A5032726191- Physical Activity and Health
- Mobile Health and mHealth Applications
- Behavioral Health and Interventions
- Obesity, Physical Activity, Diet
- Cerebrovascular and Carotid Artery Diseases
- Hematopoietic Stem Cell Transplantation
- Advanced Clustering Algorithms Research
- Digital Mental Health Interventions
- Mental Health Research Topics
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Family and Disability Support Research
- Time Series Analysis and Forecasting
- Disability Education and Employment
- Chronic Disease Management Strategies
- Autism Spectrum Disorder Research
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Acute Lymphoblastic Leukemia research
- Blood Pressure and Hypertension Studies
- Gut microbiota and health
- Transplantation: Methods and Outcomes
- Mathematical Biology Tumor Growth
Columbia University
2016-2025
Columbia University Irving Medical Center
2012-2024
Feinstein Institute for Medical Research
2023
Parsons (United States)
2018
Stony Brook University
2018
Yale University
2018
NewYork–Presbyterian Hospital
2018
Cheung Kong Graduate School of Business
2017
University of North Carolina at Chapel Hill
2012
National Institute of Neurological Disorders and Stroke
2012
To determine whether unihemispheral hemodynamic failure is independently associated with cognitive impairment among participants in the National Institute of Neurological Disorders and Stroke-sponsored, multicenter, randomized clinical trial, Randomized Evaluation Carotid Occlusion Neurocognition (RECON).
Background: In the digital era when mHealth has emerged as an important venue for health care, application of computer science, such machine learning, proven to be a powerful tool care in detecting or predicting various medical conditions by providing improved accuracy over conventional statistical expert-based systems. Symptoms are often indicators abnormal changes body functioning due illness side effects from treatment. Real-time symptom report refers symptoms that patients experiencing...
<h3>Importance</h3> Patients with acute coronary syndrome (ACS) and elevated depressive symptoms are at increased risk for recurrent cardiovascular events mortality, worse quality of life, higher health care costs. These observational findings prompted multiple scientific panels to advise universal depression screening in survivors ACS prior evidence from randomized trials. <h3>Objective</h3> To determine whether systematically improves life compared usual care. <h3>Design, Setting,...
Background Previous cross-sectional studies have shown conflicting results regarding the effects of television viewing and occupational sitting on cardiovascular disease ( CVD ) risk factors. The purpose this study was to compare association both with events all-cause mortality in blacks. Methods Results Participants included 3592 individuals enrolled Jackson Heart Study, a community-based blacks residing Jackson, Mississippi. Television (<2, 2-4, >4 h/day) (never/seldom, sometimes,...
Introduction Cardiovascular disease (CVD) is the leading cause of mortality worldwide, though it may be prevented by increasing physical activity (PA). When behaviour change techniques (BCTs) are bundled together, they increase PA, which individual BCTs PA (and behavioural mechanism action (MoA) responsible for said increase) have not been studied. The aim this study to conduct a randomised factorial experiment determine four significantly engage proposed MoA—self-efficacy PA—in adults at...
Abstract BACKGROUND. The prognosis for patients with recurrent high‐grade gliomas is poor and treatment options are limited. Current chemotherapeutic regimens can improve clinical outcomes, but extend survival by only a few months. Temozolomide methylating agent that typically administered once daily. Because preclinical studies suggested twice‐daily dosing schedule might be more effective, the safety efficacy of temozolomide were studied in at their first, second, or third recurrence....
Summary Objectives: The understanding of how stress influences health behavior can provide insights into developing healthy lifestyle interventions. This is traditionally attained through observational studies that examine associations at a population level. nomothetic approach, however, fundamentally limited by the fact environment- person milieu constitutes exposure and experience vary substantially between individuals, modifiable elements these exposures experiences are...
Introduction: Various health-related data, subsequently called Person Generated Health Data (PGHD), is being collected by patients or presumably healthy individuals as well about them much they become available measurable properties in their work, home, and other environments. Despite that such data was originally just used for dedicated predefined purposes, more recently it regarded untapped resources call secondary use. Method: Since the use of PGHD still at its early evolving stage, we...
<b><i>Introduction:</i></b> Low cerebral blood flow can affect cognition in patients with high-grade asymptomatic internal carotid artery stenosis. Current clinical algorithms use stroke risk to determine which should undergo revascularization without considering cognitive decline. Although correlations between low-flow and impairment have been reported, it is not known whether a threshold exists below such correlation expresses itself. Such information would be...
The purpose of this study, which used mobile technologies to continuously collect data for 1 year, was examine the association psychological stress with objectively measured sedentary behavior in adults at both group (e.g., nomothetic approach) and individual idiographic level.Data were collected an observational study healthy (n = 79) residing New York City metro area who studied 365 days from 2014 2015. Sedentary via accelerometry. A smartphone-based electronic diary assess level...
8031 Background: Bortezomib is a proteasome inhibitor with anti-tumor activity in B cell malignancies. These effects, which may relate to NF-kappaB associated pathways, could sensitize tumor cells standard chemotherapy-based regimens and enhance efficacy. We report findings of phase I/II trial dose-escalated bortezomib + CHOP-rituximab DLBCL patients (accrual the MCL cohort this study remains ongoing). Methods: Patients previously untreated (n=40) received CHOP-21 rituximab (375 mg/m 2 each...
Gut microbiota may impact cognitive function and decline, though data are limited. This pilot study examines the associations between gut dysbiosis products, plasma lipopolysaccharide (LPS) soluble CD14 (sCD14), with decline immune molecule activation among 40 participants in longitudinal population-based Northern Manhattan Study.We selected stroke- dementia-free at baseline high levels of core components signaling pathways underlying metabolite-cognitive (IL-1, IL-17, TNF). Participants...
The determination of a Maximum Tolerated Dose (MTD) remains the main objective for most dose-finding oncology trials. Whilst many trials rely on clinicians to identify dose-limiting toxicities (DLTs), research has suggested that may under-report patient's adverse events. Current practice be vulnerable recommending intolerable doses patients further investigation in subsequent There is increasing interest self-assessing their own symptoms using Patient-reported Outcomes (PROs) However...
Owing to advances in sensor technologies on wearable devices, it is feasible measure physical activity of an individual continuously over a long period. These devices afford opportunities understand behaviors, which may then provide basis for tailored behavior interventions. The large volume data however poses challenges management and analysis. We propose novel quantile coarsening analysis (QCA) daily data, with goal reduce the while preserving key information. applied QCA longitudinal...
An increasing number of people use mobile devices to monitor their behavior, such as exercise, and record health status, psychological stress. However, these rarely provide ongoing support help users understand how behavior contributes changes in status. To address this challenge, we aim develop an interpretable policy for physical activity recommendations that reduce a user's perceived stress, over given time horizon. We formulate problem sequential decision-making solve it using new method...
<b><i>Introduction:</i></b> White matter hyperintensity volume (WMHV) and subclinical brain infarcts (SBI) are associated with impaired mobility, but less is known about the association of WMHV in specific regions. We hypothesized that anterior would be lower scores on Short Physical Performance Battery (SPPB), a well-validated mobility scale. <b><i>Methods:</i></b> The SPPB was measured median 5 years after enrollment into Northern Manhattan...
This paper presents a new model-based generalized functional clustering method for discrete longitudinal data, such as multivariate binomial and Poisson distributed data. For this purpose, we propose principal component analysis (MFPCA)-based procedure latent Gaussian process instead of the original data directly. The main contribution study is two-fold: modeling with developing algorithm based on MFPCA coupled process. Numerical experiments, including real simulation study, demonstrate...