A5091731235- Ovarian cancer diagnosis and treatment
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Phagocytosis and Immune Regulation
- Blood Coagulation and Thrombosis Mechanisms
- Uterine Myomas and Treatments
- Smoking Behavior and Cessation
- Retinopathy of Prematurity Studies
- Tracheal and airway disorders
- Vascular Procedures and Complications
- Tuberous Sclerosis Complex Research
- Air Quality and Health Impacts
- Primary Care and Health Outcomes
- Reproductive tract infections research
- Ethics in Clinical Research
- Genetic Syndromes and Imprinting
Sint Franciscus Gasthuis
2017-2025
Maastricht University
2017-2018
Leiden University Medical Center
1999-2017
Erasmus MC - Sophia Children’s Hospital
1989-2010
Radboud University Nijmegen
2010
IJsselland Ziekenhuis
2010
Radboud University Medical Center
2010
Catharina Ziekenhuis
2008
Erasmus MC
2002-2005
Erasmus University Rotterdam
1990-2005
Purpose To investigate whether initial diagnostic laparoscopy can prevent futile primary cytoreductive surgery (PCS) by identifying patients with advanced-stage ovarian cancer in whom > 1 cm of residual disease will be left after PCS. Patients and Methods This multicenter, randomized controlled trial was undertaken within eight gynecologic centers the Netherlands. suspected who qualified for PCS were eligible. Participating randomly assigned to either or Laparoscopy used guide selection...
Little is known about the development of maximal flow at functional residual capacity, a measure airway patency, in infants with chronic lung disease (CLD). In follow-up study, we evaluated V′maxFRC very low birth weight CLD, treated high-frequency oscillation ventilation (HFOV) or conventional mechanical ventilation. 36 was 6 and/or 12 months corrected age, and relationship between perinatal factors function studied. Mean (SD) gestational age were 837 (152) g 26.8 (1.7) weeks, respectively....
As current literature does not provide sufficient data to support clear guidelines in patients with a rare adult-type granulosa cell tumor, we aim investigate: (1) whether additional staging surgery following primary surgical treatment is necessary; (2) how long standard follow-up should be and (3) risk factors for disease recurrence. A national multicenter prospective study was initiated April 2018. Patients suspected or confirmed tumor were eligible. Data on staging, both retrospectively...
<p>Drug screen response of CTRL+ cell line</p>
<p>IC50 per drug (combination)</p>
<p>Drug screen set-up</p>
<p>Protocol cell culture and drug screen</p>
<div>Abstract<p>In patients with the rare adult-type granulosa cell tumor (aGCT), surgery is primary treatment for both and recurrent disease. In cases of inoperable disease, systematic therapy administered, but variable response rates drug resistance complicate predicting most effective therapy. Drug screen testing on patient-derived lines may offer a solution. national prospective study aGCT, fresh tissue was cultured into 2D lines, 27 clinical experimental drugs. Dose–response...
<p>Growth rate and passage number overview</p>
<p>Drug screen response of several locations per patient</p>
<p>Synergy per drug combination</p>
<p>IC50 related to Cmax</p>
We tested the hypothesis that airway wall dimensions are important determinants for mechanical properties of airways. Lung tissue was obtained from 31 smokers with different degrees chronic obstructive pulmonary disease (COPD) who were operated on a solitary lung lesion. Segments small airways (n = 35) mounted cannulas in an organ bath and inflated deflated cyclically between + 15 − cm H2O. For each this done at baseline, after methacholine, isoprenaline. Specific compliance (sCdyn),...
The role of inhaled corticosteroids in the treatment recurrent or persistent wheeze infancy remains unclear. We evaluated effect 3 months with fluticasone propionate, 200 μg daily (FP200), on lung function and symptom scores wheezy infants. Moreover, we whether infants atopy and/or eczema respond better to FP200 as compared non-atopic Forced expiratory flow (V̇maxFRC) was measured at baseline after treatment. Sixty-five were randomized receive placebo, 62 (mean age, 11.3 months) completed...
Data on 205 children who underwent retrograde arterial catheterisation were studied to assess the frequency of femoral artery thrombosis and safety efficacy systemic streptokinase treatment for this complication. In 29 (14%) a transarterial balloon dilatation was performed. 15 (7.3%) patients impaired perfusion due vascular spasm with or without thrombus formation seen in cannulated leg after catheterisation. Despite heparinisation, signs circulation persisted nine (4.4% total). these...
Abstract Background Cervical cancer is caused by Human Papilloma viruses (HPV) and preceded precursor stages: Intraepithelial Neoplasia (CIN). CIN mostly found in women their reproductive age treated with a Loop Electrosurgical Excision Procedure (LEEP). The recurrence or residual disease rate after treatment up to 17%. These have lifelong increased risk of recurrent CIN, cervical other HPV related malignancies. Furthermore, LEEP treatments are associated complications such as premature...
Abstract Objective Standard surgical treatment of advanced-stage ovarian carcinoma with electrosurgery cannot always result in complete cytoreductive surgery (CRS), especially when many small metastases are found on the mesentery and intestinal surface. We investigated whether adjuvant use a neutral argon plasma device can help increase cytoreduction rate. Patients Methods 327 patients FIGO stage IIIB–IV epithelial cancer (EOC) who underwent primary or interval CRS were randomized to either...
Fractional exhaled nitric oxide concentration (FENO) depends on exhalation flow; however, children often are unable to perform controlled flow procedures. Therefore, a device was developed for off-line FENO sampling, with dynamic restriction (DFR). The authors compared on-line FENO, assessed feasibility, and obtained normal values in aged 4-8 yrs. Subjects inhaled (NO)-free air into the device, where DFR kept constant at 50 mL x s(-1). Dead space discarded. Exhaled collected 150 mylar...
Abstract The cause of lung function abnormalities in bronchopulmonary dysplasia (BPD) is incompletely understood, even the “new era” this disease. Altered airway wall dimensions are important pathogenesis airflow obstruction diseases such as asthma and chronic obstructive pulmonary Whether contribute to BPD unknown. purpose study was investigate relation size BPD. Lung tissue patients with obtained at autopsy, from children who died sudden infant death syndrome (SIDS) served control. Airway...