A5017688800- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Cardiac Arrest and Resuscitation
- Infant Development and Preterm Care
- Congenital Anomalies and Fetal Surgery
- Birth, Development, and Health
- Advanced X-ray Imaging Techniques
- Airway Management and Intubation Techniques
- Nuclear Physics and Applications
- Congenital Heart Disease Studies
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Quantum, superfluid, helium dynamics
- Atomic and Subatomic Physics Research
- Ultrasound in Clinical Applications
- Renal and related cancers
- Advanced X-ray and CT Imaging
- Thermal Regulation in Medicine
- Assisted Reproductive Technology and Twin Pregnancy
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
Hudson Institute of Medical Research
2016-2025
Monash University
2016-2025
Intermountain Healthcare
2025
Primary Children's Hospital
2025
Clinical Trial Investigators
2024
Hudson Institute
2011-2023
Monash Institute of Medical Research
2012-2022
Australian Regenerative Medicine Institute
2014-2022
Monash Medical Centre
2013-2020
Japan Synchrotron Radiation Research Institute
2020
Key points Delayed cord clamping improves circulatory stability in preterm infants at birth, but the underlying reason is not known. In a new lamb study we investigated whether delayed until ventilation had been initiated improved pulmonary, cardiovascular and cerebral haemodynamic stability. We demonstrated that prior to markedly function by increasing pulmonary blood flow before clamped, thus further stabilising transition. These results show delaying after onset leads smoother transition...
Aeration of the lung and transition to air-breathing at birth is fundamental mammalian life initiates major changes in cardiopulmonary physiology. However, dynamics this process factors involved are largely unknown, because it has not been possible observe or measure aeration on a breath-by-breath basis. We have used high contrast spatial resolution phase X-ray imaging study spontaneously breathing neonatal rabbits. As liquid-filled fetal lungs provide little absorption contrast, they...
The normal range of heart rate (HR) in the first minutes after birth has not been defined. <h3>Objective</h3> To describe HR changes healthy newborn infants delivery room (DR) detected by pulse oximetry. <h3>Study Design</h3> All inborn were eligible and included if a member research team attended birth. Infants excluded they received any form medical intervention DR including supplemental oxygen, or respiratory support. was measured using oximeter (PO) with sensor applied to right hand...
The factors regulating lung aeration and the initiation of pulmonary gas exchange at birth are largely unknown, particularly in infants born very preterm. As hydrostatic pressure gradients may play a role, we have examined effect positive end-expiratory (PEEP) on spatial temporal pattern preterm rabbit pups mechanically ventilated from using simultaneous phase-contrast X-ray imaging plethysmography. Preterm were delivered by caesarean section 28 days gestational age, anesthetized, intubated,...
Major cardiovascular changes occur at birth, including increased pulmonary blood flow (PBF) and closure of the ductus arteriosus (DA), which acts as a low resistance shunt between fetal systemic circulations. Although pressure gradient these circulations reverses after little is known about DA whether reverse contributes to PBF birth. Our aim was describe in before, during onset ventilation Flow probes were implanted on left artery (LPA) preterm sheep (n = 8) approximately 3 days before they...
Background As measurement of arterial oxygen saturation (SpO2) is common in the delivery room, target SpO2 ranges allow clinicians to titrate therapy for preterm infants order achieve levels similar those seen normal term first minutes life. However, influence onset ventilation and timing cord clamping on systemic cerebral oxygenation not known. Aim We investigated whether initiation ventilation, prior to, or after umbilical clamping, altered lambs. Methods Systemic blood-flows, pressures...
Aims Preterm infants can be inadvertently exposed to high tidal volumes (VT) in the delivery room, causing lung inflammation and injury, but little is known about their effects on brain. The aim of this study was compare an initial 15 min VT resuscitation strategy a less injurious cerebral haemodynamics, injury. Methods lambs at 126 d gestation were surgically instrumented prior receiving with either: 1) High targeting 10–12 mL/kg for first (n = 6) or 2) protective (Prot VT), consisting...
Abstract Phase-contrast X-ray imaging can improve the visibility of weakly absorbing objects (e.g. soft tissues) by an order magnitude or more compared to conventional radiographs. Combining phase retrieval with computed tomography (CT) increase signal-to-noise ratio (SNR) up two orders over CT at same radiation dose, without loss image quality. Our experiments reveal that as dose decreases, relative improvement in SNR increases. We show this enhancement be traded for a reduction greater...
Background Non-invasive ventilation is sometimes unable to provide the respiratory needs of very premature infants in delivery room. While airway obstruction thought be main problem, site unknown. We investigated whether closure larynx and epiglottis a major obstruction. Methods used phase contrast X-ray imaging visualise laryngeal function spontaneously breathing rabbits immediately after birth at approximately 1 hour birth. support was applied via facemask images were analysed determine...
<h3>Background</h3> Delayed umbilical cord clamping (DCC) affects the cardiopulmonary transition and blood volume in neonates immediately after birth. However, little is known of flow vessels birth during DCC. The objective to describe duration patterns through <h3>Methods</h3> Arterial venous was measured DCC using Doppler ultrasound uncomplicated term vaginal deliveries. Immediately birth, probe placed middle cord, pattern vein arteries were evaluated until clamping. <h3>Results</h3>...
Umbilical cord milking (UCM) at birth may benefit preterm infants, but the physiological effects of UCM are unknown. We compared two strategies with immediate umbilical clamping (UCC) and physiological-based (PBCC) in lambs.At 126 days' gestational age, fetal lambs were exteriorised, intubated instrumented to measure umbilical, pulmonary cerebral blood flows arterial pressures. Lambs received either (1) without placental refill (UCMwoPR); (2) (UCMwPR); (3) PBCC, whereby ventilation commenced...