A5046418852- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Bacterial Infections and Vaccines
- Emergency and Acute Care Studies
- Intensive Care Unit Cognitive Disorders
- Renal function and acid-base balance
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- Family and Patient Care in Intensive Care Units
- Electrolyte and hormonal disorders
- Tracheal and airway disorders
- Palliative Care and End-of-Life Issues
- Infant Development and Preterm Care
- Respiratory viral infections research
- Poisoning and overdose treatments
- Blood Coagulation and Thrombosis Mechanisms
- Streptococcal Infections and Treatments
- Child and Adolescent Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal and Maternal Infections
- Nosocomial Infections in ICU
Hôpital Jeanne de Flandre
2007-2022
Université de Lille
2006-2022
Centre Hospitalier Universitaire de Lille
2009-2022
Evaluation des technologies de santé et des pratiques médicales
2021
Université Lille Nord de France
2010-2014
Université de Montpellier
2014
Lille’s Cardiology Hospital
2004-2013
Hôpital Roger Salengro
2012
Institut du Thorax
2011
Centre Hospitalier Universitaire Sainte-Justine
2010
Multiple organ dysfunction syndrome is the main cause of death in adult ICUs and PICUs. The PEdiatric Logistic Organ Dysfunction score developed 1999 was primarily designed to describe severity dysfunction. This study undertaken update improve score, using a larger more recent dataset.Prospective multicenter cohort study.Nine multidisciplinary, tertiary-care PICUs university-affiliated hospitals France Belgium.All consecutive children admitted these (June 2006-October 2007).None.We collected...
To describe mechanical ventilation strategies in acute lung injury and to estimate the number of eligible patients for clinical trials on management. In contrast adult medicine, there are few guide management children with injury.A cross-sectional study six 24-hr periods from June November 2007.Fifty-nine pediatric intensive care units 12 countries North America Europe.We identified meeting criteria collected detailed information illness severity, ventilatory support, use adjunctive...
To validate procalcitonin (PCT) level as the best biological marker to distinguish between bacterial and aseptic meningitis in children emergency department.Secondary analysis of retrospective multicenter hospital-based cohort studies.Six pediatric or intensive care units tertiary centers 5 European countries.Consecutive aged 29 days 18 years with acute meningitis.Univariate meta-analysis compare performance blood parameters (PCT level, C-reactive protein white cell count, neutrophil count)...
Background. An organ dysfunction (OD) scoring system for critically ill children is not yet available, and the method developing such a well defined. The aim of this study was to compare two developmental methods assessing OD in children. Methods. Consecutive admissions between January May 1997 three French Canadian pediatric intensive care units (PICUs) were studied prospectively. Physiologic data selected using Delphi method; most ab normal values during PICU stay recorded. outcome measure...
The interaction between sepsis and multiple organ dysfunction syndrome is poorly defined in children. We analyzed by Cox regression models the cumulative influence of dysfunctions, using pediatric logistic (PELOD) score, septic state (systemic inflammatory response or sepsis, severe shock) on mortality critically ill included 593 children (mortality rate: 8.6%) from three intensive care units; 514 patients had at least a systemic 269 two more dysfunctions. Hazard ratio death significantly...
We studied the role of viruses and atypical bacteria in children hospitalized with exacerbated asthma by a prospective study acute admitted to Department Pediatrics Lille, 15 hospitals Nord-Pas de Calais region, from October 1, 1998-June 30, 1999. included aged 2-16 years active asthma, defined as three or more recurrent episodes reversible wheezing. The severity asthmatic exacerbations was recorded. Immunofluorescence assays (IFA) on nasopharyngeal secretions (NPS), serological tests, both,...
Abstract Introduction Daily or serial evaluation of multiple organ dysfunction syndrome (MODS) scores may provide useful information. We aimed to validate the daily (d) PELOD-2 score using set seven days proposed with previous version score. Methods In all consecutive patients admitted nine pediatric intensive care units (PICUs) we prospectively measured dPELOD-2 at day 1, 2, 5, 8, 12, 16, and 18. PICU mortality was used as outcome dependent variable. The discriminant power estimated area...
