A5007952891- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Diabetes Treatment and Management
- Intraocular Surgery and Lenses
- Ocular Disorders and Treatments
- RNA Interference and Gene Delivery
- Atrial Fibrillation Management and Outcomes
- Acoustic Wave Resonator Technologies
- Ocular Infections and Treatments
- Advanced MEMS and NEMS Technologies
- CRISPR and Genetic Engineering
- Mental Health via Writing
- Digital Marketing and Social Media
- Corneal Surgery and Treatments
- Ocular and Laser Science Research
- Systemic Lupus Erythematosus Research
- Adenosine and Purinergic Signaling
- Cardiovascular Function and Risk Factors
- Esophageal Cancer Research and Treatment
- Traumatic Ocular and Foreign Body Injuries
Seoul National University Hospital
2013-2025
Ajou University
2015-2024
NorthShore University HealthSystem
2024
Seoul National University
2010-2024
Abbott (United States)
2024
Sanofi (United Kingdom)
2023
Sungkyunkwan University
2017
Celltrion (South Korea)
2017
Sultan Ismail Specialist Hospital
2016
Hospital Sarikei
2016
Leber congenital amaurosis (LCA), one of the leading causes childhood-onset blindness, is caused by autosomal recessive mutations in several genes including RPE65. In this study, we performed CRISPR-Cas9-mediated therapeutic correction a disease-associated nonsense mutation Rpe65 rd12 mice, model human LCA. Subretinal injection adeno-associated virus carrying CRISPR-Cas9 and donor DNA resulted >1% homology-directed repair ~1.6% deletion pathogenic stop codon retinal pigment epithelial...
See also: Commentaire de travail J. H. Cheon et al., pp. 1046Endoscopy 2007; 39(12): 83-84DOI: 10.1055/s-0032-1308887
The Sewol ferry disaster severely shocked Korean society. objective of this study was to explore how the public mood in Korea changed following using Twitter data. Data were collected from daily posts 1 January 2011 31 December 2013 and March 2014 30 June natural language-processing text-mining technologies. We investigated emotional utterances reaction by analyzing appearance keywords, human-made disaster-related keywords suicide-related keywords. This elicited immediate reactions public,...
To investigate the effects of dyslipidemia and statin therapy on progression diabetic retinopathy macular edema in patients with type 2 diabetes.The medical records 110 diabetes (70 users 40 non-users) were retrospectively reviewed. The two outcome measures by or more steps early treatment study scale based optical coherence tomography. Serum lipid profiles analyzed from 6 months prior to diagnosis edema.Diabetic progressed 23% 18% non-users (p = 0.506), but was present 48% 0.008). Statins...
To investigate subfoveal choroidal thickness and subanalyze Haller Sattler layers in eyes with central serous chorioretinopathy (CSC), uninvolved fellow eyes, of healthy controls using enhanced depth imaging optical coherence tomography.Ocular findings clinical features 31 CSC, 24 30 were analyzed retrospectively from October, 2014 to March, 2015. Subfoveal was measured tomography, the thicknesses analyzed.Mean mean layer significantly greater CSC than (P = 0.043 P 0.036, respectively)...
Purpose: Lactic acid, the end product of glycolysis, has emerged as an immune-modulating metabolite in various diseases. In this study, we aimed to examine whether lactic acid contributes disease pathogenesis choroidal neovascularization (CNV) and investigate role macrophages CNV pathogenesis. Methods: was induced by laser photocoagulation C57BL/6J mice. concentration measured RPE-choroid region. Macrophage infiltration VEGF were quantified flow cytometry. VEGF-positive areas lesions...
Objective Suicide is a significant public health concern worldwide. Social media data have potential role in identifying high suicide risk individuals and also predicting rate at the population level. In this study, we report an advanced daily prediction model using social combined with economic/meteorological variables along observed lagged by 1 week. Methods The were drawn from weblog posts. We examined total of 10,035 keywords for prediction. made predictions national numbers 7 days...
There have been controversies in prognostic impact of mucinous histology on colorectal cancer, and its implication patients treated with adjuvant 5-fluorouracil, leucovorin, oxaliplatin (FOLFOX) is unclear. Stage II III cancer who underwent curative resection followed by FOLFOX were included. Patients grouped according to the content: >50%, adenocarcinoma (MAC); <50%, intermediated component (AIM); without any component, non-MAC (NMA). Clinicopathological features disease-free survival (DFS)...
