A5055736621- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Optical Imaging and Spectroscopy Techniques
- Thermography and Photoacoustic Techniques
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Maternal and fetal healthcare
- Photodynamic Therapy Research Studies
- Liver Disease and Transplantation
- Hemodynamic Monitoring and Therapy
- Cancer Risks and Factors
- Cerebrovascular and Carotid Artery Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Prenatal Screening and Diagnostics
- Ectopic Pregnancy Diagnosis and Management
- Optical Coherence Tomography Applications
- Laser-induced spectroscopy and plasma
- Ovarian cancer diagnosis and treatment
- Electrical and Bioimpedance Tomography
- Cardiovascular Issues in Pregnancy
- Infrared Thermography in Medicine
- Advanced Biosensing Techniques and Applications
- Laser Material Processing Techniques
- Ocular and Laser Science Research
Canon (United States)
2018-2023
Varian Medical Systems (United States)
2018-2023
Northeast Ohio Medical University
2023
University of Atlanta
2023
University of South Carolina
2023
Thomas Jefferson University
2023
Texas Children's Hospital
2023
Baylor College of Medicine
2023
University of Alabama at Birmingham
2023
University of Southern California
2023
Using a hand-held photoacoustic probe integrated with clinical ultrasound array system, we successfully imaged objects deeply positioned in biological tissues. The optical contrasts were enhanced by methylene blue concentration of ~30 mM. penetration depth reached ~5.2 cm chicken breast tissue using 650-nm wavelength, which is ~4.7 times the 1/e depth. This imaging was achieved laser fluence on surface only 3 mJ/cm(2), 1/7 American National Standards Institute (ANSI) safety limit (20...
Abstract The detection of regional lymph node metastases is important in cancer staging as it guides the prognosis patient and strategy for treatment. Sentinel biopsy (SLNB) an accurate, less invasive alternative to axillary dissection. sentinel hypothesis states that pathological status axilla can be accurately predicted by determining first nodes drain from primary tumor. Physicians use radio-labeled sulfur colloid and/or methylene blue dye identify SLN, which most likely contain...
To evaluate in vivo sentinel lymph node (SLN) mapping by using photoacoustic and ultrasonographic (US) imaging with a modified clinical US system.Animal protocols were approved the Animal Studies Committee. Methylene blue dye accumulation axillary nodes of seven healthy Sprague-Dawley rats was imaged system adapted from system. investigate translation, depth extended up to 2.5 cm adding chicken or turkey breast on top rat skin surface. Three-dimensional images acquired mechanically scanning...
By modifying a clinical ultrasound array system, we develop novel handheld photoacoustic probe for image-guided needle biopsy. The integration of optical fiber bundles pulsed laser light delivery enables insertion into rat axillary lymph nodes with accumulated indocyanine green (ICG). Strong contrast the is achieved. After subcutaneous injection dye in left forepaw, sentinel are easily detected, vivo and real time, beneath 2-cm-thick chicken breast overlaying region. ICG uptake confirmed...
The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy absorption spectroscopy. PA signal is proportional to product optical coefficient local light fluence; quantitative measurements therefore require an accurate estimation fluence. Light-modeling aided by diffuse tomography (DOT) can be used map required fluence reduce errors in traditional spectroscopic analysis. As a proof-of-concept, we designed tissue-mimicking phantom demonstrate how...
Clinical translation of photoacoustic (PA) imaging can be facilitated by integration with commercial ultrasound (US) scanners to enable dual-modality imaging. An array-based US scanner was modified for hand-held PA The performance benchmarked in terms signal-to-noise ratio (SNR), axial spatial resolution and sensitivity. images a tube, filled methylene blue (MB; approx. 30 mM) placed at various depths chicken tissue, were acquired. A 5 cm penetration depth achieved an 18.6 dB SNR using laser...
Objectives: The use of antiangiogenic therapy in conjunction with traditional chemotherapy is becoming increasingly cancer management, but the optimal benefit these targeted pharmaceuticals has been limited to a subset population treated. Improved imaging probes that permit sensitive detection and high-resolution characterization tumor angiogenesis could improve patient risk-benefit stratification. overarching objective experiments was develop dual modality ανβ3-targeted nanoparticle...
We present an integrated photoacoustic and ultrasonic three-dimensional (3-D) volumetric imaging system based on a two-dimensional (2-D) matrix array ultrasound probe. A wavelength-tunable dye laser pumped by Q-switched Nd:YAG serves as the light source modified commercial (iU22, Philips Healthcare) with 2-D transducer (X7-2, detects both pulse-echo signals. multichannel data acquisition acquires RF channel data. The enables rendering of co-registered 3-D images without mechanical scanning....
