A5078389415- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Gut microbiota and health
- Diabetes and associated disorders
- Career Development and Diversity
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Pancreatitis Pathology and Treatment
- Interdisciplinary Research and Collaboration
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Drug Transport and Resistance Mechanisms
- Tryptophan and brain disorders
- Respiratory Support and Mechanisms
- Liver Diseases and Immunity
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health and Medical Research Impacts
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Organ Transplantation Techniques and Outcomes
- Cholesterol and Lipid Metabolism
- Cancer, Hypoxia, and Metabolism
- Sepsis Diagnosis and Treatment
CeMM Research Center for Molecular Medicine
2022-2025
Austrian Academy of Sciences
2022-2025
Howard Hughes Medical Institute
2013-2022
Memorial Sloan Kettering Cancer Center
2013-2022
Cornell University
2018
Pulmonary fibrosis is an incurable disease that manifests with advanced age. Yet, how hematopoietic aging influences immune responses and progression remains unclear. Using heterochronic bone marrow transplant mouse models, we found aged exacerbates lung irrespective of tissue Upon injury, there was increased accumulation monocyte-derived alveolar macrophages (Mo-AMs) driven by cell-intrinsic aging. These Mo-AMs exhibited enhanced profibrotic profile stalled maturation into a homeostatic,...
Significance Anorexia or decreased appetite is a common feature of infection. The effects acute nutritional stress on effector T cells, which are required for pathogen-specific responses and protective immunological memory, not fully understood. We show that reduced food intake during infection decreases the numbers cells in manner dependent Farnesoid X Receptor (FXR). FXR was previously implicated controlling hepatic to fasting. Our findings suggest functions promote coherent physiological...
T cells increase cholesterol biosynthesis upon activation to generate substrates for cellular growth and proliferation. The ubiquitously expressed liver X receptor β (LXRβ) encoded by the Nr1h2 gene is a critical regulator of homeostasis in mammalian cells; however, its cell-intrinsic role cell biology remains poorly understood. We report that ablation LXRβ leads spontaneous lymphocytopenia. Unexpectedly, analysis mixed bone marrow chimeric mice revealed cell-autonomous survival defect...
Dysregulation of the inflammatory response against infection contributes to mortality in sepsis. Inflammation provides critical host defense, but it can cause tissue damage, multiple organ failure, and death. Because nuclear transcription factor peroxisome proliferator-activated receptor γ (PPARγ) exhibits therapeutic potential, we characterized role PPARγ We analyzed severity clinical signs, survival rates, cytokine production, leukocyte influx, bacterial clearance a cecal ligation puncture...
This year at JEM, we are highlighting women in science by sharing their stories and amplifying voices. In this Viewpoint, hear from a cross section of women, across multiple research fields, discussing the process setting up lab as an independent researcher.