A5024995861- Kantian Philosophy and Modern Interpretations
- Philosophical Ethics and Theory
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Genomics and Chromatin Dynamics
- Pharmacogenetics and Drug Metabolism
- Geotechnical Engineering and Soil Stabilization
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Psychoanalysis and Social Critique
- Polyamine Metabolism and Applications
- Engineering Applied Research
- Antimicrobial Peptides and Activities
- Mast cells and histamine
- Cancer Research and Treatments
- Agriculture, Soil, Plant Science
- Geotechnical Engineering and Soil Mechanics
- Religion, Theology, and Education
- Geotechnical Engineering and Underground Structures
- Scientific Research and Philosophical Inquiry
- Neuroethics, Human Enhancement, Biomedical Innovations
- Circular RNAs in diseases
- PI3K/AKT/mTOR signaling in cancer
- Epistemology, Ethics, and Metaphysics
- Ferroptosis and cancer prognosis
Korean Drug Co.
2023-2025
Korea Pharma (South Korea)
2025
Soonchunhyang University
2017-2022
Chung-Ang University
2021
Abstract Melatonin suppresses tumor development. However, the exact relationship between melatonin and cancer stem cells ( CSC s) is poorly understood. This study found that inhibits colon s by regulating Pr P C ‐Oct4 axis. In specimens from patients with colorectal cancer, expressions of cellular prion protein (Pr ) Oct4 were significantly correlated metastasis stages. Co‐treatment 5‐fluorouracil (5‐ FU inhibited cell markers Oct4, Nanog, Sox2, ALDH 1A1 downregulating . this way, growth,...
Globally, the mortality rate of colorectal cancer (CRC) remains high. Despite development various treatments, such as targeted therapy and immunotherapy, continues to be a serious health issue worldwide. Identifying new biomarkers is essential for improving prognosis tailoring therapies CRC. This study aims elucidate role CYP4X1 in CRC its association with patient survival clinicopathological parameters. Using TCGA databases like GENT2, UALCAN, GEPIA, we analyzed expression normal tissues....
HJURP is a key factor for CENP-A deposition and maintenance in centromeres. The role of mis-regulation histone chaperones cancer initiation progression has been studied. However, its colorectal still unclear. In this study, we aimed to evaluate the expression 162 tissue. To investigate function cell, suppressed by siRNA confirmed proliferation, migration, invasion, anchorage independent colony forming ability. association between levels clinicopathological factors was evaluated CRC tissues...
Although major driver gene mutations have been identified, the complex molecular heterogeneity of colorectal cancer (CRC) remains unclear. Capicua (CIC) functions as a tumor suppressor in various types cancers; however, its role CRC progression has not examined.Databases for expression profile patient samples were used to evaluate association levels CIC and Polyoma enhancer activator 3 (PEA3) group genes (ETS translocation variant 1 (ETV1), ETV4, ETV5), best-characterized targets terms...
Uncovering tumor markers of colorectal cancer is important for the early detection and prognosis patients. Spermine oxidase (SMOX) upregulated in various cancers. The present study aims to explore biologic function expression patterns SMOX (CRC), third most common type worldwide. We used quantitative real-time PCR, Western blot, vitro functional studies four CRC cell lines knocked down by siRNA immunohistochemistry 350 cases tissues. results showed that was overexpressed clinical samples....
Defensin alpha 6 (DEFA6) is a member of the defensin family microbicidal and cytotoxic peptides that defend against bacteria viruses. Here, we provide novel function DEFA6 in tumorigenesis colorectal cancer (CRC) vitro vivo. Specifically, highly expressed both CRC cell lines as well patient-derived samples at level RNA protein. By shRNA-mediated loss DEFA6, found proliferation, migration, invasion, colony forming ability were impaired absence vitro. Furthermore, DEFA6-deficient cells...
Abstract Background Colorectal cancer (CRC) is the third most common and has second highest mortality rate. The recurrence rate of colorectal 30–50%, survival patients with metastasis very low. Prognostic biomarkers can be guidelines for therapeutic management patients. cytochrome P450 (CYP) family upregulated in various cancers contributes to cell proliferation, signaling drug metabolism. In addition, Cytochrome related xenobiotics endogenous compounds. Nevertheless, role CYP4X1 regulating...
This study attempts to develop theoretical criteria for verifying the morality of actions artificial intelligent agents, using Turing test as an archetype and inspiration.This develops ethical established based on Kohlberg's moral development theory that might help determine types acts committed by agents.Subsequently, it leverages these in a experiment with Korean children aged around ten years.The concludes 10-year-old participants' stage falls between first second tests.We evaluate...
There is a wide variety of discussions about the definition happiness, attitudes and methods to pursue it. However, as lecturer progressed through ‘creativity communication’ subjects, many students are indeed very interested in but their understanding happiness simple dichotomous. This dichotomous view can be hindrance sincere realistic attitude life. Therefore, presenting another viewpoint positive point that this subject set. In paper, first, I present antinomic hapiness college case...
In his famous essay from 1784, Kant denied that we "live in an enlightened age"; yet he claimed age of enlightenment". If should answer the question if live now, could basically give same answer. The enlightenment as ongoing process can be found throughout Kant's whole work. This article focuses on how concept applied to Kantian psychology, which marks important change theory soul within modern western metaphysics. idea and 'critique' will illustrated with reference "Paralogisms" Critique...
이 글은 구성주의적 정보 철학의 관점에서 ‘주체’의 개념사 구성을 시도해 보고 그 구성요소에 대한 평가를 내림으로써 특성의 한 면을 간접적으로 구체화하는 것을 목표로 한다. 구성주의의 핵심은 모든 지식은 구성적이라는 것으로 배경에는 세계 내 경험적 존재자는 주관적 그가 경험한 사태를 구성하여 지식화, 정보화한다는 전제가 놓여있다. 한편 철학은 자체의 의미와 이와 관련된 원리와 개념에 메타적인 분석과 설명을 제시하는 것이라 할 수 있다. 이러한 이해 위에서 박충식은 구성적 철학(2018)이라는 개념을 만들어 이를 관점의 철학으로 정의한다. 정보철학으로 고쳐 기술할 것이다. 이론에 따르면 자기 생산적 정보처리체계는 그것이 놓여진 환경에서 자신의 존재를 지속하기 위해 정보를 구성하는 기능적인 계산 모델이다. 철학 관점에서는 보면 철학적 개념으로서의 ‘주체’는 단순히 만들어진 불과하다. 데카르트부터 루만에 이르는 서양 지성사의 주체 구성해 보고, 각 장면을 이론을 평가한다.