A5045584319- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Pediatric Urology and Nephrology Studies
- Sepsis Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Emergency and Acute Care Studies
- Urinary Tract Infections Management
- Cardiac Arrest and Resuscitation
- Vector-borne infectious diseases
- Neonatal and Maternal Infections
- Thermal Regulation in Medicine
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Neonatal Respiratory Health Research
- HIV Research and Treatment
- Viral Infections and Vectors
- Pharmaceutical studies and practices
- Bacterial Identification and Susceptibility Testing
- Child and Adolescent Health
- Parvovirus B19 Infection Studies
- Infective Endocarditis Diagnosis and Management
- Zoonotic diseases and public health
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
University of Geneva
2015-2025
University Hospital of Geneva
2015-2024
HES-SO University of Applied Sciences and Arts Western Switzerland
2022
Geneva College
2004-2021
Pediatrics and Genetics
2019
Hôpital des Enfants
2005-2018
Boston Children's Hospital
2003-2014
Emergency University
2014
Hôpital de l'enfance
2001-2011
Hôpital Beau-Séjour
1988-2010
BACKGROUND: A sequential approach to young febrile infants on the basis of clinical and laboratory parameters, including procalcitonin, was recently described as an accurate tool in identifying patients at risk for invasive bacterial infection (IBI). Our aim prospectively validate Step-by-Step compare it with Rochester criteria Lab-score. METHODS: Prospective study ≤90 days fever without source presenting 11 European pediatric emergency departments between September 2012 August 2014. The...
Determination of HIV infectivity in vitro and its inhibition by antiretroviral drugs monitoring reduction production p24 antigen is expensive time consuming. Such assays also do not allow accurate quantitation the number infected cells over time. To develop a simple, rapid, direct method for infection, we generated stable T-cell line (CEM) containing plasmid encoding green fluorescent protein (humanized S65T GFP) driven HIV-1 long terminal repeat. Clones were selected that displayed low...
Objective. To assess the value of bedside tests for predicting occurrence severe bacterial infections (SBIs) in children with fever without source. Methods. We conducted a prospective study 99 children, aged 7 days to 36 months, who were seen >38°C and no localizing sign infection at emergency department University Children’s Hospital Geneva. Blood procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6) values determined using rapid compared total white blood cell (WBC)...
To validate procalcitonin (PCT) level as the best biological marker to distinguish between bacterial and aseptic meningitis in children emergency department.Secondary analysis of retrospective multicenter hospital-based cohort studies.Six pediatric or intensive care units tertiary centers 5 European countries.Consecutive aged 29 days 18 years with acute meningitis.Univariate meta-analysis compare performance blood parameters (PCT level, C-reactive protein white cell count, neutrophil count)...
Background The management of childhood infections remains inadequate in resource-limited countries, resulting high mortality and irrational use antimicrobials. Current disease tools, such as the Integrated Management Childhood Illness (IMCI) algorithm, rely solely on clinical signs have not made available point-of-care tests (POCTs) that can help to identify children with severe need antibiotic treatment. e-POCT is a novel electronic algorithm based current evidence; it guides clinicians...
BACKGROUND: Reliably distinguishing bacterial from viral infections is often challenging, leading to antibiotic misuse. A novel assay that integrates measurements of blood-borne host-proteins (tumor necrosis factor-related apoptosis-inducing ligand, interferon γ-induced protein-10, and C-reactive protein [CRP]) was developed assist in differentiation between disease. METHODS: We performed double-blind, multicenter evaluation using serum remnants collected at 5 pediatric emergency departments...
ABSTRACT Originally composed of the single family Chlamydiaceae , Chlamydiales order has extended considerably over last several decades. Chlamydia -related bacteria were added and classified into six different families family-level lineages: Criblamydiaceae Parachlamydiaceae Piscichlamydiaceae Rhabdochlamydiaceae Simkaniaceae Waddliaceae . While members are known pathogens, recent studies showed diverse associations with human animal infections. Some these latter might be medical importance...
ABSTRACT Our study is the first to compare nasopharyngeal microbiota of pediatric pneumonia patients and control children by 454 pyrosequencing. A distinct was associated with different etiologies. Viral a high abundance operational taxonomic unit (OTU) corresponding Moraxella lacunata . Patients nonviral showed abundances OTUs three typical bacterial pathogens, Streptococcus pneumoniae complex, Haemophilus influenzae catarrhalis classified as having no definitive etiology harbored...
