A5086765168- IL-33, ST2, and ILC Pathways
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Eosinophilic Esophagitis
- Food Allergy and Anaphylaxis Research
- Forensic and Genetic Research
- RNA Research and Splicing
Hospital for Special Surgery
2020-2024
Cornell University
2020-2024
Weill Cornell Medicine
2022-2024
New York Proton Center
2024
Memorial Sloan Kettering Cancer Center
2022-2024
Abstract Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital for the preservation of organismal health. Within thymus, medullary thymic epithelial cells (mTECs) expressing autoimmune regulator (AIRE) have a critical role in self-tolerance through deletion autoreactive T promotion regulatory (T reg ) cell development 1–4 . weeks birth, separate wave differentiation occurs periphery upon exposure derived from diet commensal microbiota 5–8 , yet types...
Abstract The intestinal immune system must establish tolerance to food antigens prevent onset of allergic and inflammatory diseases. Peripherally generated regulatory T (pTreg) cells play an essential role in suppressing responses allergens; however, the antigen-presenting cell (APC) that instructs food-specific pTreg is not known. Here, we show antigen presentation TGF-β activation by a subset RORγt + (APC), Thetis IV (TC IV), required for food-induced differentiation oral tolerance. By...
Macrophages are key drivers of inflammation and tissue damage in autoimmune diseases including rheumatoid arthritis. The rate-limiting step for transcription more than 70% inducible genes macrophages is RNA polymerase II (Pol II) promoter-proximal pause release; however, the specific role Pol early elongation control inflammation, whether it can be modulated therapeutically, unknown. Genetic ablation a pause-stabilizing negative factor (NELF) did not affect baseline occupancy but enhanced...
Macrophages (MФ) and microglia (MG) are critical in the pathogenesis of multiple sclerosis (MS) its mouse model, experimental autoimmune encephalomyelitis (EAE). Glucocorticoids (GCs) interferon β (IFN-β) frontline treatments for MS, disrupting each pathway mice aggravates EAE. Glucocorticoid receptor–interacting protein 1 (GRIP1) facilitates both GR type I IFN transcriptional actions; hence, we evaluated role GRIP1 neuroinflammation. Surprisingly, myeloid cell–specific loss dramatically...
Abstract Establishing and maintaining tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing A uto I mmune Re gulator, Aire, play a critical role in self-tolerance through deletion autoreactive T promotion regulatory (Treg) cell development. weeks birth, separate wave Treg differentiation occurs periphery, upon exposure dietary commensal microbiota derived antigens, yet types...