongoing. Therefore, it was the aim of this study to explore pregnant women's perceptions, preferences and needs regarding first trimester screening complications, such as preeclampsia, support future implementation.Ten focus groups (of which five with primiparous multiparous women) were conducted (n = 45). Six urban regions four rural regions. All group discussions audio...
To improve their quality, healthcare systems are increasingly focused on value delivered to patients. For perinatal care, the International Consortium for Health Outcomes Measurement (ICHOM) proposed a patient-centred outcome set with both clinical and patient-reported measures pregnancy childbirth (PCB set). This study aimed identify factors that affect implementation of PCB at pre-implementation stage, using consolidated framework research (CFIR).
What's Already Known About This Topic? Women include their attitudes towards Down syndrome and termination of pregnancy, as well adverse test characteristics, in considerations about participation first‐trimester combined testing (FCT). Concerns have been raised the ‘routinisation’ prenatal screening with introduction non‐invasive using cell‐free DNA (cfDNA). What Does Study Add? who would decline FCT for test‐related reasons are possibly more likely to accept safer cfDNA test. relating...
Running randomized clinical trials (RCT) in fetal therapy is challenging. This no different for fetoscopic endoluminal tracheal occlusion (FETO) severe left-sided Congenital Diaphragmatic Hernia (CDH). We assessed the knowledge, attitude and practice (KAP) of maternal-fetal medicine specialists toward antenatal management CDH, controlled "Tracheal Occlusion To Accelerate Lung growth-trial."A cross-sectional KAP-survey was conducted among 311 registrants 18th World Congress Fetal Medicine.The...
To explore the perspectives of pregnant women on broadening scope noninvasive prenatal testing (NIPT) from screening for foetal aneuploidies to prediction adverse pregnancy outcomes.
IntroductionFamily planning and reproductive care are essential yet complex aspects of lifecycle management for individuals with Autosomal Dominant Polycystic Kidney Disease (ADPKD), given the potential genetic transmission pregnancy-related complications. This qualitative study studied experiences perspectives patients ADPKD clinicians to identify areas improvement in care.MethodsFocus group discussions were conducted Netherlands ADPKD, both men women, who had children through varied...