A5010651995- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Birth, Development, and Health
- Electrolyte and hormonal disorders
- Cardiovascular Issues in Pregnancy
- Maternal Mental Health During Pregnancy and Postpartum
- Gestational Diabetes Research and Management
- Pharmacological Effects and Toxicity Studies
- Maternal and fetal healthcare
- Pregnancy-related medical research
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Renal and related cancers
- COVID-19 Impact on Reproduction
- Ectopic Pregnancy Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Sarcoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Risks and Factors
- Pelvic and Acetabular Injuries
Radboud University Nijmegen
2008-2022
Radboud University Medical Center
2008-2022
Maastricht University
2019
University Medical Center
2019
Maastricht University Medical Centre
2016
ABSTRACT Objectives Pre‐eclampsia (PE) is associated with both postpartum structural asymptomatic heart disease (i.e. failure Stage B (HF‐B)) and conventional cardiovascular (CV) risk factors. We aimed to evaluate the extent which PE, adjusted for CV factors, independently cardiac abnormalities postpartum. Methods In this cross‐sectional cohort study, 107 formerly pre‐eclamptic women 41 uneventful previous pregnancy (controls) were invited assessment 4–10 years This included ultrasound,...
ABSTRACT Objectives After pre‐eclampsia (PE), the prevalence of structural heart disease without symptoms, i.e. failure Stage B (HF‐B), may be as high one in four women first year postpartum. We hypothesize that a significant number formerly pre‐eclamptic with HF‐B postpartum are still their resolving period and will not have during follow‐up. Methods In this prospective longitudinal cohort study, we included 69 who underwent serial echocardiographic measurements at 1 4 years was diagnosed...
Pre-eclampsia (PE) is associated with both postpartum endothelial dysfunction and asymptomatic structural heart alterations consistent failure Stage B (HF-B). In this study, we assessed the relationship between function, measured by flow-mediated dilation (FMD), HF-B in women a history of PE.This was an observational study which 67 formerly pre-eclamptic (≥ 4 years postpartum) 37 healthy parous controls were ultrasonographically for cardiac function geometry, as well means brachial artery...
The COVID-19 pandemic led to regional or nationwide lockdowns as part of risk mitigation measurements in many countries worldwide. Recent studies suggest an unexpected and unprecedented decrease preterm births during the initial first half 2020. objective current study was assess effects two months national lockdown period on incidence very extremely birth Netherlands, stratified by either spontaneous iatrogenic onset delivery, both singleton multiple pregnancies.Retrospective cohort using...
Objective To determine the prevalence of depression, anxiety, and posttraumatic stress disorder (PTSD) years after hyperemesis gravidarum (HG) its association with HG severity.Material methods This prospective cohort study consisted a follow-up 215 women admitted for HG, who were eligible to participate in randomized controlled trial either declined or agreed be between 2013 2016 19 hospitals Netherlands. Participants completed Hospital Anxiety Depression Scale (HADS) six weeks postpartum...
Abstract Introduction Hyperemesis gravidarum (HG) complicates 1% of pregnancies and has a major impact on maternal quality life well‐being. We know very little about HG’s long‐term after an affected pregnancy, including recurrence rates in future pregnancies, which is essential information for women considering subsequent pregnancies. In this study, we aimed to prospectively measure the rate HG number postponed terminated due HG. also evaluate if there were predictive factors that could...
Hyperemesis gravidarum (HG), or intractable vomiting during pregnancy, is the single most frequent cause of hospital admission in early pregnancy. HG has a major impact on maternal quality life and repeatedly been associated with poor pregnancy outcome such as low birth weight. Currently, women are admitted to for intravenous fluid replacement, without receiving specific nutritional attention. Nasogastric tube feeding sometimes used last resort treatment. At present no randomised trials...
Preeclampsia (PE) is a pregnancy related endothelial disease characterized by hypertension and albuminuria. Postpartum dysfunction often persists in these women. We postulate that women with history of PE reduced dependent vasodilation coincides attenuated kidney function, as both reflect dysfunction.We assessed function (n=79) uncomplicated pregnancies (n=49) at least 4years postpartum. Women hypertension, diabetes or prior to were excluded. Brachial artery flow mediated dilatation (FMD)...