<h3>Objectives</h3> To compare the diagnostic properties of procalcitonin (PCT), C reactive protein (CRP), total white blood cells count (WBC), absolute neutrophil (ANC) and clinical evaluation to detect serious bacterial infection (SBI) in children with fever without source. <h3>Design</h3> Prospective cohort study. <h3>Setting</h3> Paediatric emergency department a tertiary care hospital. <h3>Participants</h3> Children aged 1–36 months no identified source infection. <h3>Intervention</h3>...
BackgroundNoma is a poorly studied disease that leads to severe facial tissue destruction in children developing countries, but the cause remains unknown. We aimed identify epidemiological and microbiological risk factors associated with noma disease.MethodsWe did prospective, matched, case-control study Niger between Aug 1, 2001, Oct 31, 2006, younger than 12 years assess for acute noma. All cases were included four controls each case matched by age home village. Epidemiological clinical...
C-reactive protein (CRP) and procalcitonin (PCT) are useful diagnostic tools to estimate the risk of serious bacterial infection (SBI) in febrile children at emergency department (ED). The Lab-score combines these 2 biomarkers with urinalysis an easy use validated model. Kinetics inflammatory markers suggests a differentiating role duration disease.: Appraisal CRP PCT SBI, determining value fever, validating updating Lab-score.In this prospective observational study previously healthy 1...
Background: The American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) are nowadays recognized as the world's most authoritative guidelines. Adherence to these optimizes management of critically ill patients and increases their chances survival after cardiac arrest. Despite availability, suboptimal quality CPR is still common. Currently, median hospital rate pediatric in-hospital arrest 36%, whereas it falls below 10% out-of-hospital Among emerging information...
Procedural sedation and analgesia outside the operating theater have become standard care in managing pain anxiety children undergoing diagnostic therapeutic procedures. The objectives of this study are to describe current pediatric procedural practice patterns European emergency departments, perform a needs assessment-like analysis, identify barriers implementation. A survey departments treating was conducted. Through lead research coordinator identified through Research Pediatric Emergency...
The interpretation of lung auscultation is highly subjective and relies on non-specific nomenclature. Computer-aided analysis has the potential to better standardize automate evaluation. We used 35.9 hours audio from 572 pediatric outpatients develop DeepBreath : a deep learning model identifying audible signatures acute respiratory illness in children. It comprises convolutional neural network followed by logistic regression classifier, aggregating estimates recordings eight thoracic sites...
Background. Urinary tract infection (UTI) is a common problem in children. Because clinical findings and commonly used blood indices are nonspecific, the distinction between lower upper urinary cannot be made easily this population. However, important because renal can induce parenchymal scarring. The objective of study was to determine accuracy procalcitonin (PCT) compared with C-reactive protein (CRP) rapid tests predict involvement children febrile UTI. Methods. PCT CRP were measured...
The objective of the study was to develop a simple clinical tool identify serious bacterial infection (SBI) in children with fever without source. For each child, assessment, white blood cell count, urine analysis, determination C-reactive protein, procalcitonin, and appropriate cultures were performed. Two hundred two studied whom 54 (27%) had SBI. In multivariate only procalcitonin [odds ratio (OR): 37.6], protein (OR: 7.8), dipstick 23.2) remained significantly associated sensitivity...
<h3>Background</h3> Clinical decision rules (CDRs) could be helpful to safely distinguish between bacterial and aseptic meningitis (AM). <h3>Objective</h3> To compare the performance of two these CDRs for children: Bacterial Meningitis Score (BMS) Meningitest. <h3>Design</h3> Secondary analysis retrospective multicentre hospital-based cohort study. <h3>Setting</h3> Six paediatric emergency or intensive care units tertiary centres in five European countries. <h3>Patients</h3> Consecutive...
<h3>Objective</h3> The identification of severe bacterial infection (SBI)in children with fever without source (FWS) remains a diagnostic problem. authors previously developed in their Swiss population risk index score, called the Lab-score, associating three independent predictors SBI, namely C reactive protein (CRP), procalcitonin (PCT) and urinary dipstick. objective this study was to validate Lab-score FWS different from derivation model. <h3>Methods</h3> A prospective study, conducted...