To examine whether physicians or parents assume responsibility for treatment decisions critically ill children and how this relates to subsequent parental experience. A significant controversy has emerged regarding the role of parents, relative physicians, in relation children. Anglo-American settings have adopted decision-making models where are regarded as responsible such life-support decisions, while France commonly considered decision makers.Grounded theory qualitative methodology.Four...
<h3>Background</h3> Clinical decision rules (CDRs) could be helpful to safely distinguish between bacterial and aseptic meningitis (AM). <h3>Objective</h3> To compare the performance of two these CDRs for children: Bacterial Meningitis Score (BMS) Meningitest. <h3>Design</h3> Secondary analysis retrospective multicentre hospital-based cohort study. <h3>Setting</h3> Six paediatric emergency or intensive care units tertiary centres in five European countries. <h3>Patients</h3> Consecutive...
<b>Background:</b> Daily evaluation of multiple organ dysfunction syndrome has been performed in critically ill adults. We evaluated the clinical course over time children using Pediatric Logistic Organ Dysfunction (PELOD) score and determined optimal days for measuring scores. <b>Methods:</b> prospectively measured daily PELOD scores calculated change 1806 consecutive patients admitted to seven pediatric intensive care units (PICUs) between September 1998 February 2000. To study...
To report our 10 year experience with noradrenaline use in children septic shock focusing on doses, routes of administration and complications.Retrospective single-centre review who received between 2000 2010.We identified 144 treated noradrenaline, 22% as the first-line drug. The median volume resuscitation before vasoactive agent was 50 mL/kg interquartile range [IQR: 30-70]. Mean doses ranged from 0.5 ± 0.4 μg/kg per min (starting dose) to 2.5 2.2 (maximum dose). Noradrenaline...
Abstract Introduction The multiple organ dysfunction syndrome (MODS) is a major cause of death for patients admitted to pediatric intensive care units (PICU). Pediatric Logistic Organ Dysfunction (PELOD) score has been validated in order describe and quantify the severity (OD). There are several physiological differences between neonates older children. objective study was determine whether there incidence ODs mortality rate full-term (age <28 days) Methods In prospective, observational...
Septic shock is frequent in children and associated with high mortality morbidity rates. Early recognition of severe sepsis improve outcome. Shock index (SI), ratio heart rate (HR) systolic blood pressure (SBP), may be a good noninvasive measure hemodynamic instability that has been poorly studied children. The aim the study was to explore usefulness SI as an early prognosis for septic children.The retrospective performed 1 pediatric intensive care unit at university hospital. following...
Cardiogenic shock which corresponds to an acute state of circulatory failure due impairment myocardial contractility is a very rare disease in children, even more than adults. To date, no international recommendations regarding its management critically ill children are available. An experts' adult population have recently been made (Levy et al. Ann Intensive Care 5(1):52, 2015; Levy 5(1):26, 2015). We present herein for the cardiogenic developed with grading recommendations' assessment,...
The common paediatric critical care practice in France is for physicians (rather than parents) to maintain the ultimate responsibility lifesupport decisions children. Some French literature asserts that it inappropriate parents bear such responsibilities because they do not have required knowledge and should be protected from feeling culpable decisions. aim of this grounded theory preliminary study was examine moral experience critically-ill children life-support France. A convenience...
Objective: To estimate the prevalence of chronic conditions and/or disability in intensive care units admitting children (Pediatric Intensive Care Unit [PICU]) or both neonates and (Neonatal Pediatric [NPICU]) to describe available rehabilitation resources. Design: A cross-sectional study on two separate days, using a web questionnaire. Setting: NPICU/PICUs affiliated Groupe Francophone de Réanimation et Urgences Pédiatriques Réseau Mère-Enfant la Francophonie. Patients: Children >1 month...