A5012966752- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Palliative Care and End-of-Life Issues
- Digestive system and related health
- Eosinophilic Esophagitis
- Childhood Cancer Survivors' Quality of Life
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Geriatric Care and Nursing Homes
- Virus-based gene therapy research
- Family and Patient Care in Intensive Care Units
- Occupational and environmental lung diseases
- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Health and Risk Factors
- Cutaneous Melanoma Detection and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxoplasma gondii Research Studies
- Travel-related health issues
- PARP inhibition in cancer therapy
- Palliative and Oncologic Care
- Liver physiology and pathology
- Chronic Myeloid Leukemia Treatments
- Clostridium difficile and Clostridium perfringens research
Duke University
2024-2025
Duke Medical Center
2022
Drexel University
2020-2021
Memorial Sloan Kettering Cancer Center
2012-2020
Rapid City Regional Hospital
2018
Monash University
2005-2015
Frankston Hospital
2015
Institute of Immunology
2014
Office of Infectious Diseases
2014
Kettering University
2014
The bZIP transcription factor Nfil3 (also known as E4BP4) is required for the development of natural killer (NK) cells and type 1 innate lymphoid (ILC1s). We find that plays a critical role in other mucosal tissue-associated lymphocytes. Type 3 ILCs (ILC3s), including tissue inducer (LTi)–like cells, are severely diminished both numbers function Nfil3-deficient mice. Using mixed bone marrow chimeric mice, we demonstrate normal gut-associated ILC3s cell-intrinsic manner. Furthermore,...
T cell–derived interferon-γ can directly target intestinal stem cells to induce their apoptosis in a JAK/STAT-dependent manner (see the related Focus by Kretzschmar and Clevers ).
Abstract Innate Lymphoid Cells (ILCs) are immune cells typically found on mucosal surfaces and in secondary lymphoid organs where they regulate the response to pathogens. Despite their key role response, there still fundamental gaps our understanding of ILCs. Here we report a human ILC population present follicles tonsils lymph nodes termed follicular regulatory ILCs (ILC FR ) that knowledge has not been previously identified. have distinct phenotype transcriptional program when compared...
Individuals with Fanconi anemia (FA), a rare genetic bone marrow failure syndrome, have an increased risk of young‐onset head and neck squamous cell carcinomas (SCCs) esophageal SCC. The FA DNA repair pathway is activated upon damage induced by acetaldehyde, chief alcohol metabolite one the major carcinogens in humans. However, molecular basis acetaldehyde‐induced genomic instability SCCs esophagus remains elusive. Here, we report effects acetaldehyde on replication stress response...
Despite widespread use of antiretroviral therapy (ART), HIV remains a major public health issue. Even with effective ART many infected individuals still suffer from the constellation neurological symptoms now known as neuroHIV. These can be exacerbated by substance abuse, common comorbidity among HIV-infected individuals. The mechanism(s) which different types drugs impact neuroHIV unclear, but all abuse increase central nervous system (CNS) dopamine and elevated increases infection...
We have recently demonstrated that the function of T follicular helper (Tfh) cells from lymph nodes (LN) HIV-infected individuals is impaired. found these were unable to provide proper help germinal center (GC)-B cells, as observed by altered and inefficient anti-HIV antibody response premature death memory B cells. The underlying molecular mechanisms this dysfunction remain poorly defined. Herein, we used a unique transcriptional approach identify defects. consequently determined profiles...
IL-22+ Group 3 innate lymphoid cells (ILC3s) are critical for maintaining intestinal epithelial integrity. However, GVHD leads to elimination of ILC3s, ILC deficiency is associated with increased clinical GVHD, and IL-22 experimental GVHD-related mortality, pathology, loss stem (ISCs). We thus evaluated the mechanisms ILC3s in regeneration protection from GVHD. Utilizing an ex vivo organoid culture system, we found that co-culture murine small intestine (SI) crypts significantly growth...
Abstract Innate lymphoid cells (ILC) are a newly described population of immune implicated in the maintenance and function tissues as diverse liver, gut, lung lymph nodes. We have recently key role for ILC, their production IL-22, endogenous thymic regeneration: crucial process that allows renewal competence following depletion. Unlike other cells, ILC were extremely radio-resistant with little depletion after even lethal doses total body irradiation. Consistent these findings, considerable...