A5069934491- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- vaccines and immunoinformatics approaches
- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Nanoparticle-Based Drug Delivery
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Cancer Research and Treatments
- Antimicrobial Peptides and Activities
Nanjing Medical University
2025
Huazhong University of Science and Technology
2019-2023
Union Hospital
2019-2023
First Hospital of China Medical University
2019
Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy immunotherapy unknown. Here we show the length of time deprivation affects tumoral ferroptosis differently. Prolonged prevents glutathione (GSH) depletion from exceeding death threshold by blocking cation transport regulator homolog 1 (CHAC1) protein synthesis. Whereas, short-term starvation accelerates stimulating CHAC1...
Abstract Intratumoral heterogeneity, including epithelial–mesenchymal transition (EMT), is one major cause of therapeutic resistance. The induction ferroptosis, an iron‐dependent death, has the potential in overcoming this resistance to traditional treatment modalities. However, roles distinct EMT phenotypes ferroptosis remain enigma. This study reports that 3D soft fibrin microenvironment confers colorectal cancer (CRC) cells hybrid phenotype and high level ferroptosis. activation histone...
Autologous tumor cells and cell-derived secretions (CDS) can induce antitumor immune responses. The conditions in which are cultured treated impact CDS, cellular insults alter their composition function. In this study, we generated CDS from exposed to normal culture conditions, hypoxia, cisplatin, radiotherapy, photodynamic therapy, or hypochlorous acid (HOCl). vitro HOCl-CDS showed the strongest stimulatory effects on dendritic macrophages compared by radiotherapy therapy. To improve...
Simple mixing of ICG with DOTAP liposomes results in full dye binding to the and enhanced optical properties.
The fabrication of MCL and the mechanism MCL-mediated antitumor effects against melanoma.
e21587 Background: Immunotherapies targeting immune checkpoint receptors have become the cornerstone of systemic treatment options for malignant melanoma. The response to these immunotherapies may correlate with driver mutations. MAP2K1/2 genes are mutated in approximately 10% melanomas, however, impact gene alterations on efficiency immunotherapy has not been clarified. Methods: Six metastatic melanoma clinical cohorts treated ICIs were included investigate association between efficacy and...
目的 根据胃大部分切除患者的临床特征，实施健康教育联合心理干预，观察其应用效果。 方法 从2017年11月至2018年8月中国医科大学附属第一医院收治的患者中随机抽取68例作为研究对象，按照其就诊的先后顺序将其分为研究组(36例)和对照组(32例)。对照组患者给予常规护理，研究组患者采取健康教育联合心理干预。将两组患者的焦虑抑郁评分、生存质量评分、治疗依从性、护理满意度等情况进行比较、分析。 结果 护理前，两组患者的焦虑抑郁评分差异无统计学意义；护理后，研究组患者的焦虑评分[(29.33±4.13)分]、抑郁评分[(31.04±4.11)分]明显较低，研究组患者的生存质量评分、治疗依从性(91.67%)以及护理满意度(94.44%)均明显高于对照组，差异均有统计学意义(t＝23.893、16.943，χ2＝9.817、10.578，均P<0.05)。 结论 对胃大部分切除的胃癌患者实施健康教育联合心理干预，可以有效缓解患者的不良情绪反应，提高患者的治疗依从性和满意度。
Leong-Zohr, S P L; Enders-Zohr, P; Zhou, Y M; Alten, R E Jr.; Sagebiel, W; Glassberg, A B; Hayes, F Author Information