Johnson Chen

ORCID: 0000-0001-7794-9992
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Glioma Diagnosis and Treatment
  • Botulinum Toxin and Related Neurological Disorders
  • Inflammatory Bowel Disease
  • Cancer Treatment and Pharmacology
  • Ultrasound Imaging and Elastography
  • Liver Disease and Transplantation
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Cerebral Palsy and Movement Disorders
  • Liver Disease Diagnosis and Treatment
  • Diagnosis and treatment of tuberculosis
  • Brain Metastases and Treatment
  • Drug Transport and Resistance Mechanisms
  • Cancer Genomics and Diagnostics
  • Neuroscience and Music Perception
  • Stroke Rehabilitation and Recovery
  • Prostate Cancer Diagnosis and Treatment
  • Ultrasound and Hyperthermia Applications
  • Microscopic Colitis
  • Long-Term Effects of COVID-19
  • Peripheral Nerve Disorders
  • Sports injuries and prevention
  • Pancreatic and Hepatic Oncology Research
  • Action Observation and Synchronization
  • Abdominal Trauma and Injuries
  • Multisensory perception and integration

Cornell University
2013-2025

Weill Cornell Medicine
2017-2025

Vancouver General Hospital
2024

Northeast Ohio Medical University
2023

University of Atlanta
2023

University of South Carolina
2023

Thomas Jefferson University
2023

Texas Children's Hospital
2023

Baylor College of Medicine
2023

University of Alabama at Birmingham
2023

Objectives To discuss challenges in assessing hepatic steatosis using ultrasound hepatorenal index (HRI). Methods We retrospectively analyzed HRI and liver magnetic resonance imaging‐based proton density fat fraction (MRI‐PDFF) 134 adult participants (53 men 81 women, mean age 55 years). The diagnostic performance of for determining was tested by the area under receiver operating characteristic curve (AUROC) MRI‐PDFF as reference. Regression plots were employed to compare sampling sites...

10.1002/jum.16669 article EN Journal of Ultrasound in Medicine 2025-02-19

Background While Prostate Imaging Reporting and Data System (PI‐RADS) 4 5 lesions typically warrant prostate biopsy PI‐RADS 1 2 may be safely observed, 3 are equivocal. Purpose To construct cross‐validate a machine learning model based on radiomics features from T ‐weighted imaging (T WI) of to identify clinically significant cancer (csPCa), that is, pathological Grade Group ≥ 2. Study type Single‐center retrospective study. Population A total 240 patients were included (training cohort, n =...

10.1002/jmri.27692 article EN Journal of Magnetic Resonance Imaging 2021-05-10

Abstract BACKGROUND. The prognosis for patients with recurrent high‐grade gliomas is poor and treatment options are limited. Current chemotherapeutic regimens can improve clinical outcomes, but extend survival by only a few months. Temozolomide methylating agent that typically administered once daily. Because preclinical studies suggested twice‐daily dosing schedule might be more effective, the safety efficacy of temozolomide were studied in at their first, second, or third recurrence....

10.1002/cncr.23167 article EN Cancer 2008-02-01

Abstract Purpose: Drug resistance in brain tumors is partially mediated by the blood-brain barrier of which a key component P-glycoprotein, highly expressed cerebral capillaries. Tamoxifen nontoxic inhibitor P-glycoprotein. This trial assessed, primary and metastatic tumors, differential deposition paclitaxel whether tamoxifen could increase deposition. Experimental Design: Patients for surgical resection their or were prospectively randomized to prior alone (175 mg/m2/i.v.) 5 days followed...

10.1158/1078-0432.ccr-05-2356 article EN Clinical Cancer Research 2006-10-01

To quantitatively assess the correlation between corticomedullary strain ratio and cortical fibrosis in renal transplants.Using quasistatic ultrasound elasticity imaging, we prospectively assessed allografts of 33 patients who underwent transplant sonography biopsy. Based on Banff score criteria for fibrosis, were divided into 2 groups: group 1 (n = 19), with mild (<25%) fibrosis; 14), moderate (>26%) fibrosis. We used 2-dimensional speckle-tracking software to perform offline analysis...

10.7863/ultra.32.10.1769 article EN Journal of Ultrasound in Medicine 2013-09-24

To prospectively assess changes in spleen stiffness and splenoportal venous flow before after transjugular intrahepatic portosystemic shunt (TIPS) placement.We evaluated measured by the mean shear wave velocity with acoustic radiation force impulse imaging color Doppler sonography 12 patients (mean age ± SD, 42.6 11.0 years; range, 29-65 years) who underwent TIPS placement for portal hypertension gastroesophageal bleeding. The angle-corrected at main splenic veins were 1 day 3 to 9 days...

10.7863/jum.2013.32.2.221 article EN Journal of Ultrasound in Medicine 2013-02-01

Objectives The aim of the study was to assess feasibility ultrasound strain imaging in characterizing biceps brachii muscle chronic poststroke spasticity. Methods We prospectively analyzed data from bilateral muscles 8 healthy volunteers and 7 patients with Axial deformations overlying subcutaneous tissue were produced by external compression using a sandbag (1.0 kg) attached transducer. lengthening shortening manual passive elbow extension (from 90° 0°) flexion 0° 90°), respectively. used...

10.1002/jum.14558 article EN Journal of Ultrasound in Medicine 2018-02-05

Introduction: The serum-based endoscopic healing index (EHI) test identifies Crohn’s disease (CD) activity. Data are lacking on the relationship between EHI with other endpoints. We assessed and simplified Magnetic Resonance Index of Activity. Materials Methods: were prospectively collected patients CD either an or fecal calprotectin (FCAL) within 90 days magnetic resonance enterography (MRE). Diagnostic accuracy was using area under receiver operator characteristics. Proportions any,...

10.1097/mcg.0000000000001904 article EN Journal of Clinical Gastroenterology 2023-08-21

Purpose To assess diagnostic performance of quantitative ultrasound (QUS) biomarkers in assessing hepatic steatosis. Methods We prospectively recruited 125 participants (mean age 54 years) who underwent liver QUS, magnetic resonance imaging (MRI), and laboratory tests within 30 days this IRB approved study. Based on MRI‐proton density fat fraction (MRI‐PDFF) MRE, we divided into normal liver, nonalcoholic fatty (NAFL) fibrosis (≥F1) groups. examined attenuation coefficient (AC), normalized...

10.1002/jum.16185 article EN Journal of Ultrasound in Medicine 2023-02-06

Previous research suggests that COVID-19 infection may be associated with brain changes are similar to a decade of aging.1 It is unknown whether symptom duration influences structure. We compared participants symptoms for more than 2 months (long-COVID) (n=43) who recovered within (normal recovery) (n=56). assessed white matter diffusion tensor imaging, regional volumes using Freesurfer, and cognition the NIH Toolbox. Although effect age on MRI indices was readily detectable, we found no...

10.58530/2023/1902 article EN Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition 2024-08-14

The assessment of post-stroke muscle spasticity is challenging due to lack a gold standard. Modified Ashworth Scale (MAS), commonly used in evaluating neither quantitative or reliable. We have reported the use ultrasound strain imaging (USI) assess rigid biceps brachii (BBM) Parkinson's disease [1]. now extended application USI determining spastic BBM stroke survivors. performed 8 healthy volunteers and subjects with chronic upper limb. axial deformation was produced by external compression...

10.1109/ultsym.2017.8091938 article EN 2017 IEEE International Ultrasonics Symposium (IUS) 2017-09-01
Coming Soon ...