Photoacoustic tomography (PAT) is a molecular imaging technology. Unlike conventional reporter gene imaging, which usually based on fluorescence, photoacoustic relies only optical absorption. This work demonstrates several key merits of PAT using lacZ, one the most widely used genes in biology. We show that expression lacZ can be imaged by as deep 5.0 cm biological tissue, with resolutions ∼1.0 mm and ∼0.4 lateral axial directions, respectively. further demonstrate non-invasive, simultaneous...
Objectives The purpose of this study was to compare Superb Microvascular Imaging (SMI; Toshiba America Medical Systems, Tustin, CA) with conventional color flow Doppler (CFD) and power (PD) imaging in the liver distinguish between malignant benign neoplasms. Methods After Institutional Review Board approval (number 449984‐ED), patients undergoing routine pre–radiofrequency ablation planning ultrasound examinations for suspected hepatocellular carcinomas (HCCs) less than 2 cm diameter January...
Objectives To quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic elasticity systems and a magnetic resonance elastography (MRE) system in elastic viscoelastic phantoms. Methods Two phantoms, representing healthy through fibrotic liver, were measured with 5 ultrasound platforms, 3 liver tissue, 12 platforms. Measurements performed at sites, focal depths, appraisers. The SWS across was quantified as function system, site, depth, appraiser. A single...
Acoustic radiation force is applied to bubbles generated by laser-induced optical breakdown (LIOB) study viscoelastic properties of the surrounding medium. In this investigation, femtosecond laser pulses are focused in volume gelatin phantoms different concentrations form bubbles. A two-element confocal ultrasonic transducer generates acoustic on individual while monitoring their displacement within a Tone burst pushes varying duration have been outer element at 1.5 MHz. The inner receives...
Background Quantitative blood flow (QBF) measurements that use pulsed-wave US rely on difficult-to-meet conditions. Imaging biomarkers need to be quantitative and user machine independent. Surrogate markers (eg, resistive index) fail quantify actual volumetric flow. Standardization is possible, but relies collaboration between users, manufacturers, the U.S. Food Drug Administration. Purpose To evaluate a Biomarkers Alliance–supported, user- machine-independent method for quantitatively...
Real-time temperature monitoring with high spatial resolution (~1 mm) and sensitivity (1 °C or better) is needed for the safe deposition of heat energy in surrounding healthy tissue efficient destruction tumor abnormal cells during thermotherapy. A sensing technique using thermoacoustic photoacoustic measurements combined a clinical Philips ultrasound imaging system (iU22) has been explored this study. Using phantom, noninvasive method demonstrated to have temporal sensitivity. Because both...
Sentinel lymph node biopsy (SLNB) has emerged as an accurate, less invasive alternative to axillary dissection, and it rapidly become the standard of care for patients with clinically node-negative breast cancer. The sentinel (SLN) hypothesis states that pathological status axilla can be accurately predicted by determining first (i.e., sentinel) nodes drain from primary tumor. Physicians use radio-labeled sulfur colloid and/or methylene blue dye identify SLN, which is most likely contain...
To assess the effect of water intake on ultrasound tissue characteristics and hemodynamics adult livers.In February 2020, we prospectively performed shear wave elastography attenuation imaging (ATI) liver parenchyma, spectral Doppler sonography portal vein hepatic artery in 19 healthy volunteers (10 men 9 women, mean age 27 years, body mass index 24.65 kg/m2). We measured velocity (SWV, m/s), dispersion (SWD, m/s/kHz), coefficient (dB/cm/MHz), main (PVV, cm/s), peak systolic (PSV, end...
Photoacoustic (PA) and thermoacoustic (TA) effects are based on the generation of acoustic waves after tissues absorb electromagnetic energy. The amplitude signal is related to temperature absorbing target tissue. A combined photoacoustic imaging system built around a modified commercial ultrasound scanner was used obtain an image target's temperature, using reconstructed or images. To demonstrate these techniques, we monitor changes methylene blue solution buried at depth 1.5 cm in chicken...
Purpose To assess diagnostic performance of quantitative ultrasound (QUS) biomarkers in assessing hepatic steatosis. Methods We prospectively recruited 125 participants (mean age 54 years) who underwent liver QUS, magnetic resonance imaging (MRI), and laboratory tests within 30 days this IRB approved study. Based on MRI‐proton density fat fraction (MRI‐PDFF) MRE, we divided into normal liver, nonalcoholic fatty (NAFL) fibrosis (≥F1) groups. examined attenuation coefficient (AC), normalized...
We apply acoustic radiation force to bubbles generated by laser-induced optical breakdown (LIOB) study the mechanical response of surrounding medium. Optical occurs when sufficiently high threshold fluence is attained at focus femtosecond pulsed lasers, inducing plasma formation and bubble generation. LIOB are particular interest because they can be very precise locations parameters varied control size. In this investigation, laser pulses focused in volume gelatin phantoms different...