A5057892710- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Gut microbiota and health
- Digestive system and related health
- Immune responses and vaccinations
- Probiotics and Fermented Foods
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Extracellular vesicles in disease
CeMM Research Center for Molecular Medicine
2025
University of Vienna
2025
Austrian Academy of Sciences
2025
Max Perutz Labs
2025
Vienna Biocenter
2025
Pulmonary fibrosis is an incurable disease that manifests with advanced age. Yet, how hematopoietic aging influences immune responses and progression remains unclear. Using heterochronic bone marrow transplant mouse models, we found aged exacerbates lung irrespective of tissue Upon injury, there was increased accumulation monocyte-derived alveolar macrophages (Mo-AMs) driven by cell-intrinsic aging. These Mo-AMs exhibited enhanced profibrotic profile stalled maturation into a homeostatic,...
Microbial exposure at barrier interfaces drives development and balance of the immune system, but consequences local infections for systemic immunity secondary inflammation are unclear. Here, we show that skin to bacterium Staphylococcus aureus persistently shapes system mice with specific impact on progenitor mature bone marrow neutrophil eosinophil populations. The infection-imposed changes in eosinophils were long-lasting associated functional as well imprinted epigenetic metabolic...
Acute, inflammatory processes contribute to the fact that conventionally pathogenic and microorganisms colonize mucous membranes of small intestine form biofilms, can become a source bacterial toxin, which, when epithelial layer breaks, penetrates lymphatic blood systems, contributing formation sepsis. The barrier function epithelium is critical in development bowel diseases, while normal functioning requires constant balance between reactivity tolerance intestinal lumen. Increased...