A5003562223- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Myasthenia Gravis and Thymoma
- Renal Transplantation Outcomes and Treatments
- Vascular Anomalies and Treatments
- Trauma Management and Diagnosis
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Occupational and environmental lung diseases
- Musculoskeletal pain and rehabilitation
- Opioid Use Disorder Treatment
University Health Network
2014-2025
University of Toronto
2011-2023
Toronto General Hospital
2014-2023
Innovative Research Group (Canada)
2022
McGill University Health Centre
2017
Montreal General Hospital
2017
Princess Margaret Cancer Centre
2002-2016
Toronto Public Health
2002-2016
McMaster University
2001-2010
St. Joseph’s Healthcare Hamilton
2010
Chronic postsurgical pain (CPSP), an often unanticipated result of necessary and even life-saving procedures, develops in 5-10% patients one-year after major surgery. Substantial advances have been made identifying at elevated risk developing CPSP based on perioperative pain, opioid use, negative affect, including depression, anxiety, catastrophizing, posttraumatic stress disorder-like symptoms. The Transitional Pain Service (TPS) Toronto General Hospital (TGH) is the first to...
Cytokines have been shown to play an important role in promoting inflammation the setting of ischemia-reperfusion injury. However, their human lung transplantation has not systematically explored. This study was undertaken examine kinetics cytokine release 18 consecutive procedures and relationships between levels donor factors, length ischemic time, allograft function. TNF-alpha, IFN-gamma, IL-10, IL-12, IL-18 were found at higher during whereas IL-8 predominantly increased after...
There is no consensus on the best technique for lung isolation thoracic surgery. In this study, we compared clinical performance of three bronchial blockers (BBs) available in North America with left-sided double-lumen tubes (DLTs) patients undergoing surgery.One hundred four thoracotomy or video-assisted thoracoscopic surgery were randomly assigned to one groups (n = 26/group). Lung was an Arndt wire-guided BB (Cook Critical Care, Bloomington, IN), a Cohen Flexi-tip Care) Fuji Uni-blocker...
Inhalation of nitric oxide (NO) has been advocated as a method to prevent ischemia–reperfusion injury after lung transplantation. We enrolled 84 patients into concealed, randomized, placebo-controlled trial evaluate the effect inhaled NO (20 ppm or nitrogen) initiated 10 minutes reperfusion on outcomes The groups (n = 42) were balanced with respect age, sex, disease, procedure, and total ischemic times. PaO2/FIO2 ratios similar admission intensive care unit (ICU) (NO 361 ± 134; control 357...
Background Positive end-expiratory pressure (PEEP) is commonly applied to the ventilated lung try improve oxygenation during one-lung ventilation but an unreliable therapy and occasionally causes arterial oxygen partial (PaO(2)) decrease further. The current study examined whether effects of PEEP on depend static compliance curve which it applied. Methods Forty-two adults undergoing thoracic surgery were studied stable, open-chest, ventilation. Arterial blood gases measured two-lung before,...
Double-lumen endobronchial tubes are the most common method of achieving lung isolation and one-lung ventilation during thoracic anaesthesia surgery. We compared clinical performance Macintosh laryngoscope GlideScope(®) intubation with a double-lumen tube. Seventy patients no predictors for difficult laryngoscopy were allocated randomly to or GlideScope. The time taken was significantly shorter that GlideScope, median (IQR [range]) 33 (22-52 [11-438]) s vs 70 (39-129 [21-242]) s,...
ABSTRACT Background The perioperative period provides a critical window to address opioid use, particularly in patients with history of chronic pain and presurgical use. Toronto General Hospital Transitional Pain Service (TPS) was developed the issues use after surgery. Aims To provide program evaluation results from TPS at highlighting weaning rates management opioid-naïve opioid-experienced surgical patients. Methods Two hundred fifty-one high-risk were dichotomized preoperatively as naïve...
Little is known about the factors that predict transition of acute, time limited pain to chronic pathological following postero-lateral thoracotomy. The aim present prospective, longitudinal study was determine extent which (1) pre-operative intensity, disability, and post-traumatic stress symptoms (PTSS) post-thoracotomy disability 6 12 months later; (2) if these variables, assessed at months, month disability. Fifty-four patients scheduled undergo thoracotomy for intrathoracic malignancies...
Diaphragm inactivity during invasive mechanical ventilation may predispose the lung and diaphragm to injury, is associated with adverse clinical outcomes. Assess feasibility of continuous on-demand neurostimulation-assisted maintain activity in absence respiratory drive for at least 24 hours ventilation. In a single center phase 1 trial, patients receiving acute hypoxemic failure or after thoracic surgery underwent transvenous neurostimulation delivered synchrony was when breaths were...
Objective: To study the impact of minimally invasive trans-cervical thymectomy on incidence remission patients with myasthenia gravis (MG) in a single institution over 10-year period. Methods: A total 120 consecutive referred for video-assisted between 1991 and 2000 were included analysis. Complete was defined as no symptoms treatment 6 months, minimal ocular (slight ptosis) or pyridostigmine only months. Results: There 86 females 34 males median age 33 (range 14–79) 36 years 12–68),...
In Brief BACKGROUND: Collapse of the ipsilateral lung facilitates surgical exposure during thoracic procedures. The use different gas mixtures two-lung ventilation (2LV) may improve or impede conditions subsequent one-lung (OLV) by increasing delaying collapse. We investigated effects three 2LV on collapse and oxygenation OLV: Air/Oxygen (fraction inspired oxygen [Fio2] = 0.4), Nitrous Oxide/Oxygen ("N2O," Fio2 0.4) Oxygen ("O2," 1.0). METHODS: Subjects were randomized into groups: (n 33),...
Background Lung growth in children is associated with dramatic increases the number and surface area of alveolated airways. Modelling studies have shown slope alveolar plateau (phase III) sensitive to total cross-sectional these Therefore, influence age body size on phase III volumetric capnogram was investigated. Methods Phase (alveolar dcCO2/dv) airway deadspace (VDaw) were derived from repeated single-breath carbon dioxide expirograms collected 44 healthy mechanically ventilated (aged 5...