Little is known about the pathophysiology of hyperemesis gravidarum (HG). Proposed underlying causes are multifactorial and thyroid function hypothesized to be causally involved. In this study, we aimed assess utility thyroid-stimulating hormone (TSH) free thyroxine (FT4) as a marker predictor for severity clinical course HG.We conducted prospective cohort study including women admitted HG between 5 20 weeks gestation in 19 hospitals Netherlands. Women with medical history disease were...
Background During uncomplicated pregnancy, left ventricular remodeling occurs in an eccentric way. In contrast, during preeclamptic gestation, the ventricle hypertrophies concentrically, concurrent with loss circulatory volume and increased blood pressure. Concentric cardiac structure persists a substantial proportion of women may be associated pressure load after preeclampsia. We hypothesize that low load, as indicated by plasma (PV) preeclampsia is remote concentric remodeling. Methods...
ABSTRACT Objective Prepregnancy reduced plasma volume (PV) increases the risk of subsequent pre‐eclamptic pregnancy. Reduced PV is thought to reflect venous reserve capacity, especially when vasculature constricted and sympathetic tone elevated. As obesity might affect these variables, associated with pre‐eclampsia, increased body weight may underlie observations. The aim this study was determine whether relationship between pre‐eclampsia independent mass index (BMI). Methods This an...
History of preeclampsia increases the risk cardiovascular disease in women. Most formerly, preeclamptic women have generally one or even more traditional and/or cardiometabolic factors consistent with metabolic syndrome first year after delivery. The objective this study was to analyze prevalence and persistence contributing for course years pregnancy.In a longitudinally cohort study, 107 formerly were assessed (insulin resistance, obesity, dyslipidemia, hypertension, microalbuminuria)...
( BJOG. 2015;122(8):1092–1100) Preeclampsia (PE) complicates 5% to 8% of all pregnancies and is associated with an increased risk for premature cardiovascular disease (CVD) later in life. Patients a history PE have 2-fold 7-fold developing ischemic cardiac compared healthy controls, depending on gestational age at delivery, about 4-fold chronic hypertension within 15 years after pregnancy. Although it unknown whether itself increases the CVD independently or through factors both CVD,...
Objective. To determine the prevalence of metabolic syndrome in formerly preeclamptic women according to three definitions (World Health Organization [WHO], International Diabetes Federation [IDF], and Third Adult Treatment Panel updated [ATPIII]), evaluate agreement amongst compare risk recurrent preeclampsia.Methods. In 197 with a history preeclampsia, we determined presence using WHO, IDF, ATPIII criteria. We evaluated by Kappa statistics. The preeclampsia was compared between without...
( BJOG . 2015;122(13):1773–1780) Preeclampsia occurs in 2% to 8% of pregnancies and is associated with significant maternal perinatal morbidity mortality. Women a history preeclampsia are at increased risk for subsequent pregnancies. The aim this study was determine the prevalence recurrent women who have been diagnosed metabolic syndrome and/or low plasma volume compared but neither these pathologic conditions.
(Abstracted from Ultrasound Obstet Gynecol 2018;52:196–204) Preeclampsia (PE) is associated with both postpartum endothelial dysfunction and asymptomatic structural heart alterations consistent failure stage B (HF-B). This study assessed the relationship between function, along components of metabolic syndrome, in formerly preeclamptic women healthy parous controls.
Abstract This study aimed to investigate the association between hyperemesis gravidarum (HG) severity and early enteral tube feeding on cardiometabolic markers in offspring cord blood. We included women admitted for HG, who participated MOTHER randomised controlled trial (RCT) observational cohort. The RCT showed that addition standard care did not affect symptoms/birth outcomes. Among cohort participants, we assessed how HG affected lipid, c-peptide, glucose free thyroxine blood levels....