A5052714076- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Advanced Biosensing Techniques and Applications
- 3D Printing in Biomedical Research
- Soft tissue tumor case studies
- RNA Research and Splicing
- Rheumatoid Arthritis Research and Therapies
- Bone Tumor Diagnosis and Treatments
- Viral-associated cancers and disorders
- Cytokine Signaling Pathways and Interactions
- Pancreatitis Pathology and Treatment
- Medical Imaging Techniques and Applications
- Orthopaedic implants and arthroplasty
- Nanofabrication and Lithography Techniques
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- Systemic Lupus Erythematosus Research
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Virus-based gene therapy research
- Histiocytic Disorders and Treatments
- Orthopedic Infections and Treatments
- Lymphoma Diagnosis and Treatment
Hospital for Special Surgery
2018-2025
Washington University in St. Louis
2024
Northeastern University
2021-2024
Arizona State University
2008-2021
Center for Theoretical Biological Physics
2021
Memorial Sloan Kettering Cancer Center
2017-2020
Hofstra University
2020
Northwell Health
2018-2020
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2019-2020
Rutgers, The State University of New Jersey
2015
Single-cell RNA sequencing studies have revealed the heterogeneity of cell states present in rheumatoid arthritis (RA) synovium. However, it remains unclear how these types interact with one another situ and synovial microenvironments shape observed states. Here, we use spatial transcriptomics (ST) to define stable across eight tissue samples from six RA patients characterize cellular composition ectopic lymphoid structures (ELS). To identify disease-relevant communities, developed...
The identification of implant wear particles and non-implant related the characterization inflammatory responses in periprosthetic neo-synovial membrane, bone, synovial-like interface membrane (SLIM) play an important role for evaluation clinical outcome, correlation with radiological retrieval studies, understanding biological pathways contributing to failures joint arthroplasty. purpose this study is present a comprehensive histological particle algorithm (HPA) as practical guide at...
Epithelial-mesenchymal transition (EMT) is well established as playing a crucial role in cancer progression and being potential therapeutic target. To elucidate the gene regulation that drives decision making of EMT, many previous studies have been conducted to model EMT regulatory circuits (GRCs) using interactions from literature. While this approach can depict generic interactions, it falls short capturing context-specific features. Here, we explore effectiveness combined bioinformatics...
Aims Histones are essential components of chromatin, and mutations in histones lead to alterations methylation acetylation, which play an important role tumorigenesis. Most the chondroblastomas harbour H3K36M mutation. With availability a mutation‐specific antibody, we sought assess sensitivity this antibody histone series chondroblastoma cases. Methods results Immunohistochemical staining with antibodies against H3K36M, trimethylated (H3K27me3 H3K36me3) osteoblastic marker ( SATB 2) was...
Abstract Protein arginylation is an essential posttranslational modification (PTM) catalyzed by arginyl-tRNA-protein transferase 1 (ATE1) in mammalian systems. Arginylation features a post-translational conjugation of arginyl to protein, making it extremely challenging differentiate from translational arginine residues with the same mass protein sequence. Here we present general activity-based profiling (ABAP) platform for unbiased discovery substrates and their precise sites. This method...
Follicular dendritic cell sarcoma (FDCS) is a rare and unusual cancer that arises from sustentacular cells of the lymph node present antigen to B cells, rather than lymphocytes themselves. While surgery for primary disease still paramount in management, unresectable, recurrent metastatic tumours, FDCS frequently treated with anthracycline-based lymphoma chemotherapy regimens. In recent years, it clear Programmed Cell Death 1 (PD1)-directed immune checkpoint inhibitors (ICIs) are active...
Abstract Epithelial–mesenchymal transition (EMT) is an important biological process through which epithelial cells undergo phenotypic transitions to mesenchymal by losing cell–cell adhesion and gaining migratory properties that use in embryogenesis, wound healing, cancer metastasis. An research topic identify the underlying gene regulatory networks (GRNs) governing decision making of EMT develop predictive models based on GRNs. The advent recent genomic technology, such as single‐cell RNA...
A 72-year-old female presented with dyspepsia for 2 years and an incidental mass in the head of pancreas on abdominal computed tomography (CT) scan. Patient had multiple negative endoscopic ultrasound guided biopsies. She was followed up 3 serial imaging until CT scan showed increase size pancreatic mass. Physical examination unremarkable. Laboratory tests including tumor markers were normal. Given enlarging its impingement portal vein, consensus to proceed surgery. Histology revealed a 3.5...
We describe a case of 44-year-old woman with locally advanced aggressive angiomyxoma novel translocation high-mobility group AT-hook 2–yes-associated protein 1 ( HMGA2-YAP1 ) fusion, implying t(11;12)(q22.1;q14.3) translocation. She was started on gonadotropin-releasing hormone agonist injection and an aromatase inhibitor for persistent disease, which responded to treatment; she subsequently treated radiation before more definitive operation conducted. This report indicates that HGMA2-YAP1–...
Objective We sought to develop computer vision methods quantify aggregates of cells in synovial tissue and compare these with clinical gene expression parameters. Methods assembled a pipeline five features encompassing cell density compared pathologist scores, disease classification, autoantibody status, RNA cohort 156 patients rheumatoid arthritis (RA) 149 osteoarthritis (OA). Results All were associated scores lymphocytic inflammation ( P < 0.0001). Three that related the per unit...
Infantile fibrosarcoma usually presents as a rapidly growing mass on the extremities or trunk. We describe spontaneous regression in 5-month-old female infant with biopsy proven, molecularly confirmed, right leg infantile currently at 26 months of age no signs local recurrence. Previously reported cases are reviewed, suggesting benign clinical course some cases. Although evidence for is anecdotal this rare tumor type, physicians should weigh risks and benefits surgery chemotherapy against...
Macrophages are key drivers of inflammation and tissue damage in autoimmune diseases including rheumatoid arthritis. The rate-limiting step for transcription more than 70% inducible genes macrophages is RNA polymerase II (Pol II) promoter-proximal pause release; however, the specific role Pol early elongation control inflammation, whether it can be modulated therapeutically, unknown. Genetic ablation a pause-stabilizing negative factor (NELF) did not affect baseline occupancy but enhanced...
Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation of poorly differentiated cells, with a heterogenous mutational landscape. Mutations in IDH1 and IDH2 are found 20% the AML cases. Although much effort has been made to identify genes associated leukemogenesis, regulatory mechanism state transition still not fully understood. To alleviate this issue, here we develop new computational approach that integrates genomic data from diverse sources, including gene expression...
e23574 Background: FDCS and HS are rare tumors arising from sustentacular cells of the lymph node, rather than lymphocytes. Surgical resection is often employed in case localized disease, but for unresectable anthracycline-based therapy commonly used. PD-L1 staining reportedly positive 50-80% FDCS. As a result, we treated 3 patients (pts) with ICI ipilimumab nivolumab (Ipi/Nivo), demonstrated activity these agents cancers. Methods: Two pts one pt, all B symptoms at start treatment, received...
Soft tissue masses of the fingers have a broad differential, including both benign and malignant etiologies. Of these, lipomatous tumours finger are exceedingly rare, with subset neurolipomas, rarer still. Often referred to as lipofibromatous hamartoma (LFH), or lipomatosis nerve, among more than ten other descriptive terms, these generally associated macrodactyly frequently involve branches median nerve upper extremity, leading spectrum neurologic sequelae. These represent diagnostic...