To determine the subfoveal choroidal thickness and analyze Haller's layer, Sattler's large vessel diameter in eyes with active central serous chorioretinopathy (CSC) after resolution of CSC.Ocular clinical features 32 CSC were analyzed retrospectively from October 2014 to September 2015. Subfoveal thicknesses layer measured resolved states. The hyporeflective lumen (i.e., layer) was also measured.The mean thickness, significantly less (P < 0.001). However, did not change = 0.731). There no...
To investigate the effects of dipeptidyl peptidase-4 (DPP4) inhibitors on progression diabetic retinopathy (DR) in patients with Type 2 diabetes based DR severity scale.The medical records 82 enrolled from 2005 to 2015 were retrospectively reviewed. Fundus photographs graded using Early Treatment Diabetic Retinopathy Study methods. The associations between baseline risk factors and investigated.Seven 28 treated DPP4 26 54 other hypoglycemic agents showed retinopathy, defined as one or more...
The sodium-glucose cotransporter-2 inhibitors (SGLT2is) reduce the incidence of macrovascular complications diabetes, while their effect on diabetic retinopathy has not been clarified. We compared effects SGLT2is with those dipeptidyl peptidase-4 (DPP4is) risk and its progression in people type 2 diabetes. performed a retrospective cohort study among diabetes who started SGLT2i or DPP4i from 2014 to 2016 according Korean National Health Insurance Service database. Subjects initiated were...
Catalytic chemical vapour deposition (CCVD) is currently the most promising technique to produce carbon nanotubes (CNTs) on a specific site as well large-scale. Here, we review our recent experimental studies CNTs grown by CCVD. The yield structural characteristics of can strongly be affected choice catalyst support. In particular, CaCO3 found an excellent support material which actively contributes CNT growth. Our systematic study elastic measurements multi-walled CCVD indicates that...
// Sung Wook Park 1 , 2 Sora Im 3 Hyoung Oh Jun Kihwang Lee 4 Young-Jun 5 Jin Kim Woo Young-Hoon 6 and Jeong Hun 1,2,7 Department of Biomedical Sciences, Seoul National University College Medicine, Daehak-Ro, Jongno-Gu, Seoul, Republic Korea Fight Against Angiogenesis-Related Blindness Laboratory, Research Institute, Hospital, Life Sciences Concentration Gwangju Institute Science Technology Cheomdan-Gwagiro, Buk-Gu, Gwangju, Ophthalmology, Ajou School World Cup-Ro, Yeongtong-Gu, Suwon-Si,...
// Sung Wook Park 1,2 , Jin Hyoung Kim 1 Sang Min 3 Minho Moon 4 Kihwang Lee 5 Kyu Hyung 6,7 Woo and Jeong Hun 1,2,6 Fight against Angiogenesis-Related Blindness Laboratory, Biomedical Research Institute, Seoul National University Hospital, Jongno-gu, Seoul, Korea 2 Department of Sciences, College Medicine, University, Daehak-ro, Life Sciences Concentration GIST (Gwangju Institute Science Technology), Cheomdan-gwagiro, Buk-gu, Gwangju, Biochemistry, Konyang Seo-gu, Daejeon, Ophthalmology,...
Pigs are an attractive animal model to study the progression of cancer because their anatomical and physiological similarities human. However, use pig models for research has been limited by availability genetically engineered pigs which can recapitulate human progression. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us generate at a higher efficiency. In this study, specific systems were used target RUNX3, known tumour suppressor gene, that induce gastric in...
Pericytes (PCs) are crucial in maintaining the quiescence of endothelial cells (ECs) and integrity EC tight junctions. Especially diabetic retinopathy (DR), PC loss is one early pathologic changes capillaries retinas. Thus, preventing beneficial for attenuating vision impairment patients with DR. Although many studies have revealed mechanism retinas, little known about mechanisms that increase survival. We focused on effect β-adrenergic receptor agonists (β-agonists) In this study,...
Abstract We analysed the imaging findings of macular telangiectasia (MacTel) type 2 in Korea using spectral domain optical coherence tomography (SD-OCT) and investigated their relationship with visual acuity clinical stages. A retrospective multicentre cross-sectional study was conducted six tertiary hospitals included 129 patients. all SD-OCT images encompassing area. Hyporeflective cavities (77.7%) were most frequently detected abnormalities SD-OCT. Disruption external limiting membrane,...
In Brief Purpose: To evaluate the changes in blood pressure and intraocular (IOP) patients with without hypertension after intravitreal bevacizumab (Avastin) injection. Methods: This study examined 135 (74 nonhypertensive vs. 61 hypertensive) consecutive treated an injection of 1.25 mg for retinal vascular diseases prospectively over a 6-month period. All hypertensive were on medication, only controlled consultation cardiology specialists included. Intraocular measured before 30 minutes, 1...