Kai Zhang

ORCID: 0000-0002-3604-6591
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About
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Research Areas
  • Ginseng Biological Effects and Applications
  • Pharmacological Effects of Natural Compounds
  • Gut microbiota and health
  • Tumors and Oncological Cases
  • Extracellular vesicles in disease
  • Teratomas and Epidermoid Cysts
  • Multiple and Secondary Primary Cancers
  • Gastrointestinal disorders and treatments
  • Head and Neck Surgical Oncology
  • MicroRNA in disease regulation
  • Inflammatory Bowel Disease
  • Natural product bioactivities and synthesis
  • Oral and Maxillofacial Pathology
  • Gastric Cancer Management and Outcomes
  • Cancer-related molecular mechanisms research
  • Advanced biosensing and bioanalysis techniques
  • Ferroptosis and cancer prognosis
  • IgG4-Related and Inflammatory Diseases
  • Burn Injury Management and Outcomes
  • GDF15 and Related Biomarkers
  • Plasma Applications and Diagnostics
  • Tea Polyphenols and Effects
  • Virus-based gene therapy research
  • Soft tissue tumor case studies
  • IL-33, ST2, and ILC Pathways

China Medical University
2025

Second Affiliated Hospital of Jilin University
2016-2024

Jilin University
2018-2024

Shanghai University of Traditional Chinese Medicine
2018

Intestinal inflammatory imbalance and immune dysfunction may lead to a spectrum of intestinal diseases, such as bowel disease (IBD) gastrointestinal tumors. As the king herbs, ginseng has exerted wide range pharmacological effects in various diseases. Especially, it been shown that ginsenosides have strong immunomodulatory anti-inflammatory abilities system. In this review, we summarized how extracts influence inflammation function, including regulating balance, modulating expression...

10.3389/fimmu.2024.1353614 article EN cc-by Frontiers in Immunology 2024-04-18

Peritoneal adhesion is a complex fibrosis and inflammatory process, it can be minimized by physical isolation biomaterial membranes or treatment with cytostatic and/or anti-inflammatory drugs. However, the integration of pharmaceutical therapy in one platform faces many challenges. First, normal polymer antiadhesion are hydrophobic show low bioadhesion to injured tissue, which decrease their efficacies. Second, significantly different release behaviors various drugs owing...

10.1021/acsbiomaterials.7b00605 article EN ACS Biomaterials Science & Engineering 2017-09-07

Background About 89% of global End-stage renal disease (ESRD) patients receive hemodialysis. Data show that about 40% ~ 60% dialysis are young and middle-aged. Hemodialysis significantly impacts the daily life rehabilitation patients, underscoring urgency understanding their experiences needs. However, findings from previous individual qualitative studies may lack representativeness. Aims This study used Meta-synthesis to offer a thorough lived experiences, psychological states, needs...

10.3389/fmed.2025.1530465 article EN cc-by Frontiers in Medicine 2025-04-07

Abstract BACKGROUND Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory with severe diarrhea, fatigue and weight loss. α‐Lipoic acid (LA), well‐known antioxidant, able to scavenge reactive oxygen species (ROS) maintain healthy cellular redox state. However, the role of LA in protecting IBD still unclear. Hence aim this research was investigate protective effect on dextran sulfate sodium salt ‐induced ulcerative colitis (UC) its underlying mechanism. RESULTS Here, our...

10.1002/jsfa.13053 article EN Journal of the Science of Food and Agriculture 2023-10-18

Intense efforts have been made in colorectal cancer (CRC) treatment recent decades. However, the mechanism of development and metastasis CRC has not fully cleared. This study is designed to identify key proteins involved stage III hepatic metastatic CRC.Protein expression profiles paired tumor benign tissue samples from patients are characterized by using a label-free proteomics approach. Key relevant revealed weighted gene correlation network analysis (WGCNA) other bioinformatics...

10.1002/prca.201900017 article EN PROTEOMICS - CLINICAL APPLICATIONS 2019-08-09

Abstract Background Tailgut cysts arise from the remnants of tailgut during embryonic period. Although malignant transition is very rarely observed in clinic, this congenital condition should be carefully monitored for early diagnosis and appropriate treatment, especially when are malignant. Case presentation Here, we report case a 33-year-old man with retrorectal adenocarcinoma originating cysts. Magnetic resonance imaging (MRI) showed many cystic masses posterior rectal space, largest...

10.1186/s12893-019-0639-9 article EN cc-by BMC Surgery 2019-11-27

Ectopic pancreas, which is a kind of rare congenital disease, forms during embryonic development. It can occur throughout the whole gastrointestinal tract, but has low tendency to develop in wall small intestine. easy for patients with ectopic pancreases be misdiagnosed because symptoms are untypical and vary.In present study, we reported two cases pancreatic tissue intestine, presented obvious abdominal pain distention.The laboratory tests computed tomography (CT) scans didn't reveal any...

10.1097/md.0000000000007986 article EN cc-by-nc Medicine 2017-08-29

Rationale: Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis, which rarely associated with pseudocyst. Patient concerns: A 48-year-old man complained recurrent upper abdominal pain in our hospital. Diagnoses: cystic mass size 4 × 3 cm his pancreatic tail was found by computed tomography. The concentrations serum carbohydrate antigen19–9 (81 U/mL) and immunoglobulin G4 (181 mg/dL) were elevated. Interventions: patient received partial pancreatectomy splenectomy...

10.1097/md.0000000000010439 article EN Medicine 2018-05-01

The aim of this article is to evaluate and compare the postprocedure pain in patients with pancreatic carcinoma treated irreversible electroporation (IRE) cryoablation (CRYO). We compared 22 lesions pancreas IRE 26 27 cryosurgery. All two groups were under celiac plexus block (CPB) treatment alleviate pain. A numerical rating scale (VAS) consisting 11-point scales 24 h total hydromorphone use recorded for analysis level who underwent these technologies separately. Other parameters, such as...

10.1155/2016/2543026 article EN cc-by BioMed Research International 2016-01-01

Abstract Rationale: Tailgut cysts are a type of very rare congenital polycystic lesions that always located posterior to the rectum and anterior sacrum. The symptoms tailgut nonspecific misleading. Therefore, full understanding characteristics is important for their diagnosis treatment. Patient concerns: We report 46-year-old female with sacrococcygeal mass had been present about 2 years. Diagnoses: Pelvic magnetic resonance imaging (MRI) indicated several cystic masses, largest which...

10.1097/md.0000000000014448 article EN cc-by-nc Medicine 2019-02-01

Gastric cancer is among the most common malignant tumors of digestive tract. Establishing a robust and reliable animal model foundation for studying pathogenesis cancer. The present study established mouse gastric carcinoma by inoculating immunocompetent mice with MKN45 cells using microcarrier. Sixty male C57BL/6 were randomly divided into three groups: 2D group, an empty carrier 3D according to coculture system models hypodermic injection. Time develop tumor, rate tumor formation,...

10.1155/2020/1893434 article EN cc-by BioMed Research International 2020-04-06
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