A5054827801- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
Memorial Sloan Kettering Cancer Center
2022-2024
Spatially resolved gene expression profiling provides insight into tissue organization and cell-cell crosstalk; however, sequencing-based spatial transcriptomics (ST) lacks single-cell resolution. Current ST analysis methods require RNA sequencing data as a reference for rigorous interpretation of cell states, mostly do not use associated histology images are capable inferring shared neighborhoods across multiple tissues. Here we present Starfysh, computational toolbox using deep generative...
Abstract While regulatory T (T reg ) cells are traditionally viewed as professional suppressors of antigen presenting and effector in both autoimmunity cancer, recent findings distinct cell functions tissue maintenance suggest that their purview extends to a wider range is broader than previously assumed. To elucidate tumoral ‘connectivity’ diverse tumor-supporting accessory types, we explored immediate early changes single-cell transcriptomes upon punctual depletion experimental lung cancer...
Abstract Spatially-resolved gene expression profiling provides valuable insight into tissue organization and cell-cell crosstalk; however, spatial transcriptomics (ST) lacks single-cell resolution. Current ST analysis methods require RNA sequencing data as a reference for rigorous interpretation of cell states do not utilize associated histology images. Significant sample variation further complicates the integration datasets, which is essential identifying commonalities across tissues or...