A5051137075- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- interferon and immune responses
- Gut microbiota and health
- Eosinophilic Esophagitis
- Chronic Kidney Disease and Diabetes
- CRISPR and Genetic Engineering
- Diabetes and associated disorders
- IL-33, ST2, and ILC Pathways
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
- Transgenic Plants and Applications
- Renal and related cancers
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Wound Healing and Treatments
- Clostridium difficile and Clostridium perfringens research
- Dermatology and Skin Diseases
- Renal Diseases and Glomerulopathies
- Neuropeptides and Animal Physiology
- Viral gastroenteritis research and epidemiology
Cornell University
2018-2025
Howard Hughes Medical Institute
2013-2025
Memorial Sloan Kettering Cancer Center
2013-2025
University of Chicago
2011-2020
Icahn School of Medicine at Mount Sinai
2010
Innate lymphoid cells (ILCs) contribute to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout the body. How ILCs maintain their presence in peripheral tissues thus far has been unclear. We found that nonlymphoid organs of adult mice, are tissue-resident were maintained expanded locally under physiologic conditions, upon systemic perturbation homeostasis during acute helminth infection. However, later time points after infection, from...
Abstract Regulatory T (T reg ) cells are a specialized CD4 + cell lineage with essential anti-inflammatory functions. Analysis of adaptations to non-lymphoid tissues that enable their immunosuppressive and tissue-supportive functions raises questions about the underlying mechanisms these whether they represent stable differentiation or reversible activation states. Here, we characterize distinct colonic effector transcriptional programs. Attenuated receptor (TCR) signaling acquisition...
Regulatory T (T reg) cells, a specialized subset of CD4+ are essential to prevent fatal autoimmunity. Expression the reg lineage-defining transcription factor Foxp3, and therefore their differentiation in thymus, is dependent upon cell receptor (TCR) interleukin-2 (IL-2) signaling. Here, we report that majority IL-2–producing cells thymus mature CD4 single-positive (CD4SP) thymocytes continuous IL-2 production sustained thymic generation control systemic immune activation. Furthermore,...
Abstract While regulatory T (T reg ) cells are traditionally viewed as professional suppressors of antigen presenting and effector in both autoimmunity cancer, recent findings distinct cell functions tissue maintenance suggest that their purview extends to a wider range is broader than previously assumed. To elucidate tumoral ‘connectivity’ diverse tumor-supporting accessory types, we explored immediate early changes single-cell transcriptomes upon punctual depletion experimental lung cancer...
The skin integrates diverse signals discerned by sensory neurons and immune cells to elicit adaptive responses a range of stresses. Considering interactions between nervous systems, we questioned whether regulatory T (Treg cells), cell subset that suppresses systemic local inflammation, can modulate activation peripheral neurons. Short-term ablation Treg increased neuronal noxious stimuli independently from immunosuppressive function. We find population is highly enriched for Penk...
Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage renal disease worldwide. Although the mechanisms underlying this important are poorly understood, glomerular podocyte clearly plays central role in pathogenesis. In current work, we demonstrate that homophilic adhesion molecule sidekick-1 (sdk-1) up-regulated podocytes FSGS both rodent models human kidney biopsy samples. Transgenic mice have podocyte-specific overexpression sdk-1 develop...
Abstract Regulatory T (Treg) cells represent a specialized CD4 + cell lineage with essential anti-inflammatory functions. Recent studies of the adaptations Treg to non-lymphoid tissues which enable their immunosuppressive and tissue supportive functions raise questions about underlying mechanisms these whether they stable differentiation or reversible activation states. Using novel genetic tools, we characterized transcriptional programs distinct colonic effector types. We found that...
Viruses, including retroviruses, can be passed from mothers to their progeny during birth and breastfeeding. It is assumed that newborns may develop immune tolerance milk-transmitted pathogens similarly food antigens. I/LnJ mice are uniquely resistant retroviruses acquired as or adults they produce virus-neutralizing antibodies (Abs). A loss-of-function allele of H2-Ob (Ob), originally mapped within the virus infectivity controller 1 (vic1) locus, responsible for production antiretrovirus...
Abstract Adult stem cells reside in various tissues to govern homeostasis and repair damage. During wound healing, these must be mobilized enter the center of injury where they are exposed many inflammatory immune infiltrating wounded tissue. While indispensable for preventing infections clearing dead cells, can also create a harsh environment which could potentially damage prevent their self-renewal differentiation. Here, using model cutaneous healing hair follicle (HFSCs) wound, we show...